Instructional strategy in inclusive classrooms in higher education has not yet been able to accommodate the needs and competencies that must be achieved by students who have various characteristics, learning styles and different obstacles. The aim of this research is to explore the perceptions of student’s teacher toward the implementation of an instructional strategy model based on the brain’s natural learning system, especially its benefits for all students in inclusive classrooms in higher education. Data was col-lected through open observation and interviews on students to determine the benefits of an instructional strategy model based on the natural learning system of the brain. The data were analyzed using qualitative data analysis. The research produced four major themes consisting of emotional skills, so-cial skills, cognitive skills, self-development. The findings have implica-tions for lecturers, as well as inclusive education researchers in higher edu-cation that focus on learning in inclusive classrooms by using an instruc-tional strategy model based on the brain’s natural learning system as a suit-able instructional strategy model to be carried out in inclusive classrooms in higher education.