“…Electrochemiluminescence (ECL) is a powerful and promising analytical technique based on the light-emitting chemical reactions at the electrode surface triggered by external potentials . The ECL technology has attracted great interest of multidisciplinary researchers because it possesses unique superiorities including near-zero background, strong controllability, wide dynamic range, remarkable versatility, etc. , Gold nanoclusters (AuNCs) are appealing with excellent biocompatibility, unique optoelectronic properties, and high recognition reactivity, which have gradually become a promising emerging family of ECL emitters . In recent years, ECL sensors based on AuNCs have been introduced and widely used for biological detection. , To date, various AuNC-based ECL-sensing platforms with distinct mechanisms have been evidenced, such as ECL resonance energy transfer (ECL-RET), , co-reaction catalysis, protein hydrogel-based antibiofouling sensing strategy, and aggregation-induced ECL .…”