2005
DOI: 10.1016/j.neuropharm.2005.06.007
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Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats

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Cited by 120 publications
(100 citation statements)
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“…It seems unlikely that the reductions in responding on the active and inactive levers in these experiments reflected a generalised suppression of behaviour since, as previously reported (Tessari et al 2004), pretreatment with MPEP did not reduce spontaneous locomotor activity (Tronci et al 2010). Additionally, MPEP pretreatment does not diminish operant responding for a food reward (Bespalov et al 2005;Liechti and Markou 2007a;Tronci et al 2010). …”
Section: The Role Of Contextual Stimuli In Psychopharmacological Respsupporting
confidence: 53%
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“…It seems unlikely that the reductions in responding on the active and inactive levers in these experiments reflected a generalised suppression of behaviour since, as previously reported (Tessari et al 2004), pretreatment with MPEP did not reduce spontaneous locomotor activity (Tronci et al 2010). Additionally, MPEP pretreatment does not diminish operant responding for a food reward (Bespalov et al 2005;Liechti and Markou 2007a;Tronci et al 2010). …”
Section: The Role Of Contextual Stimuli In Psychopharmacological Respsupporting
confidence: 53%
“…Additionally, in experimental animals high rates of responding for nicotine are only observed in the drug infusions are paired with a sensory stimulus (Caggiula et al Following extinction of responding for nicotine, the presentation of a cue previously paired with the nicotine infusions elicits reinstatement of responding (LeSage et al 2004;Liu et al 2007). Cueinduced reinstatement of nicotine-seeking behaviour is attenuated by the prior administration of the mGluR5 antagonist MPEP (Bespalov et al 2005). The effect of the antagonist was selective to the extent that it had no significant effect on the reinstatement of cue-induced food seeking behaviour.…”
Section: Mglur5 Receptors and Models Of Relapsementioning
confidence: 96%
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“…The EVH1 domain exhibits a high degree of similarity across Homer isoforms and is essential for Homer interactions with a proline-rich sequence (PPSPF) displayed by proteins regulating drug-induced alterations in neuronal morphology, synaptic architecture, and glutamate receptor signaling/intracellular calcium dynamics. Of particular relevance to drug-induced neuroplasticity [e.g., 20,73,74,[78][79][80][81][82][89][90][91][92][93][94][95][96][97][98][99][100][123][124][125][126][127][128][129][130], these proteins include the mGluR1a and mGluR5 subtypes of Group 1 metabotropic glutamate receptors (mGluRs) [34,102,104,107,[131][132][133][134][135][136][137], the NMDA glutamate receptor scaffolding protein Shank [38,132,138,139], the inositol-1,4,5-triphosphate (IP3) receptor, a down-stream mediator of Group1 mGluR signaling [133,[140]…”
Section: Molecular Aspects Of Homer Proteinsmentioning
confidence: 99%
“…In addition, MPEP selectively decreased nicotine-but not food-maintained responding in rats (Paterson et al, 2003;Tessari et al, 2004), and the motivation to self-administer nicotine, as assessed with the progressive ratio schedule of reinforcement (Paterson and Markou, 2005). Further, MPEP reduced nicotine-, cue-and schedule-induced reinstatement of nicotine seeking in rats (Bespalov et al, 2005;Tessari et al, 2004). Thus, blockade of mGlu5 receptors decreases the reinforcing effects of nicotine and may lead to decreases in tobacco smoking in humans.…”
Section: Introductionmentioning
confidence: 96%