Metal‐Organic Framework‐Based Nanoheater with Photo‐Triggered Cascade Effects for On‐Demand Suppression of Cellular Thermoresistance and Synergistic Cancer Therapy

Abstract

Nanomedicine with stable light-heat conversion and spatiotemporally controllable drug activation is crucial for the success of photothermal therapy (PTT). Herein, a metal-organic framework (MOF)-based nanoheater with light-triggered multi-responsiveness is engineered to in-situ and on-demand sensitize cancer cells to local hyperthermia. Well-dispersed platinum nanoparticles synthesized inside nanospaces of the MOF are employed as the near-infrared (NIR)-harvesting unit with stable and high light-heat conversion performance. A conformation switchable polymer shell is constructed as a secondary light-responding unit to gate the targeted activation of a molecular inhibitor against thermoresistance. By cascade transformation of light stimuli to downstream signals, the nanoheater enables inhibitor release to go with local heating at the same time restricted in lesion sites to maximize efficacy and minimize systemic toxicity. The efficient photothermal conversion and the blockage of cellular heat-protective pathways provide a dual-mode of action which selectively sensitizes cancer cells to hyperthermia in a spatiotemporally controlled manner. With NIR as the remote switch, the MOF-based nanosystem demonstrates localized and boosted PTT efficacy against cancer both in vitro and in vivo. These results present nanosized MOFs as tailorable and versatile platforms for synergistic and precise cancer therapy.

Turning 3D Covalent Organic Frameworks into Luminescent Ratiometric Temperature Sensors

“…In this process, the inorganic NPs can be doped with any selected lanthanide system and then combined with the COF material into a nanocomposite. Because the developed procedure does not rely on any specific interaction, this method could qualify to become generalizable for the design of a wide range of NP/COF nanocomposites, with possible applications such as nanoheaters or catalysts. , …”

“…Because the developed procedure does not rely on any specific interaction, this method could qualify to become generalizable for the design of a wide range of NP/ COF nanocomposites, with possible applications such as nanoheaters or catalysts. 48,49 The employed NaYF 4 :Er,Yb NPs used in this study are among the best upconverting materials reported to date. 50 As shown in some of our previous works, they show three emission peaks upon excitation with a 975 nm continuous wavelength (CW) laser: 2 H 11/2 → 4 I 15/2 (520 nm), 4 S 3/2 → 4 I 15/2 (540 nm), and 4 F 9/2 → 4 I 15/2 (650 nm).…”

Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence

“…In terms of fluorescence imaging of cellular senescence, antibodies were used in combination with nanoparticles. Since nanoparticles can facilely accumulate in lesion sites in the body and be internalized into cells [ 82 ], antibodies thus can be carried to exert molecular recognition effects to imaging senescent-related processes in living biosystems.…”

Multi-luminescent center integrated metal–organic frameworks for high-performance white light-emitting diodes

“…7 Therefore, ideal WLEDs, with the features of CIE coordinates (0.33, 0.33), CCT between 2500 K and 6500 K and CRI above 80, will be highly desirable and urgently needed. [8][9][10] Recently emerging porous materials assembled by coordinating inorganic metal ions and organic ligands, metal-organic frameworks (MOFs), have attracted tremendous research attention in the fields of gas absorption and separation, 11 sensing, 12 lasing, 13 catalysis, 14 biomedicine, 15 and anti-counterfeiting, 16 owing to their high porosity as well as structural and chemical diversity. Since the first use of MOFs in WLEDs, these multifunctional materials have been demonstrated as an effective photonic platform for achieving white light emission.…”