Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

“…With single cell RNA-seq analysis, we have determined that NTS was also produced specifically by the lymphatic endothelial cells (LECs) as an anti-thermogenic peptide in the brown adipose tissue (23) and a pro-lipid absorption peptide regulating the development of atherosclerosis in the intestine (24)(25)(26). Ntsr2, but not Ntsr1, is widely expressed in brown adipocytes, beige adipocytes and white adipocytes (27).…”

Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice

“…Our previous studies have shown that LECs secrete NTS in various tissues, including adipose tissues, skin, and liver. 4 , 5 To investigate the effects of LEC-derived NTS on atherosclerosis development, we developed an inducible Nts knockout mouse model (C57BL6/J) restricted to LECs ( Prox1-cre/ERT2::Nts flox/flox , referred as Nts −/− mice hereafter), with the same design and tamoxifen treatment strategy as previously described. 5 The experimental details were described in https://data.mendeley.com/datasets/c5yrdg5vtx/1 .…”

“… 4 , 5 To investigate the effects of LEC-derived NTS on atherosclerosis development, we developed an inducible Nts knockout mouse model (C57BL6/J) restricted to LECs ( Prox1-cre/ERT2::Nts flox/flox , referred as Nts −/− mice hereafter), with the same design and tamoxifen treatment strategy as previously described. 5 The experimental details were described in https://data.mendeley.com/datasets/c5yrdg5vtx/1 . All the experiments were approved by the Institutional Animal Care and Use Committee of the School of Life Science at Fudan University (IDM2021006d).…”