Metabolomic Mining of the Botanical Dietary Supplement Wild Yam (Dioscorea villosa L.)

Dong, SH; Cai, Guojing; Napolitano, JG; Nikolić, D; Lankin, DC; McAlpine, JB; Breemen, Richard B. van; Soejarto, DD; Qiu, Faxuan; Simmler, Charlotte; Pauli, GF; Chen, SN

doi:10.1055/s-0033-1348620

Cited by 26 publications

(1 citation statement)

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“…[3] However, further research revealed a number of pharmacological activities of this alkaloid, such as anti-inflammatory, gastrointestinal, hypoglycemic and cholesterol-lowering effects etc. [4][5][6] The antiviral activities of isoquinolines are also not uncommon in the literature. [7][8][9] For example, the antiviral activities of isoquinoline drugs against rhinoviruses were described [10] way back in 1970 whereas potential of selected isoquinoline alkaloids against main protease (M pro ) of SARS-CoV-2 was explored recently.…”

Section: Introductionmentioning

confidence: 99%

In Silico Evaluation of 1‐Aminoisoquinoline Derivatives against Dengue Virus: Greener Access via a Sonochemical Method

Prasada Rao,

Bhuvan Tej,

Raju

et al. 2024

ChemistrySelect

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The reported antiviral properties of isoquinolines including that of berberine against dengue virus prompted us exploring a series of 1‐aminoisoquinoline derivatives against RdRp and MTase domain of NS5 protein of dengue virus (DENV) in silico. While MTase is known to assists in viral RNA capping, the RdRp plays a key role in the virus replication. The docking of 1‐aminoisoquinolines into the DENV NS5 protein RdRp domain (PDB: 5I3Q) in silico revealed good interactions of one molecule involving the H‐bond interactions through its NO2 group with GLN802, LEU511 and HIS512 residues. Notably, the docking of these compounds into the DENV NS5 protein DENV3 MTase (PDB: 5EHG) in silico also indicated same molecule as the most encouraging potential entity as the molecule participated in three H‐bond interactions through its NO2 group with GLY86, TRP87, SER56 residues. The synthesis of 1‐aminoisoquinolines was undertaken under sonochemical conditions via the reaction of 1‐chloroisoquinoline with appropriate amines in the presence of Cs2CO3 in DMSO. Among them, three encouraging compounds did not cause any significant cytotoxicity towards Vero cells but showed good to moderate inhibition of DENV2.

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Section: Introductionmentioning

confidence: 99%

In Silico Evaluation of 1‐Aminoisoquinoline Derivatives against Dengue Virus: Greener Access via a Sonochemical Method

Prasada Rao,

Bhuvan Tej,

Raju

et al. 2024

ChemistrySelect

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Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods

Visioli¹,

Poli²

2019

Handbook of Experimental Pharmacology

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Nutritional interventions are effective and – in theory – easy to implement primary and secondary prevention strategies that reduce several risk factors of atherosclerosis and cardiovascular disease (CVD). Yet, because of (a) the severe impact of CVD in terms of mortality, morbidity, quality of life, and economy, (b) the proved role of LDL plasma concentrations as the most critical risk factor, and (c) the obstacles found both in terms of biological effects and compliance of the patient by an exclusively dietary intervention, food supplements or nutraceuticals are now valuable resources for physicians. As regards cholesterol control, several preparations are available in the market, and we will critically review them in this chapter.

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Nutraceuticals and Lipid Management

Sachinidis

Nikolić

Stoian

et al. 2020

Contemporary Cardiology

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Metabolomic Mining of the Botanical Dietary Supplement Wild Yam (Dioscorea villosa L.)

Cited by 26 publications

References 0 publications

In Silico Evaluation of 1‐Aminoisoquinoline Derivatives against Dengue Virus: Greener Access via a Sonochemical Method

In Silico Evaluation of 1‐Aminoisoquinoline Derivatives against Dengue Virus: Greener Access via a Sonochemical Method

Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods

Nutraceuticals and Lipid Management

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