Metal Complexes of Biologically Important Ligands, CLXXVI.[1] Formation of Peptides within the Coordination Sphere of Metal Ions and of Classical and Organometallic Complexes and Some Aspects of Prebiotic Chemistry

Abstract

The formation of peptide bonds in the neighborhood of metal ions is reviewed. The metal ions can function as activating and catalytic groups; they can act as templates. Metal ions can play a role as stabilizing spectators when peptides are formed within their ligands and they are able to protect the amino or carboxylate group of amino

Hydration of serine–metal cation complexes: implication for the role of water in the origin of homochirality on the Earth

“…7s) in comparison to the hydration of serine-Ca and serine-Mg complexes. Divalent metal cation could enhance the prebiotic formation of the first peptides from amino acids (Beck 2011;Kitadai et al 2011;Remko and Rode 2004). The differences in the efficiency of hydration of homo and heterochiral metal cation-amino acid complexes undoubtedly led to the amplification of formation of homochiral peptides in water solution from which life emerged.…”

Metal Complexes of Biologically Important Ligands, CLXXVII. Dichlorido Platinum(II) and Palladium(II) Complexes with Long Chain Amino Acids and Amino Acid Amides

“…Following our strategy for peptide synthesis at platinum,, the carboxylic groups of 3 and 4 (activated as esters with N‐hydroxysuccineimide) were reacted with NH 2 (CH 2 ) 17 CH 3 , d ‐glucosamine, and ( R , R )‐1,2‐diaminocyclohexane, using the water soluble N ‐ethyl‐ N ′‐(3‐dimethylaminopropyl)carbodiimide (EDC) as coupling agents, to give the dichlorido platinum complexes 5 – 8 with amino acid amides as ligands. For complex 7 a polymeric structure seems plausible and for complex 8 a dimeric structure is proposed, as it has been formulated for complexes from reactions of cis ‐Cl 2 Pt(glyOH) 2 and cis ‐Cl 2 Pt(glyglyOH) 2 with 1,2‐diaminocyclohexane.…”

“…In our research the Grinberg and Volshtein complexes CL 2 Pt(NH 2 CHRCOOH) 2 have been introduced as amino protecting groups for peptide synthesis, and for the attachment of biologically active compounds such as steroids and aminosaccharides via coordinated amino acid residues to give potentially antitumor active complexes . Also corresponding palladium complexes were used , .…”

Wet degradation of keratin proteins: linking amino acid, elemental and isotopic composition

“…However, these investigations are based on closed‐system kinetics which is likely to be fundamentally different from the open‐system diagenesis of hair. In open systems, the presence of metal ions may additionally catalyse the racemisation, degradation and cross‐linking of AAs in residual proteins and in soluble peptides produced by degradation …”

“…In open systems, the presence of metal ions may additionally catalyse the racemisation, degradation and cross-linking of AAs in residual proteins and in soluble peptides produced by degradation. [19] The measurements of the fibre isotopic composition are therefore expected to be affected by these reactions, for example by:…”