No abstract

Carbonic anhydrase (CA) IX overexpresses exclusively on cell membranes of hypoxic tumors, regulating the acidic tumor microenvironment. Small molecules of CA inhibitor modified with short peptide successfully achieve CA IX–targeted self-assembly that localizes CA inhibitors on hypoxic cancer cell surfaces and enhances their inhibition efficacy and selectivity. CA IX–related endocytosis also promotes selective intracellular uptake of these nanofibers under hypoxia, in which nanofiber structures increase in size with decreasing pH. This effect subsequently causes intracellular acid vesicle damage and blocks protective autophagy. The versatility of tunable nanostructures responding to cell milieu impressively provokes selective toxicities and provides strategic therapy for hypoxic tumors. Moreover, in vivo tests demonstrate considerable antimetastatic and antiangiogenesis effects in breast tumors, and particularly remarkable enhancement of antitumor efficacy in doxorubicin administration. With its biocompatible components and distinctive hypoxia therapies, this nanomaterial advances current chemotherapy, providing a new direction for hypoxic cancer therapy.

Naproxen-FF shows superb responsiveness to multiple metal ions and its assembly capacity is obviously improved due to its methoxy group.

The database was created through clinical data collection, and the rules of acupoint compatibility of filiform needle acupuncture in the treatment of Xiang Bi disease were studied by association rules. The acupuncture points of needle were extracted from the database, and the Apriori algorithm in SPSS modeler 18.0 was used to analyze the association rules of acupuncture points. Sixty nine acupoints were used in treating Xiang Bi disease with filiform acupuncture, among which 19 acupoints were used more than 10 times. The results of association rules showed that there were 17 groups of compatibility combinations to support above 10% and confidence above 80%, mainly with local acupoints and far and near acupoints. It is feasible to study the compatibility law of acupuncture treatment of Xiang Bi disease based on association rules, and the research results can serve as a basis for clinical practice.