Metagenomic analysis of gut microbiota modulatory effects of jujube (<i>Ziziphus jujuba</i> Mill.) polysaccharides in a colorectal cancer mouse model

Ji, Xiaolong; Hou, Chunyan; Gao, Yanni; Xue, Yusheng; Yan, Yizhe; Guo, Xudan

doi:10.1039/c9fo02171j

Cited by 248 publications

(112 citation statements)

References 49 publications

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“…Actinobacteria is part of the normal GM and includes beneficial genera, for example Propionibacterium , Bifidobacterium and Corynebacterium (Tian et al , 2019). Dietary L. ruthenicum , jujube polysaccharides, fibre and probiotics have been reported to promote the growth of Actinobacteria, thereby assisting in the prevention of obesity and may have potential butyric acid‐producing bacteria (Tian et al , 2019; Ji et al , 2020).…”

Section: Resultsmentioning

confidence: 99%

Dietary whole Goji berry (Lycium barbarum) intake improves colonic barrier function by altering gut microbiota composition in mice

Tian

Zhang

Zhao

et al. 2020

Int J of Food Sci Tech

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Diet strongly affects human health by modulating gut microbiota (GM) composition. Lycium barbarum (LB), which contains polysaccharides and polyphenols, can alter the GM and intestinal barrier function, thereby reducing and preventing the occurrence of intestinal diseases. To investigate how LB improves colonic barrier function, male C57BL/6J mice were fed diets containing 1.5% or 3% LB for 10 weeks. Results of HiSeq 16S rDNA analysis showed that LB markedly altered microbial profile by supporting the growth of Verrucomicrobia, Bacteroidetes, Bacteroidales_S24-7_group, Anaerotruncus, Coprococcus_1, Ruminococcaceae_UCG-014 and Akkermansia, while suppressing Firmicutes, Helicobacter, Bacteroides and Mucispirillum. LB supported the short-chain fatty acid (SCFA)-producing bacteria, and the SCFA concentrations increased, while the ammonia concentrations and pH values in faeces decreased, thereby increasing the expression of tight junction proteins and mucin, subsequently improving intestinal function and histomorphology. Dietary LB, as a functional dietary component, enhanced colonic barrier function and improved gut health by altering GM composition.

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Section: Resultsmentioning

confidence: 99%

Dietary whole Goji berry (Lycium barbarum) intake improves colonic barrier function by altering gut microbiota composition in mice

Tian

Zhang

Zhao

et al. 2020

Int J of Food Sci Tech

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show abstract

“…In the aforementioned study, they found the level of Verrucomicrobia was increased obviously and it exhibited pro-inflammatory properties in AOM/DSS mice ( 37 ). Similarly, a reduction in the ratio of Firmicutes/Bacteroidetes had an effect on the prevention and treatment of CRC ( 40 ). Therefore, these results demonstrated that BBR partially restored the enteric microbiome community in AOM/DSS mice.…”

Section: Discussionmentioning

confidence: 99%

A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis

Chen

Zhang

et al. 2020

Front. Immunol.

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Berberine (BBR) has been reported that it has effects on inhibiting colorectal cancer (CRC). However, the mechanism of BBR on CRC also remains largely unknown. Herein, we investigated the therapeutic effects of BBR on CRC from the perspective of gut microbiota and metabolic alterations, which can provide a holistic view to understand the effects of BBR on CRC. First, azoxymethane (AOM)/dextran sodium sulfate (DSS) mouse was used as CRC animal model, then the degree of colorectal carcinogenesis in AOM/DSS mice with or without BBR administration was measured. The composition and abundance of gut microbiota was investigated by using 16S rRNA. Meanwhile, feces samples were analyzed with 1 H NMR spectroscopy to investigate the metabolic alterations. As a result, BBR significantly reduced intestinal tumor development with lower macroscopic polyps and ki-67 expression of intestinal tissue, and better colonic morphology in mice. Moreover, BBR altered the composition of gut microbiota in AOM/DSS mice obviously, which were characterized by a decrease of Actinobacteria and Verrucomicrobia significantly at the phylum level. At the genus level, it was able to suppress pathogenic species, such as f_Erysipelotrichaceae, Alistipes, and elevate some short-chain fatty acids (SCFA)-producing bacteria, including Alloprevotella, Flavonifractor, and Oscillibacter. Metabolic data further revealed that BBR induced metabolic changes in feces focus on regulating glycometabolism, SCFA metabolism and amino acid metabolism, which also provides evidence for alteration of the microbiota because these feces metabolites are the products of interactions between the host and the microbial community. This study showed that BBR induced alterations in microbiota and metabolic in AOM/DSS mice, which might providing new insight into the inhibition effects of BBR on CRC.

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“…Bacteroides are important members of human intestinal microorganisms that bring countless benets to the host, devoting more than 20% of their genomes to transport and degrade polysaccharides. 58,59 Lactobacillus is a member of lactic acid-producing microorganisms that promote health. 60 Bidobacterium can generate butyrate, which provides an anti-inammatory effect.…”

Section: Diversity Of Gut Microbiota In Lps-induced Inammatory Micementioning

confidence: 99%

Anti-inflammatory activity of a water-soluble polysaccharide from the roots of purple sweet potato

et al. 2020

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Metagenomic analysis of gut microbiota modulatory effects of jujube (Ziziphus jujuba Mill.) polysaccharides in a colorectal cancer mouse model

Abstract: Accumulating evidence has reported that the gut microbiota could play important roles in the occurrence and progression of colorectal cancer.

Cited by 248 publications

References 49 publications

Dietary whole Goji berry (Lycium barbarum) intake improves colonic barrier function by altering gut microbiota composition in mice

Dietary whole Goji berry (Lycium barbarum) intake improves colonic barrier function by altering gut microbiota composition in mice

A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis

Anti-inflammatory activity of a water-soluble polysaccharide from the roots of purple sweet potato

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