Metal nanoparticles: biomedical applications and their molecular mechanisms of toxicity

Malik, Ajamaluddin; Khan, Javed Masood; Alhomida, Abdullah S.; Ola, Mohammad Shamsul; Alshehri, Mohammed Abdulkarim; Ahmad, Aqeel

doi:10.1007/s11696-022-02351-5

Cited by 16 publications

(5 citation statements)

References 355 publications

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“…During the present nanotechnological area, metallic or metal oxides nanoparticles find extensive application in different areas, from advanced sensors [8] to environmental protection [9,10], and from the biomedical area [11] to day-by-day products [12,13]. As their wide range of application grew, so did the various concerns regarding their potential detrimental effects on the environment and human health [14].…”

Section: Introductionmentioning

confidence: 99%

Phytosynthesis of Silver Nanoparticles Using Leonurus cardiaca L. Extracts

et al. 2023

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The present work describes, for the first time in the literature, the phytosynthesis of silver nanoparticles using Leonurus cardiaca L. extracts. The influence of the extraction method (classical temperature extraction and microwave extraction), as well as of the extract concentration on the characteristics of the nanoparticles, was studied using analytical methods, such as UV-Vis spectrometry, X-ray diffraction, dynamic light scattering, and transmission electron microscopy. Experimental data suggest that use of lower extract concentration leads to smaller dimensions nanoparticles, the same effect using the extract obtained by microwave-assisted extraction. The smallest recorded crystallite sizes (by X-ray diffraction) were under 3 nm. The antioxidant properties (determined by the DPPH assay) and the antimicrobial potential (determined against Gram-negative and Gram-positive strains) are enhanced by the phytosynthesis process (as demonstrated by the comparison of the nanoparticles’ properties with the parent extracts). The present work could also represent an important step in obtaining nanoparticles with enhanced properties and controlled morphologies, but also offers information on the phytosynthesis of metallic nanoparticles using low extract concentrations.

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Section: Introductionmentioning

confidence: 99%

Phytosynthesis of Silver Nanoparticles Using Leonurus cardiaca L. Extracts

et al. 2023

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“…Nanoparticles require specialized coatings for treatment of specific organs and infections. Metal nanoparticles are likely toxic to bacteria through their generation of reactive oxygen species; , while this mechanism is less amenable to evasion by bacteria, metal nanoparticles also can potentially be toxic to normal cells and to cells upon emission into the environment. Antibacterial films (if used internally), implants, and composites are mechanically stable, but the release of coatings or fragments from films or implants may lead to undesired toxicity.…”

Section: Antibioticsmentioning

confidence: 99%

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

Ralhan,

Iyer,

Diaz

et al. 2024

ACS Infect. Dis.

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The development of effective antibacterial solutions has become paramount in maintaining global health in this era of increasing bacterial threats and rampant antibiotic resistance. Traditional antibiotics have played a significant role in combating bacterial infections throughout history. However, the emergence of novel resistant strains necessitates constant innovation in antibacterial research. We have analyzed the data on antibacterials from the CAS Content Collection, the largest human-curated collection of published scientific knowledge, which has proven valuable for quantitative analysis of global scientific knowledge. Our analysis focuses on mining the CAS Content Collection data for recent publications (since 2012). This article aims to explore the intricate landscape of antibacterial research while reviewing the advancement from traditional antibiotics to novel and emerging antibacterial strategies. By delving into the resistance mechanisms, this paper highlights the need to find alternate strategies to address the growing concern.

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“…In recent years, metallic nanostructures have seen an increasing interest in various fields due to their unique physical and chemical properties, allowing their use and application in different fields, ranging from biomedicine, , catalysis, , nanoelectronics, sensing, imaging, , and nanophotonics. − …”

Section: Introductionmentioning

confidence: 99%

Kinetics and Optimization of Hexagonal Palladium Nanosheets: Unveiling Insights into CO-Mediated Synthesis Strategies and Mechanistic Understanding

Rozenberg,

Zysler,

Zitoun

2023

Langmuir

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Metal nanoparticles: biomedical applications and their molecular mechanisms of toxicity

Cited by 16 publications

References 355 publications

Phytosynthesis of Silver Nanoparticles Using Leonurus cardiaca L. Extracts

Phytosynthesis of Silver Nanoparticles Using Leonurus cardiaca L. Extracts

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

Kinetics and Optimization of Hexagonal Palladium Nanosheets: Unveiling Insights into CO-Mediated Synthesis Strategies and Mechanistic Understanding

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