Metabolomics fingerprinting of the human seminal plasma of asthenozoospermic patients

Gilany, Kambiz; Moazeni-Pourasil, Roudabeh Sadat; Jafarzadeh, Naser; Savadi-Shiraz, Elham

doi:10.1002/mrd.22284

Cited by 42 publications

(30 citation statements)

References 17 publications

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“…However, various molecular approaches, such as metabolomics, have provided more in depth understanding of mechanisms causing male infertility (Deepinder et al 2007;Aitken, 2010). Metabolomics has promise in identifying potential biomarkers of male fertility and infertility (Gilany et al, 2014;Goodacre et al, 2004;Deepinder et al, 2007;Kovac et al, 2013). The presence or changes in specific metabolites could be related to male gamete functions, perhaps enabling evidence-based techniques to prevent or mitigate infertility (Aitken, 2010).…”

Section: Metabolomics and Reproductive Biologymentioning

confidence: 99%

Seminal plasma proteins and metabolites: effects on sperm function and potential as fertility markers

Moura¹,

Memili²,

Portela³

et al. 2018

Anim Reprod

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Molecular components of sperm and in the media surrounding them influence male fertility. In this regard, seminal plasma proteins and metabolites modulate various reproductive events, including sperm motility and capacitation, cell protection, acrosome reaction, fertilization and embryonic development. Empirical associations between seminal proteins and metabolites and fertility indicate that these molecules are potential molecular markers of male reproductive status in cattle and other species.

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Section: Metabolomics and Reproductive Biologymentioning

confidence: 99%

Seminal plasma proteins and metabolites: effects on sperm function and potential as fertility markers

Moura¹,

Memili²,

Portela³

et al. 2018

Anim Reprod

View full text Add to dashboard Cite

show abstract

“…This is surprising given the potential of metabolomics to address many important questions in livestock and animal science. In particular, the power of metabolomics to non-invasively detect subtle phenotypic changes, innate phenotypic propensities and dietary responses makes it an ideal tool for livestock research, breeding and assessment [13; 14; 15; 16; 17; 18; 19]. Recently, there have been a number of papers in livestock metabolomics that have generated compelling results showing how metabolomics and metabolite-based phenotyping (metabotyping) can help farmers, veterinarians, livestock researchers and the livestock industry.…”

Section: Introductionmentioning

confidence: 99%

Livestock metabolomics and the livestock metabolome: A systematic review

Goldansaz¹,

Guo²,

Sajed³

et al. 2017

PLoS ONE

269

247

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Metabolomics uses advanced analytical chemistry techniques to comprehensively measure large numbers of small molecule metabolites in cells, tissues and biofluids. The ability to rapidly detect and quantify hundreds or even thousands of metabolites within a single sample is helping scientists paint a far more complete picture of system-wide metabolism and biology. Metabolomics is also allowing researchers to focus on measuring the end-products of complex, hard-to-decipher genetic, epigenetic and environmental interactions. As a result, metabolomics has become an increasingly popular “omics” approach to assist with the robust phenotypic characterization of humans, crop plants and model organisms. Indeed, metabolomics is now routinely used in biomedical, nutritional and crop research. It is also being increasingly used in livestock research and livestock monitoring. The purpose of this systematic review is to quantitatively and objectively summarize the current status of livestock metabolomics and to identify emerging trends, preferred technologies and important gaps in the field. In conducting this review we also critically assessed the applications of livestock metabolomics in key areas such as animal health assessment, disease diagnosis, bioproduct characterization and biomarker discovery for highly desirable economic traits (i.e., feed efficiency, growth potential and milk production). A secondary goal of this critical review was to compile data on the known composition of the livestock metabolome (for 5 of the most common livestock species namely cattle, sheep, goats, horses and pigs). These data have been made available through an open access, comprehensive livestock metabolome database (LMDB, available at http://www.lmdb.ca). The LMDB should enable livestock researchers and producers to conduct more targeted metabolomic studies and to identify where further metabolome coverage is needed.

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“…It has been reported that asthenozoospermic men represent significant change at metabolome level compared to fertile men, based on metabolomics fingerprinting studying asthenozoospermic patient seminal plasma. Additionally, an imbalance of ROS was observed in the asthenozoospermic compared to seminal plasma of fertile men (Gilany et al ., ).…”

Section: Metabolomic Biomarkers In Infertile Menmentioning

confidence: 97%

Metabolomics: a state-of-the-art technology for better understanding of male infertility

2015

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Male factor infertility affects approximately half of the infertile couples, in spite of many years of research on male infertility treatment and diagnosis; several outstanding questions remain to be addressed. In this regard, metabolomics as a novel field of omics has been suggested to be applied for male infertility problems. A variety of terms associated with metabolite quantity and quality have been established to demonstrate mixtures of metabolites. Despite metabolomics and metabolite analyses have been around more than decades, a limited number of studies concerning male infertility have been carried out. In this review, we summarised the latest finding in metabolomics techniques and metabolomics biomarkers correlated with male infertility. The rapid progress of a variety of metabolomics platforms, such as nonoptical and optical spectroscopy, could ease separation, recognition, classification and quantification of several metabolites and their metabolic pathways. Here, we recommend that the novel biomarkers determined in the course of metabolomics analysis may stand for potential application of treatment and future clinical practice.

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Metabolomics fingerprinting of the human seminal plasma of asthenozoospermic patients

Cited by 42 publications

References 17 publications

Seminal plasma proteins and metabolites: effects on sperm function and potential as fertility markers

Seminal plasma proteins and metabolites: effects on sperm function and potential as fertility markers

Livestock metabolomics and the livestock metabolome: A systematic review

Metabolomics: a state-of-the-art technology for better understanding of male infertility

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