2021
DOI: 10.3390/md19070397
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Metabolomic Characterization of a cf. Neolyngbya Cyanobacterium from the South China Sea Reveals Wenchangamide A, a Lipopeptide with In Vitro Apoptotic Potential in Colon Cancer Cells

Abstract: Metabolomics can be used to study complex mixtures of natural products, or secondary metabolites, for many different purposes. One productive application of metabolomics that has emerged in recent years is the guiding direction for isolating molecules with structural novelty through analysis of untargeted LC-MS/MS data. The metabolomics-driven investigation and bioassay-guided fractionation of a biomass assemblage from the South China Sea dominated by a marine filamentous cyanobacteria, cf. Neolyngbya sp., has… Show more

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Cited by 9 publications
(3 citation statements)
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“…ferment that displayed in vitro apoptotic potential towards colon cancer cells. 109 The antiparasitic lipopeptide lead, hoshinoamide C 223 , was identified from Caldora penicillata . To determine the absolute configuration of the unusual amino acid moiety, 8-amino-4-methyloctanoic acid, found in 223 , two possible diastereomers of hoshinoamide C were synthesised.…”
Section: Marine Microorganisms and Phytoplanktonmentioning
confidence: 99%
“…ferment that displayed in vitro apoptotic potential towards colon cancer cells. 109 The antiparasitic lipopeptide lead, hoshinoamide C 223 , was identified from Caldora penicillata . To determine the absolute configuration of the unusual amino acid moiety, 8-amino-4-methyloctanoic acid, found in 223 , two possible diastereomers of hoshinoamide C were synthesised.…”
Section: Marine Microorganisms and Phytoplanktonmentioning
confidence: 99%
“…Furthermore, multivariate analysis and machine learning tools have recently been implemented in GNPS to compare molecular profiles collected from different groups/types of samples [150]. Beyond its extensive application in natural product discovery, clinical and environmental studies, applications in skin studies included the identification of molecular signatures associated with individual lifestyles and further linked them to the built environment, investigating the impact of personal care products on the skin metabolomics and microbiome dynamics or even monitoring drugs and their metabolites directly on human skin [69,[151][152][153][154][155][156][157][158]. Molecular networking has also proven to efficiently assign the origin of molecules detected on human skin (skin cells, microbes, environment, and lifestyles) [147,156,159].…”
Section: Perspectives For Skin Microbiome Metabolomics Analysismentioning
confidence: 99%
“…This effect was related to cell cycle arrest at the G2/M phase and the induction of apoptosis. However, the same cell cycle arrest or apoptosis pattern was not observed in normal human dermal fibroblasts (NHDF), suggesting a specificity to cancer cells [ 14 ]. Wenchangamide A has a structural resemblance to minnamide A ( Figure 15 b), a cyanobacterial natural product of Okeania hirsute .…”
Section: Marine Cyanobacterial Metabolites With Cytotoxic Antiprolife...mentioning
confidence: 99%