Metabolomic Study of a Diagnostic Model for the Metabolites of Stool Fat

Abstract

The metabolomic assay of stool fatty acid revealed mainly lysoPEs and lithocholic acid. The size of the fatty acid was correlated with higher concentrations of lysoPEs and lithocholic acid in stool-fat-test-positive specimens and related to loose stool even after three years of follow-up period.

Phenolamide extract of apricot bee pollen alleviates glucolipid metabolic disorders and modulates the gut microbiota and metabolites in high-fat diet-induced obese mice

“…67,68 Some studies have shown that the main fat in human feces is from some metabolites such as lysoPE. 69 LysoPE, a product of PE hydrolysis, can induce hepatic lipid accumulation and affect hepatic lipid metabolism. 70 PAE intervention upregulated the abundance of lysoPE in HFD-fed mice, indicating that PAE may regulate lipid metabolism by promoting lipid excretion.…”

“…67,68 Some studies have shown that the main fat in human feces is from some metabolites such as lysoPE. 69 LysoPE, a product of PE hydrolysis, can induce hepatic lipid…”

Rumen-protected glucose supplementation alters fecal microbiota and its metabolic profiles in early lactation dairy cows

“…LysoPE(16:1(9Z)/0:0) is a kind of lysophosphatidylethanolamine (LysoPE) that belongs to glycerophospholipids, resulting from the partial hydrolysis of PE. Metabolites such as LysoPE were related to the amount of fatty acid in feces (Lee et al, 2013). As stated before, Nuli explored the mechanisms underlying the potential characteristic metabolite changes during different glycemic stages and demonstrated that significantly changed metabolites LysoPC and PE between the normal group and the impaired glucose regulation patients were involved in glycerophospholipid metabolism (Nuli et al, 2019).…”