Metal complexes as artificial proteases: toward catalytic drugs

Recent advances in biosensory and medicinal therapeutic applications of zinc(II) and copper(II) coordination complexes

“…In similar work, Suh and coworkers [128] have made significant progress in the development of both selective and non-selective proteases based on Cu(II) complexes [126]. Notably, this group developed the first artificial protease specific to a target protein, in this particular case myoglobin.…”

“…Providing that reasonable target specificity could be attained, such molecules could represent a new and promising class of molecular therapeutics [126]. Soares and coworkers synthesized and structurally characterized a tripodal Cu(II) complex of 2-[(bis(pyridylmethyl)amino)methyl]-4-methyl-6-formylphenol (HL), 20 (Fig.…”

Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands

“…The IR spectra of ligands 1 and 2 show ν (C=N) and ν (=N-OH) peaks at 1633 and 3404 and at 1603 and 3361 found that the ν (C=N) bands in the complexes are shifted by about 1-41 cm −1 to the higher/lower energy regions compared to the free ligands. 17 A broad phenolic OH peak of free ligands 1 and 2 at about 3100-3200 cm −1 disappears on complexation. This phenomenon appears to be due to the coordination of the azomethine nitrogens and phenolic oxygens to the metal ion.…”

Synthesis and spectroscopic studies of homo-binuclear, alkoxo bridged homo- and hetero-tetranuclear metal complexes of a bis-N2O4 Schiff base ligand derived from ethanolamine and macroacyclic tetranaphthaldehyde

“…The development of the field of bioinorganic chemistry has increased interest in Schiff base complexes since many of these diand tetranuclear complexes may serve as models for biologically important species [11][12][13].…”