Metal-ion Assisted, Radiation-induced Conversion of B- to Z-DNA in Poly (dGdC) and Two Natural DNAs

Trumbore, Conrad N.; Myers, Y N; Hyde, Chris; Hudson, R. D.; Rhodes, C N; Masselink, J K

doi:10.1080/09553009414551491

Cited by 15 publications

(3 citation statements)

References 4 publications

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“…The smaller metal ion concentration could induce this conversion in DNA with strand breaks than in the absence of strand breaks. It is attributed to the reduction in the high activation energy barrier in the metal ion driven B-DNA to Z-DNA conformation [194]. It also provides a clue as to why severely affected AD-DNA could go to Z-form from B-form, probably due to DNA fragmentation and this may be assisted by metals like Zn, Cu, Fe, and Al, which are elevated in the AD brain [195].…”

Section: Dna Structural Changes In Admentioning

confidence: 98%

Genotoxicity in Alzheimers Disease: Role of Amyloid

Anitha

Venugopal²,

Prakasam³

et al. 2006

CAR

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Alzheimer's disease (AD) is a complex neurodegenerative disorder pathologically identified by the presence of extracellular senile plaques (SP) with a proteinaceous core composed of aggregates of the amyloid peptide (Abeta) and intracellular aggregates of the microtubule-associated protein tau (tau) as neurofibrillary tangles (NFTs). These hallmarks consist of abnormally folded proteinaceous components that are believed to be neurotoxic in AD. The mechanisms of toxicity remain unclear although oxidative stress and inflammation are implicated as mediators of the toxicity and these lesions, in turn, are known to damage cellular components including proteins, lipids in the membrane and DNA. However effects on genotoxicity and its role in AD are less clear. The present review discusses various influences, in particular of amyloid, on the genetic material and their possible role in the neurodegeneration in AD. Further, the amalgamation of genomics and proteomics in understanding AD and therapeutic development is suggested.

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Section: Dna Structural Changes In Admentioning

confidence: 98%

Genotoxicity in Alzheimers Disease: Role of Amyloid

Anitha

Venugopal²,

Prakasam³

et al. 2006

CAR

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“…Because of the closer distance among phosphate groups and deeper and narrower minor grooves, more repulsion and steric hindrance generated, thus the Z-form is always in an transient and high energy state that is required to be stabilized by extrinsic factors, such as high ionic concentration [11][12][13], base chemical modification [14][15][16][17][18][19] or certain organic solvents [20,21]. In the aspect of ionic strength, high ion strength could induce and stabilize Z-DNA, including monovalent cation such as 2.5M NaCl, K + , Li + and some divalent 700mM MgCl 2 , 100mM CaCl 2 , 40mM BaCl 2 , Mn 2+ or certain concentration of Ni 2+ together with Na + or Mg 2+ [22][23][24][25].…”

Section: B To Z Transitionmentioning

confidence: 99%

Advancements in Z-DNA: Development of Inducers and Stabilizers for B to Z Transition

Yang¹,

Wang²,

Tian³

et al. 2012

CMC

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Z-DNA, an active element in genome, has drawn intense interest in chemical and biological field. Its dynamic and transient state makes it challenging to target and regulate. Thus, stabilizing and inducing Z-DNA both in vitro and in vivo is essential, so far, much many efforts have been made in these aspects. However, Z-DNA's induction and stabilization are always performed in high salt condition and sequence-dependent, limited inducers or stabilizers have been achieved with breakthrough in the aspects of real physiological condition and sequence-independence. Herein, we give a review of some typical kinds of Z-DNA inducers and stabilizers, discussing their inducing or stabilizing condition, mechanism, structural relationship and their limitation as well, attempted to get some implication and guidance for Z-DNA inducer or stabilizer design.

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“…It is attributed to the reduction in the high activation energy barrier in the metal ion driven B→Z conformation [42]. Studies have shown that radiation induced DNA damage i.e.…”

Section: Ii] Altered Dna Topologymentioning

confidence: 99%

Role of Protein Conformational Dynamics and DNA Integrity in Relevance to Neuronal Cell Death in Neurodegeneration

Gupta

Hegde²,

Rao

2006

CAR

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Apoptosis has been implicated in the pathogenesis of various neurodegenerative disorders, although the extent to which it is responsible for the neurodegeneration along with other kind of cell death events is not known. Eventhough much information is available today on the apoptotic cascades in general, the precise mechanism and the exact sequence of events leading to neuronal degeneration in Alzheimer's disease (AD) and other neurodegenerative disorders is not understood till now. Amyloid beta (Abeta) proteins are the hallmark toxic proteins known to cause the activation of apoptotic cascades via caspase dependent and caspase-independent pathways. Abeta can cause neuronal apoptosis through multiple mechanisms involving mitochondria and endoplasmic reticulum as the key organelles. In this review, we have discussed the role of apoptosis in neurodegeneration and provided new thoughts on the role of protein conformational dynamics and DNA integrity associated with neurodegenerative disorders. An insight on whether the apoptosis observed in the neurodegenerative disorders is of any functional advantage has been discussed.

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Metal-ion Assisted, Radiation-induced Conversion of B- to Z-DNA in Poly (dGdC) and Two Natural DNAs

Cited by 15 publications

References 4 publications

Genotoxicity in Alzheimers Disease: Role of Amyloid

Genotoxicity in Alzheimers Disease: Role of Amyloid

Advancements in Z-DNA: Development of Inducers and Stabilizers for B to Z Transition

Role of Protein Conformational Dynamics and DNA Integrity in Relevance to Neuronal Cell Death in Neurodegeneration

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