Metal‐based nanoparticle interactions with the nervous system: the challenge of brain entry and the risk of retention in the organism

Yokel, Robert A.; Grulke, Eric A.; MacPhail, Robert C.

doi:10.1002/wnan.1202

Cited by 38 publications

(33 citation statements)

References 185 publications

(190 reference statements)

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“…We believe this explains the higher gold concentration measured in rat brain at earlier time points in our study, when compared to mouse brain. Blood within tissue samples is known to contribute to the nanoparticle content of the tissue (Yokel, Grulke, and MacPhail 2013). Since no attempts were made to remove the blood from tissues before gold measurements, and since the overall concentration of gold in brain was very low, it is possible that higher blood concentrations of gold in rats influenced the measurements in brain.…”

Section: Discussionmentioning

confidence: 99%

Gold Nanoparticle Toxicity in Mice and Rats: Species Differences

et al. 2018

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Nanotoxicity studies are greatly needed to advance nanomedical technologies into clinical practice. We assessed the toxic effects of a single intravenous exposure to commercially available gold nanoparticles (GNPs) in mice and rats. Fifteen-nm GNPs were purchased and independently characterized. Animals were exposed to either 1,000 mg GNPs/kg body weight (GNP group) or phosphate-buffered saline. Subsets of animals were euthanized and samples collected at 1, 7, 14, 21, and 28 days postexposure. Independent characterization demonstrated that the physicochemical properties of the purchased GNPs were in good agreement with the information provided by the supplier. Mice exposed to GNPs developed granulomas in the liver and transiently increased serum levels of the pro-inflammatory cytokine interleukin-18. No such alterations were found in rats. While there was no fatality in mice post-GNP exposure, a number of the rats died within hours of GNP administration. Differences in GNP biodistribution and excretion were also detected between the two species, with rats having a higher relative accumulation of GNPs in spleen and greater fecal excretion. In conclusion, GNPs have the ability to incite a robust macrophage response in mice, and there are important species-specific differences in their biodistribution, excretion, and potential for toxicity.

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Section: Discussionmentioning

confidence: 99%

Gold Nanoparticle Toxicity in Mice and Rats: Species Differences

et al. 2018

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“…24,[30][31][32][33][34][35][36][37][38] This modification exerted only a limited impact on the biokinetics of PAA-PEG and PAA NPs since most of these NPs in the brain were in residual blood. However, in contrast, the amounts of gold and TiO 2 NPs in the brain cannot be explained by differences in the content of residual blood, which lends support to a permeability greater than zero.…”

mentioning

confidence: 99%

Toward a general physiologically-based pharmacokinetic model for intravenously injected nanoparticles

Carlander

Jolliet

et al. 2016

IJN

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To assess the potential toxicity of nanoparticles (NPs), information concerning their uptake and disposition (biokinetics) is essential. Experience with industrial chemicals and pharmaceutical drugs reveals that biokinetics can be described and predicted accurately by physiologically-based pharmacokinetic (PBPK) modeling. The nano PBPK models developed to date all concern a single type of NP. Our aim here was to extend a recent model for pegylated polyacrylamide NP in order to develop a more general PBPK model for nondegradable NPs injected intravenously into rats. The same model and physiological parameters were applied to pegylated polyacrylamide, uncoated polyacrylamide, gold, and titanium dioxide NPs, whereas NP-specific parameters were chosen on the basis of the best fit to the experimental time-courses of NP accumulation in various tissues. Our model describes the biokinetic behavior of all four types of NPs adequately, despite extensive differences in this behavior as well as in their physicochemical properties. In addition, this simulation demonstrated that the dose exerts a profound impact on the biokinetics, since saturation of the phagocytic cells at higher doses becomes a major limiting step. The fitted model parameters that were most dependent on NP type included the blood:tissue coefficients of permeability and the rate constant for phagocytic uptake. Since only four types of NPs with several differences in characteristics (dose, size, charge, shape, and surface properties) were used, the relationship between these characteristics and the NPdependent model parameters could not be elucidated and more experimental data are required in this context. In this connection, intravenous biodistribution studies with associated PBPK analyses would provide the most insight.

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“…For example, TiO 2 NPs functionalized with dihydrophenylacetic acid can form amide bonds with biomolecules through EDC/NHS chemistry. Thus, this conjugate can be hybridized with antibodies to be employed in targeted photoactivated cytotoxicity applications for A172 and U87 brain cancer cell lines (Yokel et al, 2013). It has been proven that dopamine can also be a valid generic linker that can functionalize the surface of TiO 2 NPs with amines (Manera et al, 2013).…”

Section: Titanium Dioxidementioning

confidence: 99%

Hybrid nanomaterial: biocolloidals

Gözübenli¹,

Yasun²,

Dilsiz³

2017

Turk J Biol

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Nanomaterials-based diagnostics have tremendous advantages over other conventional diagnostic systems in terms of sensitivity, specificity, and portability owing to the unique intrinsic properties of nanomaterials. Thus, there is a substantial need to develop and employ a broad spectrum of nanomaterials for biological and diagnostic applications. In this review, we focus on nanomaterials-assisted disease diagnosis utilizing different techniques such as photoluminescence, colorimetry, fluorescence, electrochemistry, microarray methods, surface plasmon resonance, and surface-enhanced Raman spectroscopy. In these techniques, different nanomaterials, including but not limited to gold and silver materials, metal oxides, and semiconductors, were employed according to their all-purpose chemical and physical properties. As the new properties of nanomaterials are discovered, their contributions to nanobiotechnology applications are vastly increased. In this review, the features of the selected nanobiomaterials, biological tag-modified nanomaterials, and their outstanding applications for the detection of specific biotargets have been summarized according to the latest studies. Nanomaterials contribute to the fields of photo/chemotherapy and biomedical imaging in particular, since all the biological events happen within this size range and beneficiary roles of nanoparticles (NPs) are countless in biomedical applications due to their unique physical and chemical properties. However, due to the necessity of specificity and selectivity, there is a clear ambition to study bioconjugation of NPs to increase the efficiency of the targeted biological applications. Thus, the combination of the specificity and the intrinsic properties of biohybrid NPs facilitate diagnostic and therapeutic applications.

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Metal‐based nanoparticle interactions with the nervous system: the challenge of brain entry and the risk of retention in the organism

Cited by 38 publications

References 185 publications

Gold Nanoparticle Toxicity in Mice and Rats: Species Differences

Gold Nanoparticle Toxicity in Mice and Rats: Species Differences

Toward a general physiologically-based pharmacokinetic model for intravenously injected nanoparticles

Hybrid nanomaterial: biocolloidals

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