Metabolomics and Proteomics Annotate Therapeutic Mechanisms of Geniposide

High-Throughput Metabolomics for Identification of Metabolic Pathways and Deciphering the Effect Mechanism of Dioscin on Rectal Cancer From Cell Metabolic Profiles Coupled With Chemometrics Analysis

“…As a final downstream product in vivo, metabolome reflects the changes of enzyme level, cellular regulation, signaling pathway control, genetic variations, and catabolic and anabolic reactions in health and physiopathologic state (Dong et al, 2012). Metabolomics has the ability to simultaneously measure thousands of metabolites to characterize the global and dynamic profiling of disease occurrence and development by distinct association of liquid (LC) and gas (GC) chromatography binded with mass spectrometry (MS) or nuclear magnetic resonance (NMR) (Sun et al, 2013;Zhang et al, 2015a). To date, more valuable information about biomarker findings for forecasting, early diagnosis, accurate curing, and prognosis has been successfully brought about (Wu et al, 2011;Zhang et al, 2014c;Wang et al, 2015;Liu et al, 2018).…”

Exploring potential biomarkers of coronary heart disease treated by Jing Zhi Guan Xin Pian using high-throughput metabolomics

“…Metabolomics plays an important role in exploring metabolic disorder metabolism-related diseases, [18][19][20][21][22][23][24][25][26][27][28][29] biomarkers identication [30][31][32][33][34][35][36][37][38] and response to treatment. [39][40][41][42][43][44][45][46] In this study, differences in biomarkers in urine between the model group and the blank group were successfully analyzed and 25 biomarkers were ultimately associated with the CHD model.…”

Exploring metabolic biomarkers and regulation pathways of acute pancreatitis using ultra-performance liquid chromatography combined with a mass spectrometry-based metabolomics strategy

“…In the oxidative stress system analysis, an increase in the cytokines MPO and MDA, which promote oxidative stress in AP rats, and a decrease in the cytokine SOD, which attenuates oxidative stress, indicated that the model rats were in an oxidative stress-enhancing state. 49,50 This is one of the causes of secondary tissue damage. The above results were similarly veried from pathological analysis of sections of pancreas.…”