Metal exposure and breast cancer among Northern Mexican women: assessment of genetic susceptibility

Gamboa-Loira, Brenda; Mérida-Ortega, Ángel; Rothenberg, Stephen J.; Cebrián, Mariano E.; López‐Carrillo, Lizbeth

doi:10.1007/s11356-022-21067-3

Cited by 4 publications

(2 citation statements)

References 76 publications

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“…Clinical studies have shown that the high expression of CYP1A1 is correlated with the malignant degree and prognosis of breast cancer. Thus, the inhibition of CYP1A1 may be a potential therapeutic target for the treatment of breast cancer [12]. The NF-κB signaling pathway is closely related to tumor genesis and development.…”

Section: Discussionmentioning

confidence: 99%

“…The CYP family is involved in the metabolism of many carcinogens, producing secondary metabolites, which can lead to DNA damage and chemical admixtures. It can also be used for the activation or inactivation of anticancer drugs [11,12]. CYP1A1, CYP1A2, and CYP2E1 can reveal the association between gene polymorphism and cancer susceptibility, and they are responsible for the biotransformation of chemical substances [13].…”

Section: Introductionmentioning

confidence: 99%

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Tetrahydrocurcumin regulates the tumor immune microenvironment to inhibit breast cancer proliferation and metastasis via the CYP1A1/NF-κB signaling pathway

Zeng

Bao

et al. 2023

Cancer Cell Int

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The NF-κB signaling pathway is overactivated in tumor cells, and the activation of the NF-κB signaling pathway releases a large number of inflammatory factors, which enhance tumor immunosuppression and promote tumor metastasis. The cytochrome P450 (CYP450) system consists of important metabolic enzymes present in different tissues and progressive tumors, which may lead to changes in the pharmacological action of drugs in inflammatory diseases such as tumors. In this study, the anticancer effect of tetrahydrocurcumin (THC), an active metabolite of curcumin, on breast cancer cells and the underlying mechanism were investigated. Result showed that THC selectively inhibited proliferation and triggered apoptosis in breast cancer cells in a concentration- and time-dependent manner. Moreover, THC-induced cell apoptosis via a mitochondria-mediated pathway, as indicated by the upregulated ratio of Bax/Bcl-2 and reactive oxygen species (ROS) induction. In addition, THC could affect the CYP450 enzyme metabolic pathway and inhibit the expression of CYP1A1 and activation of the NF-κB pathway, thereby inhibiting the migration and invasion of breast cancer cells. Furthermore, after overexpression of CYP1A1, the inhibitory effects of THC on the proliferation, metastasis, and induction of apoptosis in breast cancer cells were weakened. The knockdown of CYP1A1 significantly enhanced the inhibitory effect of THC on the proliferation, metastasis, and apoptosis induction of breast cancer cells. Notably, THC exhibited a significant tumor growth inhibition and anti-pulmonary metastasis effect in a tumor mouse model of MCF-7 and 4T1 cells by regulating the tumor immunosuppressive microenvironment. Collectively, these results showed that TH could effectively trigger apoptosis and inhibit the migration of breast cancer cells via the CYP1A1/NF-κB signaling pathway, indicating that THC serves as a potential candidate drug for the treatment of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tetrahydrocurcumin regulates the tumor immune microenvironment to inhibit breast cancer proliferation and metastasis via the CYP1A1/NF-κB signaling pathway

Zeng

Bao

et al. 2023

Cancer Cell Int

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Cohort profile: Guangzhou breast cancer study (GBCS)

Wang,

Li,

Xiao

et al. 2024

Eur J Epidemiol

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The Guangzhou Breast Cancer Study (GBCS) is a patient-based prospective cohort study designed to identify risk factors and underlying mechanisms for breast cancer (BC) incidence and prognosis, specifically addressing the need for individualized prevention in South China, where BC incidence is notably high. Based in Guangzhou, China, the GBCS began recruitment in 2008, comprises three complementary studies: the Guangzhou breast cancer cohort with 5471 breast cancer patients, a case–control study with 1551 cases and 1605 controls, and an immunohistochemistry (IHC) cohort with 1063 breast cancer patients. Participants are primarily aged 41–60 years. Cohort follow-up is conducted every three months in the first year, every six months in the second and third years, and annually thereafter. High follow-up rates have been achieved until 2023, with 73.5% for the Guangzhou breast cancer cohort and 98.6% for the IHC cohort still active. Baseline data collection included demographic characteristics and breast cancer risk factors, while follow-up data included survival, treatment details, disease history, occupational history, post-diagnostic lifestyle, and laboratory measures, including genetic markers, proteins, and environmental exposures. The study encourages global collaborations and invites interested researchers to contact the corresponding author at xulin27@ mail.sysu.edu.cn with specific research ideas or proposals.

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Relationship Between Arsenic in Biological Media and Breast Cancer: A Systematic Review and Meta-Analysis

Nikravesh,

Ghanbari,

Badiee

et al. 2024

Biol Trace Elem Res

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Metal exposure and breast cancer among Northern Mexican women: assessment of genetic susceptibility

Cited by 4 publications

References 76 publications

Tetrahydrocurcumin regulates the tumor immune microenvironment to inhibit breast cancer proliferation and metastasis via the CYP1A1/NF-κB signaling pathway

Tetrahydrocurcumin regulates the tumor immune microenvironment to inhibit breast cancer proliferation and metastasis via the CYP1A1/NF-κB signaling pathway

Cohort profile: Guangzhou breast cancer study (GBCS)

Relationship Between Arsenic in Biological Media and Breast Cancer: A Systematic Review and Meta-Analysis

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