Metal Bioaccumulation, Cytogenetic and Clinico-Biochemical Alterations in Rattus norvegicus Exposed In Situ to a Municipal Solid Waste Landfill in Lagos, Nigeria

Gbadebo, Adeyinka M.; Alabi, Okunola A.; Alimba, Chibuisi G.; Bakare, Adekunle A.

doi:10.1007/s12011-021-02758-3

Cited by 9 publications

(8 citation statements)

References 65 publications

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“…Urea and creatinine increased significantly ( p < 0.05) in arsenic plus chromium-treated broiler chicks compared to the control group in the current study. Earlier reports showed a rise in urea and creatinine in rats ( 48 ) for chromium, ducks ( 49 ), and goats ( 50 ) for arsenic. Urea and creatinine levels could be due to ROS generation, which then causes lipid peroxidation.…”

Section: Discussionmentioning

confidence: 96%

“…The mechanism of podocyte injury could be due to the production of ROS, which is deleterious for podocyte contractile, modulating, and linkage proteins. ROS induces unrepairable damage to podocytes leading to changes in cell integrity, thus affecting the glomerular filtration rate (GFR) and leakage of proteins (47). No lesion was recorded in G1 (Control), G4 (Vit E), and G5 (Bentonite); therefore, they were excluded from this table.…”

Section: Discussionmentioning

confidence: 99%

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Oxidative stress and toxicity produced by arsenic and chromium in broiler chicks and application of vitamin E and bentonite as ameliorating agents

Mashkoor

Al-Saeed²,

Guangbin³

et al. 2023

Front. Vet. Sci.

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The present study investigated the adverse effects of arsenic and chromium in broilers and ascertained the role of vitamin E and bentonite in alleviating their harmful effects. For this purpose, we experimented on 180 one-day-old broiler chickens. The feed was administered to broiler chicks of groups 2, 6, 7, 8, and 9 chromium @ (270 mg.kg−1 BW). Groups 3, 6, 7, 8, and 9 were administered arsenic @ (50 mg.kg−1 BW). Groups 4, 7, and 9 received vitamin E (150 mg.kg−1 BW), and groups 5, 8, and 9 received bentonite (5%), respectively. Group 1 was kept in control. All the broiler chicks treated with chromium and arsenic showed a significant (p < 0.05) decline in erythrocytic parameters on experimental days 21 and 42. Total proteins decreased significantly, while ALT, AST, urea, and creatinine increased significantly (p < 0.05). TAC and CAT decreased significantly (p < 0.05), while TOC and MDA concentrations increased significantly (p < 0.05) in chromium and arsenic-treated groups on experimental days 21 and 42. Pearson correlation analysis revealed a strong positive correlation between TAC and CAT (Pearson correlation value = 0.961; p < 0.001), similarly TOC and MDA positive correlation (Pearson correlation value = 0.920; p < 0.001). However, TAC and CAT showed a negative correlation between TOC and MDA. The intensity of gross and microscopic lesions was more in chromium (270 mg.kg−1) and arsenic (50 mg.kg−1) singly or in combination-treated groups. Thus, broiler chicks treated with chromium plus arsenic exhibited higher gross and microscopic lesion intensity than other treated groups. Fatty degeneration, severe cytoplasmic vacuolar degeneration, and expansion of sinusoidal spaces were the main lesions observed in the liver. Kidneys showed renal epithelial cells necrosis, glomerular shrinkage, and severe cytoplasmic vacuolar degeneration. Co-administration of bentonite along with chromium and arsenic resulted in partial amelioration (group 8) compared to groups 7 and 9, administered arsenic + chromium + vitamin E and arsenic + chromium + vitamin E + bentonite, respectively. It was concluded that arsenic and chromium cause damage not only to haemato-biochemical parameters but also lead to oxidation stress in broilers. Vitamin E and bentonite administration can ameliorate toxicity and oxidative stress produced by arsenic and chromium.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Oxidative stress and toxicity produced by arsenic and chromium in broiler chicks and application of vitamin E and bentonite as ameliorating agents

Mashkoor

Al-Saeed²,

Guangbin³

et al. 2023

Front. Vet. Sci.

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“…This was conducted following the procedure of D'Auria et al 47 and Gbadebo et al 46 . After 24 hours of experimentation, the mice were humanely euthanized by cervical dislocation.…”

Section: Bone Marrow Micronucleus Assaymentioning

confidence: 99%

“…Combining these plant extracts may lead to synergistic or antagonistic interactions, enhancing their therapeutic efficacy against rapidly dividing cancer cells [33][34][35][36] . This was conducted following the procedure of Enenebeaku, et al 45 and Gbadebo et al 46 . Upon the completion of the 8 weeks period of experimentation, aliquot blood was collected by cardiac puncture from the animals into a prelabeled EDTA bottles and plain clinical bottles.…”

Section: Introductionmentioning

confidence: 99%

CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE

Egu,

Sale,

Onoja

et al. 2024

Preprint

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Antitumor chemotherapeutic drugs used in lung cancer management cause many adverse effects like damage to healthy cells and tumor relapse. Chemo-therapeutic agents fails to provide a complete cure due to single drug dose. Hence, new treatment, particularly phytotherapy is needed to reduce the side effects. Herein, the synergistic effect of a polyherbal (Phyllanthus amarus, Euphorbia hirta, and Azadirachta indica) recipe was evaluated to determine its suppressive effects at different doses against benzo(a)pyrene (BaP)-induced lung cancer in albino mice. The phytochemical and safety of the recipe using cytogenetic, heamatology and histology indices were also evaluated. High concentration of phenols (158.27%), flavonoids (36.41%) and low concentration of cardenolides and steroids in the extract were identified. BaP exposure induced elevated lipid peroxidation and decreased antioxidant enzyme activity. Significant increase of WBCs and LYM at 100 and 200 mg/kg were observed. The recipe also demonstrated protective effects on liver and kidney biomarkers, and reduction in micronucleus formation, counteracting potential BaP-induced damage. Severe damage in the BaP-treated group lung tissues were observed but the recipe treated groups exhibited reduced damages. The study highlighted the efficacy of the recipe in preventing lung carcinogenesis, underscoring its potential as a preventive measure with curative and anti-proliferative properties.

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“…Boonmee et al (2018) reported that the concentration of Cd induced 10 types of CAs, including SCG, ISCG, SCB, ISCB, CF, D, F, CG, ISAF and SCD, in F. limnocharis. Gbadebo et al (2022) reported that contamination by Pb, Cd, Cr, Cu, Zn and Fe in underground water significantly induced micronuclei and cytotoxicity in rat bone marrow. Bakare et al (2013) suggested a possible mechanism for heavy metal pollution inducing toxicity via oxidative damage.…”

Section: Assessment Of Chromosome Aberrations In S Nigrovittatamentioning

confidence: 99%

Heavy Metals and Metalloid Effects on Cytogenetics in Frogs (Sylvirana nigrovittata) around the Sepon Gold-Copper Mine, Lao PDR

Ruksachat¹,

Tengjaroensakul²,

Neeratanaphan³

et al. 2023

NLSC

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The objectives of the present study were to determine the concentrations of heavy metals and metalloids in frogs (Sylvirana nigrovittata) and to assess chromosome aberrations (CAs) in frogs collected from the Nam Kok River near the Sepon gold-copper mine, Lao PDR, as compared with those from a reference site. The results showed that the concentrations of As, Cd, Cr, and Mn in the frog muscle samples exceeded the standard values, and the accumulation of heavy metals in the frogs from the two sampling sites was significantly different (P <0.05), particularly Ba, Cd, Cr, Cu, Fe, Mn and Ni. Chromosome assessment of S. nigrovittata from the study site revealed 13 types of CAs, and the highest total number of CAs was isochromatid gap with a percentage of 31.80%. Furthermore, the total number of CAs, cell number with CAs and percentage of CAs in the frogs from both sites were significantly different (P <0.05). The results of this study suggest that heavy metal and metalloid from the Sepon gold-copper mine area negatively affected S. nigrovittata in terms of chromosomal defects. Keywords: Aberration, Abnormality, Amphibian, Animal, Toxicant

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Metal Bioaccumulation, Cytogenetic and Clinico-Biochemical Alterations in Rattus norvegicus Exposed In Situ to a Municipal Solid Waste Landfill in Lagos, Nigeria

Cited by 9 publications

References 65 publications

Oxidative stress and toxicity produced by arsenic and chromium in broiler chicks and application of vitamin E and bentonite as ameliorating agents

Oxidative stress and toxicity produced by arsenic and chromium in broiler chicks and application of vitamin E and bentonite as ameliorating agents

CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE

Heavy Metals and Metalloid Effects on Cytogenetics in Frogs (Sylvirana nigrovittata) around the Sepon Gold-Copper Mine, Lao PDR

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