Metabolomics in Vitamin Status Assessment

Varaeva, Y.; Livantsova, E.N.; Украинец, И. В.; Kosyura, S.D.; Starodubova, A. V.

doi:10.2174/1381612824666180912142743

Cited by 6 publications

(5 citation statements)

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“…In this study, we comprehensively reviewed nutritional metabolomics studies of breast cancer as epidemiologic studies to determine diet-cancer associations by measuring nutritional metabolites. In nutritional metabolomics, high-resolution chemical analysis together with statistical tools [52] has been used to determine chemicals in foods [43,53], recognize food byproducts in tissues and/or biofluids [12], determine macro-micronutrient imbalances [54,55], track biochemical reactions to dietary interventions [27], trace dietary patterns/habits [29], and instruct the advancement of diet therapies [56].…”

Section: Metabolomics and Nutritional Metabolomics: How Will They Be ...mentioning

confidence: 99%

Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review

Vahid,

Hajizadeghan,

Khodabakhshi

2023

Biomedicines

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Breast cancer is one of the most common types of cancer in women worldwide, and its incidence is increasing. Diet has been identified as a modifiable risk factor for breast cancer, but the complex interplay between diet, metabolism, and cancer development is not fully understood. Nutritional metabolomics is a rapidly evolving field that can provide insights into the metabolic changes associated with dietary factors and their impact on breast cancer risk. The review’s objective is to provide a comprehensive overview of the current research on the application of nutritional metabolomics in understanding the relationship between diet and breast cancer. The search strategy involved querying several electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar. The search terms included combinations of relevant keywords such as “nutritional metabolomics”, “diet”, “breast cancer”, “metabolites”, and “biomarkers”. In this review, both in vivo and in vitro studies were included, and we summarize the current state of knowledge on the role of nutritional metabolomics in understanding the diet–breast cancer relationship, including identifying specific metabolites and metabolic pathways associated with breast cancer risk. We also discuss the challenges associated with nutritional metabolomics research, including standardization of analytical methods, interpretation of complex data, and integration of multiple-omics approaches. Finally, we highlight future directions for nutritional metabolomics research in studying diet–breast cancer relations, including investigating the role of gut microbiota and integrating multiple-omics approaches. The application of nutritional metabolomics in the study of diet–breast cancer relations, including 2-amino-4-cyano butanoic acid, piperine, caprate, rosten-3β,17β-diol-monosulfate, and γ-carboxyethyl hydrochroman, among others, holds great promise for advancing our understanding of the role of diet in breast cancer development and identifying personalized dietary recommendations for breast cancer prevention, control, and treatment.

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Section: Metabolomics and Nutritional Metabolomics: How Will They Be ...mentioning

confidence: 99%

Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review

Vahid,

Hajizadeghan,

Khodabakhshi

2023

Biomedicines

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“…Both untargeted and targeted metabolomics have their advantages and disadvantages, but given the importance attached to bioactive compound identification and quantification, there is a growing preference for quantitative metabolomics in many areas of food science and nutrition research. Indeed, targeted, quantitative metabolomics is now widely used in food composition analysis [8,20,21], the identification of BFIs [13,22], the detection and monitoring of nutritional deficiencies or metabolic/nutrient disorders [10,11,23], the estimation of dietary intake [24][25][26], and the development of dietary recommendations for wellness and chronic disease prevention [14].…”

Section: Metabolomics and Nutritional Sciencementioning

confidence: 99%

“…Metabolomics is a field of omics science that uses cuttingedge analytical chemistry techniques and advanced computational methods to characterize complex biochemical mixtures [7]. It can be used to comprehensively characterize the thousands of chemicals in foods [8], to identify food byproducts in human biofluids or tissues [9], to characterize nutrient deficiencies or excesses [10,11], to monitor biochemical responses to dietary interventions [12], to track long-term or short-term dietary habits [13], and to guide the development of nutritional therapies [14].…”

Section: Introductionmentioning

confidence: 99%

Applications of Metabolomics to Precision Nutrition

et al. 2021

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Background: For thousands of years, disabilities due to nutrient deficiencies have plagued humanity. Rickets, scurvy, anemia, stunted growth, blindness, and mental handicaps due to nutrient deficiencies affected up to 1/10 of the world’s population prior to 1900. The discovery of essential amino acids, vitamins, and minerals, in the early 1900s, led to a fundamental change in our understanding of food and a revolution in human health. Widespread vitamin and mineral supplementation, the development of recommended dietary allowances, and the implementation of food labeling and testing along with significant improvements in food production and food quality have meant that nutrient-related disorders have almost vanished in the developed world. The success of nutritional science in preventing disease at a population-wide level is one of the great scientific triumphs of the 20th century. The challenge for nutritional science in the 21st century is to understand how to use nutrients and other food constituents to enhance human health or prevent disease at a more personal level. This is the primary goal of precision nutrition. Summary: Precision nutrition is an emerging branch of nutrition science that aims to use modern omics technologies (genomics, proteomics, and metabolomics) to assess an individual’s response to specific foods or dietary patterns and thereby determine the most effective diet or lifestyle interventions to prevent or treat specific diseases in that individual. Metabolomics is vital to nearly every aspect of precision nutrition. It can be used to comprehensively characterize the thousands of chemicals in foods, to identify food byproducts in human biofluids or tissues, to characterize nutrient deficiencies or excesses, to monitor biochemical responses to dietary interventions, to track long-term or short-term dietary habits, and to guide the development of nutritional therapies. In this review, we will describe how metabolomics has been used to advance the field of precision nutrition by providing some notable examples or use cases. First, we will describe how metabolomics helped launch the field of precision nutrition through the diagnosis and dietary therapy of individuals with inborn errors of metabolism. Next, we will describe how metabolomics is being used to comprehensively characterize the full chemical complexity of many key foods, and how this is revealing much more about nutrients than ever imagined. Third, we will describe how metabolomics is being used to identify food consumption biomarkers and how this opens the door to a more objective and quantitative assessments of an individual’s diet and their response to certain foods. Finally, we will describe how metabolomics is being coupled with other omics technologies to develop custom diets and lifestyle interventions that are leading to positive health benefits. Key Message: Metabolomics is vital to the advancement of nutritional science and in making the dream of precision nutrition a reality.

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“…Some others are unstable in the presence of oxygen or light or diverse temperatures or under other analytical conditions, which can cause a significant problem during sample preparation as well as instrumental analysis [90,92]. For example, sample preparation for detection of vitamins is very sensitive as degradation may happen in the presence of direct light [93]. Thus, due to this extensive diversity, there is currently no universal analytical method which has the sensitivity and specificity of identifying and quantifying the full scope of all existing metabolites present in the broad range of commonly used biological samples [6,88].…”

Section: Translational Challenges In Metabolomicsmentioning

confidence: 99%

Translational Metabolomics: Current Challenges and Future Opportunities

Pinu

Goldansaz

Jaine³

2019

Metabolites

157

111

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Metabolomics is one of the latest omics technologies that has been applied successfully in many areas of life sciences. Despite being relatively new, a plethora of publications over the years have exploited the opportunities provided through this data and question driven approach. Most importantly, metabolomics studies have produced great breakthroughs in biomarker discovery, identification of novel metabolites and more detailed characterisation of biological pathways in many organisms. However, translation of the research outcomes into clinical tests and user-friendly interfaces has been hindered due to many factors, some of which have been outlined hereafter. This position paper is the summary of discussion on translational metabolomics undertaken during a peer session of the Australian and New Zealand Metabolomics Conference (ANZMET 2018) held in Auckland, New Zealand. Here, we discuss some of the key areas in translational metabolomics including existing challenges and suggested solutions, as well as how to expand the clinical and industrial application of metabolomics. In addition, we share our perspective on how full translational capability of metabolomics research can be explored.

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Metabolomics in Vitamin Status Assessment

Cited by 6 publications

References 0 publications

Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review

Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review

Applications of Metabolomics to Precision Nutrition

Translational Metabolomics: Current Challenges and Future Opportunities

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