Metal complexes with polyfunctional ligands based of bis(hydrazones) of dicarbonyl compounds

Synthesis, characterization and crystal structures of two pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent. Anticancer properties of various metal complexes of the same ligand

“…The coordination properties of 2,6-diacetylpyridine bis(acylhydrazones) towards 3d metal ions [1][2][3][4][5], some lanthanides [1,[6][7][8], main group [1,[9][10][11], 4d and 5d elements [1] have been intensively studied over the years. The 2,6-diacetylpyridine bis(acylhydrazone) ligands possess at least five donor atoms (N3O2) in spatial arrangement which supports formation of sevencoordinated complexes with pentagonal-bipyramidal (PBPY-7) geometry.…”

“…The 2,6-diacetylpyridine bis(acylhydrazone) ligands possess at least five donor atoms (N3O2) in spatial arrangement which supports formation of sevencoordinated complexes with pentagonal-bipyramidal (PBPY-7) geometry. Pentagonalbipyramidal geometry is the most common, but not exclusive among the reported complexes with 2,6-diacetylpyridine bis(acylhydrazone) ligands, and possibility for its formation depends on the nature of central metal ion, conformational flexibility of hydrazone ligand and reaction conditions [1]. The acidity of hydrazone function in 2,6-diacetylpyridine bis(acylhydrazone) ligands contributes to structural versatility of their complexes due to possibility of coordination of ligand in non-deprotonated, partially deprotonated and fully deprotonated form [12].…”

Bis‐aroylhydrazone based on 2,2′‐bis substituted diphenylamine for synthesis of new binuclear organotin (IV) complexes: Spectroscopic characterization, crystal structures, in vitro DNA‐binding, plasmid DNA cleavage, PCR and cytotoxicity against MCF7 cell line

“…Acyl/arοyl‐hydrazones with the ‐C=NNHC(O)‐ functional group are a particular category of these type of hydrazone compounds, and interest in their use as multifunctional ligands has increased considerably . Among these derivatives, the chemistry of bis acyl/arοyl‐hydrazone compounds is seen to be of particular interest for the following reasons: (a) there is the possibility of creating supermolecular structures and various types of coordination polymers using these ligands; (b) coordination of a metal ion into such a unit may cause changes in the characteristics of the other units; (c) due to the different degree of deprotonation available for these multi‐proton ligands, complexes with various charges can be synthesized . Bis‐acyl/arοyl‐hydrazones can be prepared from the reaction of a dihydrazide and an aldehyde or ketone in a 1:2 ratio, or from a similar reaction of a dialdehyde or diketone with a hydrazide.…”

Synthesis, characterization, DFT calculations and antimicrobial activity of pentagonal-bipyramidal Zn(II) and Cd(II) complexes with 2,6-diacetylpyridine-bis(trimethylammoniumacetohydrazone)

“…Coordination of N 3 O 2 donors allows formation of pentagonal-bipyramidal (PBPY- 7) complexes with resonance stabilized nearly planar system in equatorial plane, consisting of four five-membered chelate rings and monodentate ligands in the apical positions [1,2]. Pentagonalbipyramidal (PBPY-7) geometry is not exclusive for complexes with 2,6-diacetylpyridine acylhydrazones and the extent of its deformation depends on conformational flexibility of ligand molecule, d n configuration of the metal ion and reaction conditions [2][3][4][5][6]. Coordination of 2,6-diacetylpyridine acylhydrazone ligands to Zn(II) may result in formation of both mono [7] and binuclear complexes [8,9].…”