Metabolomics Tools to Study Links Between Pollution and Human Health: an Exposomics Perspective

Misra, Biswapriya B.

doi:10.1007/s40726-019-00109-4

Cited by 10 publications

(10 citation statements)

References 92 publications

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“…Generally speaking, past studies have typically focused on measuring the chemical space (i.e., metabolome and now, exposome) in human samples and habitats using spectrometry tools such as mass-spectrometry (MS) hyphenated with diverse chromatography approaches as mentioned elsewhere (Misra, 2019). Primarily these include, gas chromatography (GC)-MS, liquid chromatography (LC)-MS, capillary electrophoresis (CE)-MS etc.…”

Section: Tools and Techniques To Capture The Exposotypes Analytical Pmentioning

confidence: 99%

“…or without chromatography, i.e., direct injection (DI)-MS, flow injection analysis (FIA)-MS, imaging-MS and spectroscopy approaches such as nuclear magnetic resonance spectroscopy (NMR), Raman spectroscopy, infra-red (IR) spectroscopy etc. Other MS-based technologies are equipped to provide increased overall measurement dynamic range of environmental chemicals from polar to highly non-polar chemicals from a wide variety of matrices (Misra, 2019).…”

Section: Tools and Techniques To Capture The Exposotypes Analytical Pmentioning

confidence: 99%

“…These exposures around human civilization are not only natural but also engineered/anthropogenic factors that affect us every moment, either physically (i.e., noise) or chemically (i.e., pollutants). Xenobiotics such as pharmaceuticals and personal care products (PPCPs), pesticides and insecticides, plant-, bacteria-and food-derived compounds, food additives, surfactants, solvents, synthetic and industrial chemicals, and microbial compounds constitute a huge chunk of human chemical exposome (Misra, 2019). In a recent review (Vermeulen et al, 2020), the major categories of "chemical exposome" were identified as diet, drug use, smoking, alcohol use under lifestyle factors.…”

Section: Introductionmentioning

confidence: 99%

“…For the purpose of this review article, the term "environment" refers only to specify the "macroenvironment" (i.e., the habitat and dwelling space) and not the "microenvironment" such as those inside cells, organelles, and tissues etc. as noted elsewhere (Misra, 2019). Also, the term "exposome" is used in this review to exclusively include exogenous chemicals, and not the physical exposures such as noise, radiation, water, soil, education, societal, spiritual, occupational, and those different from the internal exposome (i.e., metabolism, physical activity, genetics, endocrine factors, inflammation, chronic diseases, stress etc.)…”

Section: Introductionmentioning

confidence: 99%

“…Also, the term "exposome" is used in this review to exclusively include exogenous chemicals, and not the physical exposures such as noise, radiation, water, soil, education, societal, spiritual, occupational, and those different from the internal exposome (i.e., metabolism, physical activity, genetics, endocrine factors, inflammation, chronic diseases, stress etc.) (Misra, 2019).…”

Section: Introductionmentioning

confidence: 99%

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The Chemical Exposome of Human Aging

Misra

2020

Front. Genet.

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Aging is an inevitable biological phenomenon displayed by single cells and organs to entire organismal systems. Aging as a biological process is characterized as a progressive decline in intrinsic biological function. Understanding the causative mechanisms of aging has always captured the imagination of researchers since time immemorial. Although both biological and chronological aging are well defined and studied in terms of genetic, epigenetic, and lifestyle predispositions, the hallmarks of aging in terms of small molecules (i.e., endogenous metabolites to chemical exposures) are limited to obscure. On top of the endogenous metabolites leading to the onset and progression of healthy aging, human beings are constantly exposed to a natural and anthropogenic “chemical” environment round the clock, from conception till death, affecting one’s physiology, health and well-being, and disease predisposition. The research community has started gaining sizeable insights into deciphering the aging factors such as immunosenescence, nutrition, frailty, inflamm-aging, and diseases till date, without much input from their interaction with exogenous chemical exposures. The “exposome” around us, mostly, accelerates the process of aging by affecting the internal biological pathways and signaling mechanisms that result in the deterioration of human health. However, the entirety of exposome on human aging is far from established. This review intends to catalog the known and established associations of the exposome from past studies focusing on aging in humans and other model organisms. Further discussed are the current technologies and informatics tools that enable the study of aging exposotypes, and thus, provide a window of opportunities and challenges to study the “aging exposome” in granular details.

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Section: Tools and Techniques To Capture The Exposotypes Analytical Pmentioning

confidence: 99%

Section: Tools and Techniques To Capture The Exposotypes Analytical Pmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Chemical Exposome of Human Aging

Misra

2020

Front. Genet.

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Untargeted and targeted analysis of sarin poisoning biomarkers in rat urine by liquid chromatography and tandem mass spectrometry

et al. 2021

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Metabolomics in chemical risk analysis – A review

Hernández‐Mesa

Bizec

2021

Analytica Chimica Acta

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Food safety has become a major issue worldwide and, in particular, detecting the presence of toxins, contaminants or residues of chemical substances along the food chain and in fine in foods constitutes a strong consumers demand. In general, all these substances and the corresponding metabolites of interest are analyzed using efficient targeted methodologies. However, in some cases these targeted approaches do not allow the detection of emerging compounds or practices, and therefore new approaches and strategies are required. Thus, the study of physiological perturbations induced by exposure to a given chemical substance has emerged as an interesting alternative approach to apply in chemical food safety.This review focuses on describing significant applications of metabolomics in the field of risk analysis from a chemical food safety perspective. The different risk assessment steps, including hazard identification, doseresponse assessment and exposure assessment, and risk management are addressed through various examples to illustrate that such an approach is fit-for-purpose and meets the expectations and requirements of chemical risk analysis. It can be considered as an innovative tool for predicting the probable occurrence and nature of risks, while addressing the current challenges of chemical risk analysis (e.g. replacement, reduction and refinement (3R) of animal testing, effects of exposure to chemical mixtures at low doses, etc.), and with the aim of responding to global food safety issues and anticipating human health problems.

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Metabolomics Tools to Study Links Between Pollution and Human Health: an Exposomics Perspective

Cited by 10 publications

References 92 publications

The Chemical Exposome of Human Aging

The Chemical Exposome of Human Aging

Untargeted and targeted analysis of sarin poisoning biomarkers in rat urine by liquid chromatography and tandem mass spectrometry

Metabolomics in chemical risk analysis – A review

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