2021
DOI: 10.1002/ajoc.202100604
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Metal‐Catalyzed Divergent Synthetic Methods for Pyrrolocoumarins and Furocoumarins

Abstract: We describe a divergent synthesis of pyrrolocoumarins and furocoumarins starting from the 4‐(arylethynyl)‐3‐bromocoumarins under metal‐catalyzed conditions. The one‐pot synthesis of pyrrolocoumarins is achieved using 4‐(arylethynyl)‐3‐bromocoumarins under copper‐catalyzed conditions. The synthesis of furocoumarins involved a two‐step protocol from 4‐(arylethynyl)‐3‐bromocoumarins through the formation of 3‐bromo‐4‐(2‐oxo‐2‐arylethyl)coumarins under iron‐catalyzed conditions followed by their copper‐catalyzed c… Show more

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Cited by 3 publications
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“…The synthesis of furocoumarins has been known for a long time. However, novel methodologies have been developed during the last decades for the effective preparation of these compounds, many of which involve metal-catalyzed transformations that provide new structural diversity [ 80 , 81 ].…”
Section: Coumarin Derivatives From Marine World: Synthesis and Activi...mentioning
confidence: 99%
“…The synthesis of furocoumarins has been known for a long time. However, novel methodologies have been developed during the last decades for the effective preparation of these compounds, many of which involve metal-catalyzed transformations that provide new structural diversity [ 80 , 81 ].…”
Section: Coumarin Derivatives From Marine World: Synthesis and Activi...mentioning
confidence: 99%