Metabonomics analysis of Zi goose follicular granulosa cells using <i>ENO1</i> gene expression interference

Ji, Hong; Guo, Wenjin; Niu, Chunyang; Li, Yue; Lian, Shuai; Zhan, Xuelong; Guo, Jiang; Li, Zhen; Yang, Huanmin; Li, Shize; Wang, Jianfa

doi:10.1111/jpn.13254

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…The subjects were Zi geese (a small-type breed, Anser cygnoides L. ) that were approximately one year in age. The Zi goose is native to North-East China and is noted for its high egg production ( Ji et al., 2020 ). The experiment consisted of 3 flocks.…”

Section: Methodsmentioning

confidence: 99%

The association of social rank with paternity efficiency in competitive mating flocks of Zi goose ganders (Anser cygnoides L.)

Zhang¹,

Liu²,

Li³

et al. 2021

Poultry Science

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The purpose of this study was to investigate the influence of social rank ( SR ) on paternity efficiency ( PE ) in competitive mating flocks of geese. Thirty ganders and 150 geese (Zi geese, Anser cygnoides L.) aged approximately one, were divided into 3 groups. Flock 1 included 10 ganders and 50 female geese, flock 2 included 11 ganders and 55 female geese, and flock 3 included 9 ganders and 45 female geese. The frequency of the agonistic behavioral interactions ( ABI ) of the ganders and mating activity ( MA ) were video recorded in each flock. The SR of each gander was determined by the frequency of ABI with a score of 1 to 3 (1 being the dominant and 3 the most subordinate). To clarify the difference between being dominant and submissive, we collapsed rank 2 and rank 3 into a “subordinate” category. In total, 280 eggs were collected, and 219 goslings were hatched. Parent–offspring relationships among 399 individuals from the 2 generations were identified via 20 microsatellite markers, and the PE of each gander was calculated. There was no significant difference in individual body weight and semen quality factor among the different SR groups (dominant and subordinate), and the SR of the ganders was significantly correlated to PE for the 3 flocks. Goslings of high-ranking ganders contributed 48.68% in flock 1, 37.50% in flock 2, and 47.62% in flock 3. Approximately 45% of all goslings were sired by the 7 dominant ganders of the 30 total ganders across the 3 flocks. As SR has been shown to be heritable in geese, the selection of high-ranking ganders might be an effective way to improve reproductive efficiency in commercial geese flocks.

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Section: Methodsmentioning

confidence: 99%

The association of social rank with paternity efficiency in competitive mating flocks of Zi goose ganders (Anser cygnoides L.)

Zhang¹,

Liu²,

Li³

et al. 2021

Poultry Science

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“…The expression of MDM2 is affected by folic acid and can inhibit the effects of ADR and p53 (49)(50)(51). ENO1 can regulate the metabolism of vitamin D3 and indole (52). EEF2 plays a vital role in the tumorigenesis and progression of some tumors (53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%

Development of A Vitamin-Related Gene Signature to Predict the Immune Characteristics and Prognosis of Glioma

Zhang¹,

Liang²,

Guan³

et al. 2020

Preprint

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Background: Vitamins not only play a pivotal role in maintaining homeostasis of the body, but also have complex impacts on the occurrence and progression of tumors. However, the effects of vitamins on glioma and the underlying mechanism have not been fully elucidated. Methods: Vitamin -related genes were extracted from the Molecular Signature Database v7.1 (MSigDB). The overlapping overall survival (OS)-related genes in The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), and GSE16011 cohorts screened out by univariate COX regression analysis were utilized to construct a risk model based on the TCGA cohort via random survival forest analysis and multivariate COX regression analysis. The powerful prognostic predictive potential of the vitamin-related risk signature was verified by Kaplan–Meier survival analysis and receiver operating characteristic (ROC) analysis in the three datasets. The ssGSEA method of the GSVA package was used for functional enrichment and immune cell component analyses. ESTIMATE score analysis was used for auxiliary analysis of glioma immune characteristics. A nomogram was constructed and assessed based on the TCGA dataset.Results: The vitamin-related six-gene (POSTN, IRX5, EEF2, RAB27A, MDM2, and ENO1) risk signature constructed based on the TCGA dataset accurately predicted the outcomes of glioma patients and credibly distinguished between different levels and molecular subtypes of glioma in the TCGA, CGGA, and GSE16011 cohorts. Gliomas with high risk scores exhibited high immune scores, low tumor purity, and immunosuppressive features. The nomogram constructed by combining the vitamin-related risk signature and clinicopathological factors precisely predicted the 1-, 3-, and 5-year OS of glioma patients.Conclusions: Our study revealed that the vitamin-related six-gene risk signature, as an independent prognostic factor, could accurately distinguish the grade, molecular subtype, and immune characteristics of glioma.

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“…Natural and artificial directional selection has resulted in significant genetic and phenotypic differences between poultry breeds. Zi goose is a famous local breed originating from northeast China with high annual egg production characteristics (Ji et al., 2020). Except for the Yili goose, all other Chinese domestic goose breeds originated from the swan goose ( Anser cygnoides ) (Li et al., 2011).…”

Section: Figurementioning

confidence: 99%

Integrated analysis of whole genome and transcriptome sequencing uncovers genetic differences between Zi goose and Xianghai flying goose

Ni,

Zhang,

Yang

et al. 2023

Animal Genetics

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Zi goose is a famous indigenous breed originating from northeast China with high annual egg production. Xianghai flying goose is a composite breed and is bred by crosses of the wild swan goose and the Zi goose. Our previous study revealed significant differences in muscle fiber characteristics between the two populations. Here, we aimed to reveal the underlying genetic basis of the above phenotype differences through whole‐genome and transcriptome analysis. A total of 20 blood samples (10 Zi geese and 10 Xianghai flying geese) were used for whole genome sequencing, and eight breast muscle tissue samples (four Zi geese and four Xianghai flying geese) were used for RNA sequencing. Using the FST and XP‐EHH analysis, some highly differentiated genome regions annotated with egg production (RORB, WNT4, BMPR1B) and breast muscle development (WNT7B) between the two populations were detected. RNA‐sequencing analysis revealed differentially expressed genes related to muscle development (IGF1, PAX7). Moreover, several genes were detected by both genome and transcriptome analysis, and some of them were reported to be associated with muscle growth (SLIT2, PREX1) and intramuscular fat (COL6A1). These findings will help researchers better understand the genetic basis related to egg production and muscle development in geese.

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Metabonomics analysis of Zi goose follicular granulosa cells using ENO1 gene expression interference

Cited by 3 publications

References 49 publications

The association of social rank with paternity efficiency in competitive mating flocks of Zi goose ganders (Anser cygnoides L.)

The association of social rank with paternity efficiency in competitive mating flocks of Zi goose ganders (Anser cygnoides L.)

Development of A Vitamin-Related Gene Signature to Predict the Immune Characteristics and Prognosis of Glioma

Integrated analysis of whole genome and transcriptome sequencing uncovers genetic differences between Zi goose and Xianghai flying goose

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