Metal ions modulation of the self-assembly of short peptide conjugated nonsteroidal anti-inflammatory drugs (NSAIDs)

Fu, Wenjiao; Sabet, Zeinab Farhadi; Liu, Jiaming; You, Min; Zhou, Huige; Wang, Yaling; Gao, Yuan; Li, Jiayang; Ma, Xiaomin; Chen, Chunying

doi:10.1039/d0nr00572j

Cited by 19 publications

(17 citation statements)

References 50 publications

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“…As essential components in living organisms, metal ions can also be used to modulate natural biomolecules, such as proteins, 220 peptide derivatives, [221][222][223][224][225] and nucleic acids. In 2020, Chen and co-workers 226 developed a novel hydrogel system, in which therapeutic peptide derivatives were F I G U R E 9 (A) (i) Schematic cell modulating platform. The RGD-grafting magnetic Fe 3 O 4 nanoparticles exhibit exposed or hidden state under upward or downward magnetic field triggering the activation or inactivation of cell adhesion, (ii) chemical structures of RGD-grafting magnetic Fe 3 O 4 nanoparticles modified on methacrylate hyaluronic acid.…”

Section: Ion-responsive Hydrogelmentioning

confidence: 99%

“…Reproduced with permission. 226 Copyright 2020, The Royal Society of Chemistry. (B) (i) DNA hydrogel constructed by Ag + -stabilized Y-shape DNA subunits and its reversible formation and dissociation, (ii) DNA hydrogel constructed by acrylamide-acrydite nucleic acid copolymer where the polymer chains were crosslinked by cytosine-Ag + -cytosine complexes.…”

Section: Multistimuli-responsive Hydrogelmentioning

confidence: 99%

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Stimuli‐responsive hydrogels: Fabrication and biomedical applications

Zhou

et al. 2021

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Due to their similarity to some bio-architectures, for example, extracellular matrix, hydrogels are considered as bio-inspired networks with bio-mimetic and bio-functional properties. With natural cytocompatibility and biocompatibility, hydrogels nowadays are more and more involved in various bioapplications including shape morphing, artificial muscles, soft robotics, regenerative medicine, and so on. As an important subclass, stimuli-responsive hydrogels have been attracting interest within decades. In response to single or multi-triggers in biological microenvironment, stimuli-responsive hydrogels can undergo phase transition, stiffness change, or biochemical properties activation, which make them intriguing biomaterials with broad applications including sensing, drug delivery, tissue engineering, and wound healing. This review presents typical synthetic and natural gelators comprising small molecules and polymers as building blocks of functional architectures. The fabrication strategies of hydrogels varied from supramolecular assembly to dynamic covalent binding are detailed. Various exogenous or endogenous, physical or chemical, and synthetic or natural stimuli together with response mechanism, design principle are demonstrated. Through recent examples from different perspectives, such as bionic devices, wound dressing, and cargo carrier, the benefits and opportunities of stimuli-responsive hydrogels for biological applications are highlighted. Finally, the current challenges and future prospects in view of translation from fundamental researches to clinical application are briefly discussed.

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Section: Ion-responsive Hydrogelmentioning

confidence: 99%

Section: Multistimuli-responsive Hydrogelmentioning

confidence: 99%

Stimuli‐responsive hydrogels: Fabrication and biomedical applications

Zhou

et al. 2021

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144

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“…It indicated that BPE was more readily to form aggregates in water [14] . The strong aggregation ability and π–π stacking between BPE molecules may influence the interaction between water and H e , which finally contributing the formation of right‐handed helices [15] . Compared with H 2 and H 3 , the H 1 of BPE with lower electropositivity has no ability to form hydrogen bonding.…”

Section: Figurementioning

confidence: 99%

Co‐assembled Supramolecular Gel of Dipeptide and Pyridine Derivatives with Controlled Chirality

Guo

et al. 2020

Angew Chem Int Ed

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It is commonly considered that amyloid-b (Ab) fibrils are heavily involved in the neurological diseases. Establishing an external model based on the core recognition motif (diphenylalanine, FF) of Ab would be of significance in understanding the assembly and disassembly of Ab fibrils in living system. Herein, supramolecular gels with structure transition from amyloid-like b-sheet to different supramolecular helices were obtained through the co-assembly of a Nfluorenylmethoxycarbonyl-protected L-FF (L-FmocFF) with achiral pyridine derivatives. It is found that the different stacking modes (H-or J-aggregates) of additives and the microenvironment of chiral carbon play vital roles for the selectively chiral transfer or amplification of L-FmocFF. The dynamic process of helix formation was also captured. This work provides a convenient co-assembly way to explore the structure basis of Ab fibrils with a controlled chirality.

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“…[14] The strong aggregation ability and p-p stacking between BPE molecules may influence the interaction between water and H e , which finally contributing the formation of right-handed helices. [15] Compared with H 2 and H 3 , the H 1 of BPE with lower electropositivity has no ability to form hydrogen bonding. Therefore, the H 2 and H 3 displayed significant upfield shift with the increase of temperature while no obvious chemical shift of H 1 was exhibited (Figure 4 f).…”

Section: Angewandte Chemiementioning

confidence: 99%

Co‐assembled Supramolecular Gel of Dipeptide and Pyridine Derivatives with Controlled Chirality

Guo

et al. 2020

Angewandte Chemie

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Metal ions modulation of the self-assembly of short peptide conjugated nonsteroidal anti-inflammatory drugs (NSAIDs)

Abstract: Naproxen-FF shows superb responsiveness to multiple metal ions and its assembly capacity is obviously improved due to its methoxy group.

Cited by 19 publications

References 50 publications

Stimuli‐responsive hydrogels: Fabrication and biomedical applications

Stimuli‐responsive hydrogels: Fabrication and biomedical applications

Co‐assembled Supramolecular Gel of Dipeptide and Pyridine Derivatives with Controlled Chirality

Co‐assembled Supramolecular Gel of Dipeptide and Pyridine Derivatives with Controlled Chirality

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