Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice

Lu, Youyi; Sun, Jinchun; Petrova, Katya V.; Yang, Xi; Greenhaw, James; Salminen, William F.; Beger, Richard D.; Schnackenberg, Laura K.

doi:10.1016/j.fct.2013.09.025

Cited by 45 publications

(30 citation statements)

References 66 publications

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“…Previous studies have shown that there is a higher content of polyphenol and antioxidant activity in white tea than green tea [17] but our result did not show any significant difference in total antioxidant capacity between white tea and green tea [15,29].…”

Section: Discussioncontrasting

confidence: 55%

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Serki¹

2017

AJCEM

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Abstract:Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicininduced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of druginduced liver injury.

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Section: Discussioncontrasting

confidence: 55%

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Serki¹

2017

AJCEM

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“…Some of the variation in toxicity observed in human populations may be explained by a synergistically toxic effect of mitochondrial stress and EGCG ingestion. One example of such an interaction is recent work demonstrating that green tea extract can potentiate acetaminophen-induced liver injury in mice and that this may result from effects on mitochondrial function (Lu et al, 2013; Salminen et al, 2012). Furthermore, EGCG has been shown to inhibit mitochondrial respiratory complexes in swelling, but not in healthy mitochondria, suggesting that environmental stressors may potentiate EGCG-induced hepatocellular injury (Weng et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

Church

Gatti

Urban

et al. 2015

Food and Chemical Toxicology

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Consumer use of herbal and dietary supplements has recently grown in the United States and, with increased use, reports of rare adverse reactions have emerged. One such supplement is green tea extract, containing the polyphenol epigallocatechin gallate (EGCG), which has been shown to be hepatotoxic at high doses in animal models. The Drug-Induced Liver Injury Network has identified multiple patients who have experienced liver injury ascribed to green tea extract consumption and the relationship to dose has not been straightforward, indicating that differences in sensitivity may contribute to the adverse response in susceptible people. The Diversity Outbred (DO), a genetically heterogeneous mouse population, provides a potential platform for study of interindividual toxicity responses to green tea extract. Within the DO population, an equal exposure to EGCG (50 mg/kg; daily for three days) was found to be tolerated in the majority of mice; however, a small fraction of the animals (16%; 43/272) exhibited severe hepatotoxicity (10–86.8% liver necrosis) that is analogous to the clinical cases. The data indicate that the DO mice may provide a platform for informing risk of rare, adverse reactions that may occur in consumer populations upon ingestion of concentrated herbal products.

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“…The present study illustrated the protective property of C.sativus (petal and stigma), Z.jujuba and B.vulgaris against acetaminophen and rifampicin induced hepatic damage in rats. Acetaminophen and rifampicin overdoses caused acute liver injury and fatal hepatic necrosis through inducing oxidative stress or decreasing total antioxidant capacity [25][26][27][28][29]. These chemical drugs are widely metabolized by the liver and elevate multiple hepatic enzymes.…”

Section: Discussionmentioning

confidence: 99%

An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

et al. 2016

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Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice

Cited by 45 publications

References 66 publications

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

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