Metal‐Free Oxidative Cross‐Dehydrogenative Coupling of Alkenes with Thiophenols

Abstract

A novel transition‐metal‐free regioselective allylic C−H thiolation of alkenes has been achieved by cross‐dehydrogenative coupling strategy. The present protocol realizes efficient and highly regio‐ and stereo‐selective functionalization of allylic C−H bonds under metal‐free conditions, leading to a series of allylic thioethers in good to excellent yields. Moreover, this work features mild reaction conditions, high step‐ and atom‐economy and good functional group tolerance.

Low-Valent-Tungsten-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling Reaction

“…Moreover, Song's group revealed that the transition metal tungsten catalytic system could realize the oxidative dehydrogenative coupling of anilines for the synthesis of azoaromatics and azoxyaromatics [34]. Herein, considering the significance of organosulfur molecules and our continuous interest in aerobic cross-dehydrogenative coupling reactions for the construction of organosulfur compounds [35,36], we disclosed a tungsten-catalyzed aerobic oxidative cross-dehydrogenative coupling of thiols and phosphonates or indoles for the facile synthesis of organosulfur derivatives after exerting tremendous efforts.…”