Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)–C(Alkyl) bond cleavage for quinolone scaffold synthesis

Abstract

An unexpected iodine(III)-mediated C(sp3)-C(sp2) bond cleavage of 3-(methylamino)-2-(2-substitutedbenzoyl)acrylates for efficient synthesis of privileged scaffold 4-quinolones was described. Notably, a wide range of alkyl groups (e.g. methyl, tert-butyl or alkyl chain)...

Electrochemical cascade migratory versus ortho-cyclization of 2-alkynylbenzenesulfonamides

“…Though both the ortho -addition and ipso -addition can lead to net ortho -cyclization products, there only exist very limited studies on the selective formation of migratory cyclization products. 8 …”