Metagenomic analysis of taxonomic and functional changes in gut microbiota of patients with alcoholic dependence syndrome

Dubinkina, Veronika; Tyakht, Alexander; Ilina, Elena N.; Ischenko, Dimitry D; Kovarsky, Boris A.; Yarygin, Konstantin; Pavlenko, Alexander V.; Popenko, Anna; Alexeev, Dmitry; Тараскина, А. Е.; Насырова, Р. Ф.; Krupitski, E. M.; Skorodumova, Liubov O.; Larin, Andrei K.; Kostryukova, Elena S.; Govorun, Vadim M.

doi:10.18097/pbmc20156106742

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…In humans, lower levels of A. muciniphila have also been found in patients with inflammatory digestive diseases and ALDs, especially those induced by an excessive ethanol consumption, whether in the gut [ 110,111 ] or in the blood of patients with cirrhosis. [ 112 ] Lang et al [ 113 ] also demonstrated higher changes in the gut bacterial microbiome of patients with hepatitis due to ALD, proportional to the severity of the disease that were correlated with a significant decrease of A. muciniphila .…”

Section: Resultsmentioning

confidence: 99%

“…[105] The authors suggested that Akkermansia was able to regulate immune system functions through the production of short-chain fatty acids (SCFAs) by metabolizing the complex glycans as a carbon source such as those provided by the mucus layer like N-acetylglucosamine and Nacetylgalactosamine [20,106] or arabinoxylans and inulin, [107][108][109] reducing then the systemic inflammation. [105] In humans, lower levels of A. muciniphila have also been found in patients with inflammatory digestive diseases and ALDs, especially those induced by an excessive ethanol consumption, whether in the gut [110,111] or in the blood of patients with cirrhosis. [112] Lang et al [113] also demonstrated higher changes in the gut bacterial microbiome of patients with hepatitis due to ALD, proportional to the severity of the disease that were correlated with a significant decrease of A. muciniphila.…”

Section: Influence Of Ethanol On a Muciniphilamentioning

confidence: 99%

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Akkermansia muciniphila and Alcohol‐Related Liver Diseases. A Systematic Review

Sparfel,

Ratodiarivony,

Boutet‐Robinet

et al. 2023

Molecular Nutrition Food Res

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ScopeAkkermansia muciniphila (A. muciniphila) are Gram negative commensal bacteria, degrading mucin in the intestinal mucosa, modulating intestinal permeability and inflammation in the digestive tract, liver, and blood. Some components can promote the relative abundance of A. muciniphila in the gut microbiota, but lower levels of A. muciniphila are more commonly found in people with obesity, diabetes, metabolic syndromes, or inflammatory digestive diseases. Over‐intake of ethanol can also induce a decrease of A. muciniphila, associated with dysregulation of microbial metabolite production, impaired intestinal permeability, induction of chronic inflammation, and production of cytokines.Methods and resultsUsing a PRISMA search strategy, a review is performed on the bacteriological characteristics of A. muciniphila, the factors capable of modulating its relative abundance in the digestive tract and its probiotic use in alcohol‐related liver diseases (alcoholic hepatitis, cirrhosis, hepatocellular carcinoma, hepatic transplantation, partial hepatectomy).ConclusionSeveral studies have shown that supplementation with A. muciniphila can improve ethanol‐related hepatic pathologies, and highlight the interest in using this bacterial species as a probiotic.

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Section: Resultsmentioning

confidence: 99%

Section: Influence Of Ethanol On a Muciniphilamentioning

confidence: 99%

Akkermansia muciniphila and Alcohol‐Related Liver Diseases. A Systematic Review

Sparfel,

Ratodiarivony,

Boutet‐Robinet

et al. 2023

Molecular Nutrition Food Res

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“…properties (Bjorkhaug et al, 2019;Jiao et al, 2022). AUD patients showed a consistent proinflammatory profile (Dubinkina et al, 2015).…”

Section: Exploring the Gut Microbiome In Alcohol Use Disorder Excludi...mentioning

confidence: 92%

Commentary on the gut microbiome in alcohol use disorder and alcohol‐associated liver disease

Llorente

2024

Alcohol, Clinical and Experimental Research

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This commentary discusses the systematic review by Erica N. Grodin et al., which examines the gut microbiome's role in alcohol use disorder (AUD) and alcohol-associated liver disease (AALD) (Grodin et al., 2024). The review highlights consistent findings of gut dysbiosis in individuals with AUD and AALD and explores potential gut microbial interventions. Many of the studies analyzed have a predominantly cross-sectional nature. Importantly, the review identifies significant gaps, such as the need for research on sex differences.

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“…Human and/or experimental research demonstrates that the risk of microbial dysbiosis is increased by acute and cumulative psychological and physical (e.g., thermal, noise) stress [275,276,277,278,279,280,281], environmental pollutants including lead, polycyclic aromatic hydrocarbons and airborne particulate matter [282,283,284], tobacco exposure [285,286,287] and excess alcohol consumption [288]. In addition, the oral periodontopathogen P. gingivalis , reported to be much higher in North American disadvantaged populations [289] has recently been shown to cause dysbiosis when swallowed [290].…”

Section: Hygiene Hypothesis Dysbiotic Driftmentioning

confidence: 99%

Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

Prescott

Logan²

2016

IJERPH

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The influential scientist Rene J. Dubos (1901–1982) conducted groundbreaking studies concerning early-life environmental exposures (e.g., diet, social interactions, commensal microbiota, housing conditions) and adult disease. However, Dubos looked beyond the scientific focus on disease, arguing that “mere survival is not enough”. He defined mental health as fulfilling human potential, and expressed concerns about urbanization occurring in tandem with disappearing access to natural environments (and elements found within them); thus modernity could interfere with health via “missing exposures”. With the advantage of emerging research involving green space, the microbiome, biodiversity and positive psychology, we discuss ecological justice in the dysbiosphere and the forces—financial inequity, voids in public policy, marketing and otherwise—that interfere with the fundamental rights of children to thrive in a healthy urban ecosystem and learn respect for the natural environment. We emphasize health within the developmental origins of health and disease (DOHaD) rubric and suggest that greater focus on positive exposures might uncover mechanisms of resiliency that contribute to maximizing human potential. We will entrain our perspective to socioeconomic disadvantage in developed nations and what we have described as “grey space”; this is a mental as much as a physical environment, a space that serves to insidiously reinforce unhealthy behavior, compromise positive psychological outlook and, ultimately, trans-generational health. It is a dwelling place that cannot be fixed with encephalobiotics or the drug-class known as psychobiotics.

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Metagenomic analysis of taxonomic and functional changes in gut microbiota of patients with alcoholic dependence syndrome

Cited by 5 publications

References 30 publications

Akkermansia muciniphila and Alcohol‐Related Liver Diseases. A Systematic Review

Akkermansia muciniphila and Alcohol‐Related Liver Diseases. A Systematic Review

Commentary on the gut microbiome in alcohol use disorder and alcohol‐associated liver disease

Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

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