Metabolomics analysis reveals the protective effect of quercetin‐3‐O‐galactoside (Hyperoside) on liver injury in mice induced by acetaminophen

Hu, Cheng; Chen, Ying; Cao, Yiyuan; Jia, Yanming; Zhang, Jiaqi

doi:10.1111/jfbc.13420

Cited by 20 publications

(11 citation statements)

References 31 publications

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“…APAP is biotransformed to NAPQI, which conjugates with GSH and depletes it, then NAPQI binds to various enzymes, causing mitochondrial dysfunction and oxidative stress [ 23 ]. In this work, the presence of several flavonoids has been found, including quercetin, and luteolin, which prevent GSH depletion according to several studies [ 69 , 70 , 71 ].…”

Section: Discussionmentioning

confidence: 75%

Nutritional and Bioactive Characterization of Sicana odorifera Naudim Vell. Seeds By-Products and Its Potential Hepatoprotective Properties in Swiss Albino Mice

Caballero

Mereles

Burgos-Edwards

et al. 2021

Biology

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The “Kurugua” (Sicana odorifera) is a native fruit that demonstrates attractive nutritional, coloring, flavoring, and antioxidant properties. The main by-products from the processing and consumption of kurugua fruit are epicarp and seeds. In this work, the properties of the seeds of S. odorifera were evaluated. The nutritional composition of the fruit seeds was determined through AOAC official methods and UHPLC-ESI-MS/MS profiling. The antioxidant activities were determined using in vitro methods, and the acute toxicity and hepatoprotective properties were investigated in Swiss albino mice. Quercetin derivatives and cucurbitacins were the main phytochemicals in the seeds’ methanolic extract and demonstrated some biological activities. GC-MS analysis revealed the essential fatty acids linolenic and linoleic as the main compounds present in seeds oil. The methanolic extract significantly reduced the serum levels of glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) in mice with induced hepatotoxicity (GPT p < 0.05; GOT p < 0.001) at the minor concentration tested (100 mg/kg EMSo). The results suggest that the S. odorifera seeds as by-products show potential use as a source of phytochemicals and in the production of oils with application in food supplements and nutraceuticals. Their integral use could contribute to waste reduction from kurugua fruits processing within the food safety and environmental sustainability framework.

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Section: Discussionmentioning

confidence: 75%

Nutritional and Bioactive Characterization of Sicana odorifera Naudim Vell. Seeds By-Products and Its Potential Hepatoprotective Properties in Swiss Albino Mice

Caballero

Mereles

Burgos-Edwards

et al. 2021

Biology

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“…Metabolite enrichment analysis was performed using the web application ChemRich (chemrich.fiehnlab.ucdavis.edu). Metabolic pathway analysis was performed using MetaboAnalyst (http://www.metaboanalyst.ca) (Hu et al ., 2020).…”

Section: Methodsmentioning

confidence: 99%

Metabolites of the Soy Sauce Koji Making with Aspergillus niger and Aspergillus oryzae

Liu

et al. 2021

Int J of Food Sci Tech

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Koji making comprises multi-microbial interactions and is an important part of soy sauce production. The aim of this study was to determine interactions and investigate metabolites in koji by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/ TOF-MS). Differential metabolites between groups of single strain (Aspergillus oryzae) and mixed strains (Aspergillus niger and A. oryzae) koji making were screened and identified using an untargeted metabolomics approach to evaluate microbial interaction. A. oryzae was the dominant strain in koji mixed fermentation. Growth of both fungal species occurred rapidly during the initial 24 h of fermentation and then stabilised. Inoculation of A. niger led to changes in the contents of dipeptides, flavonoids, unsaturated fatty acids, carotenoids, phenols and indoles in koji. These differences could be attributed to glycerophospholipid and glycerolipid m4etabolism, as well as to pantothenate and CoA biosynthesis of A. niger.

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“…Although NAC has been considered a standard therapeutic agent for relieving acetaminophen poisoning, there still exist certain limitations for its use due to the possibility of inducing hepatic steatosis and systemic inflammation [ 47 ]. Several studies have investigated the efficacy of Hyp in reducing hepatotoxicity in mice and liver cells suffering from drug-induced liver injury [ 48 , 49 , 50 , 51 ].…”

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Jang

2022

Antioxidants

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Hyperoside (Hyp), also known as quercetin-3-O-galactoside or 3-O-β-D-galactopyranosyl, is a well-known flavonol glycoside that is abundant in various fruits, vegetables, and medicinal plants. Hyp has been suggested to exhibit a wide range of biological actions, including cardiovascular, renal, neuroprotective, antifungal, antifibrotic, and anticancer effects. Accumulating evidence supports the pharmacological activities of Hyp in improving liver pathophysiology. Hence, the present literature review aims to summarize preclinical data suggesting the beneficial effects and underlying mechanisms of Hyp. In addition, our study focuses on hepatic antioxidant defense signaling to assess the underlying mechanisms of the biological actions of Hyp that are closely associated with liver diseases. Experimental findings from an up-to-date search showed that Hyp possesses hepatoprotective, antiviral, antisteatotic, anti-inflammatory, antifibrotic, and anticancer activities in cellular and animal models related to liver dysfunction by enhancing antioxidant responses. In particular, hepatocellular antioxidant defense via activation of erythroid-related nuclear factor 2 by Hyp chiefly explains how this compound acts as a therapeutic agent in liver diseases. Thus, this review emphasizes the therapeutic potential of Hyp as a strong antioxidative substance that plays a crucial role in the regulation of various liver disorders during their pathogenesis.

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Metabolomics analysis reveals the protective effect of quercetin‐3‐O‐galactoside (Hyperoside) on liver injury in mice induced by acetaminophen

Abstract: Irregular use of nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs, and herbs are the main causes of drug-induced liver injury. Acetaminophen (APAP) is a widely used

Cited by 20 publications

References 31 publications

Nutritional and Bioactive Characterization of Sicana odorifera Naudim Vell. Seeds By-Products and Its Potential Hepatoprotective Properties in Swiss Albino Mice

Nutritional and Bioactive Characterization of Sicana odorifera Naudim Vell. Seeds By-Products and Its Potential Hepatoprotective Properties in Swiss Albino Mice

Metabolites of the Soy Sauce Koji Making with Aspergillus niger and Aspergillus oryzae

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

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