Metabolomics and metabonomics

Ramsden, Jeremy J.

doi:10.1007/978-1-4020-2950-9_15

Cited by 2 publications

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“…Metabolomics is the systematic acquisition of small molecules produced by a biological system at a certain point in time. Increasing resolution of the data acquired by state-of-the-art technologies produces an expanding volume of data hereby [ 274 ]. To evaluate these data in the best way, dereplication using bioinformatics tools is indispensable [ 275 ].…”

Section: Metabolomics For the Discovery Of New Antibiotics Producementioning

confidence: 99%

Concepts and Methods to Access Novel Antibiotics from Actinomycetes

et al. 2018

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Actinomycetes have been proven to be an excellent source of secondary metabolites for more than half a century. Exhibiting various bioactivities, they provide valuable approved drugs in clinical use. Most microorganisms are still untapped in terms of their capacity to produce secondary metabolites, since only a small fraction can be cultured in the laboratory. Thus, improving cultivation techniques to extend the range of secondary metabolite producers accessible under laboratory conditions is an important first step in prospecting underexplored sources for the isolation of novel antibiotics. Currently uncultured actinobacteria can be made available by bioprospecting extreme or simply habitats other than soil. Furthermore, bioinformatic analysis of genomes reveals most producers to harbour many more biosynthetic gene clusters than compounds identified from any single strain, which translates into a silent biosynthetic potential of the microbial world for the production of yet unknown natural products. This review covers discovery strategies and innovative methods recently employed to access the untapped reservoir of natural products. The focus is the order of actinomycetes although most approaches are similarly applicable to other microbes. Advanced cultivation methods, genomics- and metagenomics-based approaches, as well as modern metabolomics-inspired methods are highlighted to emphasise the interplay of different disciplines to improve access to novel natural products.

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Section: Metabolomics For the Discovery Of New Antibiotics Producementioning

confidence: 99%

Concepts and Methods to Access Novel Antibiotics from Actinomycetes

et al. 2018

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Metabonomics and Toxicology

Zhao

Hartung

2015

Methods in Molecular Biology

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Being an emerging field of "omics" research, metabonomics has been increasingly used in toxicological studies mostly because this technology has the ability to provide more detailed information to elucidate mechanism of toxicity. As an interdisciplinary field of science, metabonomics combines analytical chemistry, bioinformatics, statistics, and biochemistry. When applied to toxicology, metabonomics also includes aspects of patho-biochemistry, systems biology, and molecular diagnostics. During a toxicological study, the metabolic changes over time and dose after chemical treatment can be monitored. Therefore, the most important use of this emerging technology is the identification of signatures of toxicity-patterns of metabolic changes predictive of a hazard manifestation. This chapter summarizes the current state of metabonomics technology and its applications in various areas of toxicological studies.

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Metabolomics and metabonomics

Cited by 2 publications

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Concepts and Methods to Access Novel Antibiotics from Actinomycetes

Concepts and Methods to Access Novel Antibiotics from Actinomycetes

Metabonomics and Toxicology

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