Metachronous Granular Cell Tumor of the Descending Colon

Shrestha, Binav; Khalid, Mazin; Gayam, Vijay; Mukhtar, Osama; Thapa, Shivani; Mandal, Amrendra; Kaler, Jaspreet; Khalid, Mowyad; Garlapati, Pavani; Iqbal, Shamah; Posner, Gerald

doi:10.14740/gr1045w

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…6 The granular cell tumor, in this case, is a malignant granular cell tumor. We did not come to a malignant conclusion from the Fanburg-Smith criteria, as in the case reported by Shrestha, et al (2018), who concluded that the lesion was malignant not based on the Fanburg-Smith criteria. 16 Although microscopic observations based on the Fanburg-Smith criteria do not support malignancy, metastases indicate the nature of a granular cell tumor.…”

Section: Discussioncontrasting

confidence: 52%

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Is Docetaxel the Main Therapy for Lung Metastasis in Granular Cell Tumors?

Pramono

Setijadi

Sutanto

et al. 2023

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Introduction: A granular cell tumor is a rare neoplasm originating from mesenchymal tissue. Malignant granular cell tumors have a poor prognosis. The lung is one of the target organs for metastatic malignant granular cell tumors. The number of rare cases makes managing metastatic malignant granular cell tumors unknown. Case: A 19-year-old male complained of shortness of breath for two months. A liver nodule biopsy revealed poorly differentiated carcinoma metastases. Histopathology of the left manus and frontal masses found granular cell tumors—negative immunohistochemistry on S-100 and myogenin. Ki-67 obtained a value of 5%. An X-ray and contrast multislice computerized tomography (MSCT) scan showed multiple metastatic nodules. Right bronchial biopsy forceps revealed a metastatic granular cell tumor. The patient was given docetaxel for six cycles. During the post-administration of docetaxel, the patient experienced clinical and radiological improvement. Conclusion: Until 2016, only three case reports of S-100 negative granular cell tumors existed. A negative S-100 test does not rule out the diagnosis of granular cell tumors. Malignant lesions are more common in males, as in this case. The number of rare cases means that management cannot be determined. Reports of similar cases show patients surviving up to 11 years with docetaxel administration. The patient in this study has survived for one year and is complaint-free.

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Section: Discussioncontrasting

confidence: 52%

“…15 Examination by electron microscopy will be seen as polygonal cells containing eosinophilic granules resembling Schwann cells. 16 The diagnosis of granular cell tumors is still being debated. There are three reasons why the diagnosis of this tumor is debatable.…”

Section: Discussionmentioning

confidence: 99%

Is Docetaxel the Main Therapy for Lung Metastasis in Granular Cell Tumors?

Pramono

Setijadi

Sutanto

et al. 2023

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“…GCTs are uncommon tumors. They are believed to be of neuronal origin ( 57 ). They are soft tissue tumors, which are thought to be derived from Schwann cells ( 58 ).…”

Section: Background: Evidence From Previous Animal Studiesmentioning

confidence: 99%

Comments on the US National Toxicology Program technical reports on toxicology and carcinogenesis study in rats exposed to whole-body radiofrequency radiation at 900�MHz and in mice exposed to whole-body radiofrequency radiation at 1,900�MHz

Hardell

Carlberg

2018

Int J Oncol

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During the use of handheld mobile and cordless phones, the brain is the main target of radiofrequency (RF) radiation. An increased risk of developing glioma and acoustic neuroma has been found in human epidemiological studies. Primarily based on these findings, the International Agency for Research on Cancer (IARC) at the World Health Organization (WHO) classified in May, 2011 RF radiation at the frequency range of 30 kHz-300 GHz as a ‘possible’ human carcinogen, Group 2B. A carcinogenic potential for RF radiation in animal studies was already published in 1982. This has been confirmed over the years, more recently in the Ramazzini Institute rat study. An increased incidence of glioma in the brain and malignant schwannoma in the heart was found in the US National Toxicology Program (NTP) study on rats and mice. The NTP final report is to be published; however, the extended reports are published on the internet for evaluation and are reviewed herein in more detail in relation to human epidemiological studies. Thus, the main aim of this study was to compare earlier human epidemiological studies with NTP findings, including a short review of animal studies. We conclude that there is clear evidence that RF radiation is a human carcinogen, causing glioma and vestibular schwannoma (acoustic neuroma). There is some evidence of an increased risk of developing thyroid cancer, and clear evidence that RF radiation is a multi-site carcinogen. Based on the Preamble to the IARC Monographs, RF radiation should be classified as carcinogenic to humans, Group 1.

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“…Macroscopical examination of GCT tumors reveals hard lesions, isolated with a mucosal nodule or covered with normal mucosa, not distinguishable from other gastrointestinal polyps. Hence, microscopical evaluation is diriment to decide if surgical treatment is necessary [4] , [11] , [12] , [13] .…”

Section: Discussionmentioning

confidence: 99%

Granular cell tumor of the cecum: Case report of mini invasive surgical resection and review of the literature

Cantella

Evola

Stefano

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Granular Cell Tumor (GCT) is a rare lesion with unclear histogenesis, predominantly described as a skin lesion. Visceral localization of GCT is even more rare with few cases reported in the literature. Nowadays GCT guidelines are not available. Case presentation A 45-year-old Caucasian woman was visited in our surgical department for significant weight loss (about 30 kg) during the previous 6 months. Colonoscopy showed a caecal polypoid lesion that was resected with a diatermic loop and classified as GCT. Microscopically, the neoplasm partially involved the mucosa and diffusely the submucosa, extending to the endoscopic resection margins. Because of the high risk of perforation during endoscopic radicalisation attempt, the patient underwent ileocecal resection. The postoperative course was uneventful. Clinical discussion GCT is a rare soft tissue neoplasm probably deriving from Schwann cells. The main treatment for GCT is an endoscopic mucosal/submucosal resection. Nevertheless, a radicalization of the lesion through a surgical attempt should be preferred when the endoscopic procedure is linked to a high risk of perforation. It is important to distinguish GCT from other polypoid lesions of the colon, due to its malignant potential (about 2%) and its relapsing capacity when margins are involved. Conclusion GTC is a rare neoplasm and as its diagnosis is made only histologically, it should be included in differential diagnosis of colonic polypoid lesions. Surgery can be considered the best choice when an endoscopic attempt of GCT lesions is linked to a high risk of colon perforation.

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Metachronous Granular Cell Tumor of the Descending Colon

Cited by 7 publications

References 17 publications

Is Docetaxel the Main Therapy for Lung Metastasis in Granular Cell Tumors?

Is Docetaxel the Main Therapy for Lung Metastasis in Granular Cell Tumors?

Comments on the US National Toxicology Program technical reports on toxicology and carcinogenesis study in rats exposed to whole-body radiofrequency radiation at 900�MHz and in mice exposed to whole-body radiofrequency radiation at 1,900�MHz

Granular cell tumor of the cecum: Case report of mini invasive surgical resection and review of the literature

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