Metal–Organic Framework Material Inhibits Biofilm Formation of Pseudomonas aeruginosa

Abstract

An 85% reduction in the bacterial attachment of Pseudomonas aeruginosa is achieved using a water‐stable metal–organic framework (MOF) blended with chitosan. These materials demonstrate this reduction in bacterial adhesion in the first 6 h and maintain it over the full 24 h exposure period, a remarkable impediment of biofilm formation to achieve, given the strength of this bacteria strain. The films elicit the same inhibitory effect after a second round of experiments, suggesting reusability of the materials. Characterization of the films by powder X‐ray diffraction, attenuated total reflectance‐IR, and scanning electron microscopy supports retention of the MOF structure within the chitosan matrix. The extensive control experiments employed in this study isolate the observed biological effects to the synthesized films, and not to possible leachates from the films. This presents the first account of using a water‐stable MOF within a polymer as a means to achieve an antibacterial surface by demonstrating an 85% reduction in bacterial attachment of Pseudomonas aeruginosa.

Blood‐Compatible Materials: Vascular Endothelium‐Mimetic Surfaces that Mitigate Multiple Cell‐Material Interactions

“…[ 48 ] Other work has also shown that NO‐releasing materials have broad‐spectrum antimicrobial activity. [ 15,28,40,58–64 ] The minimal observed antimicrobial properties of our NO‐releasing surfaces may be due to the amount of NO released. Previously published literature from our group has shown that 2.73 n m NO is required to produce a 90% reduction in bacterial biofilm viability.…”

“…Our group has demonstrated reduced protein adsorption, fibrin polymerization, and bacterial attachment by mimicking key features of the blood vessel endothelium. [ 14,15 ] This biomimetic strategy has successfully elucidated structure‐function relationships linking individual surface features to individual surface activities.…”

Depriving Bacterial Adhesion‐Related Molecule to Inhibit Biofilm Formation Using CeO2‐Decorated Metal‐Organic Frameworks

“…[9] At this stage, the bacterial resistance is weaker due to the lack of protection of mature bacterial biofilm. [10] The treatment of biofilm infections prior to the formation of a thick EPS would need only small doses of antibacterial agents for a shorter duration of time. [11] Therefore, inhibition of the biofilm formation is one of the promising avenues to confront drug resistance of bacteria.…”

Substrate Independent Liquid Phase Epitaxy of HKUST‐1 as Anticoagulant and Antimicrobial Coating

“…Either blend into matrix or growth on the surface, the HKUST-1 showed much improvement in the antibacterial capacity of biomaterials. For example, the chitosan/HKUST-1 composite materials have been developed for efficient inhibition of bacteria and therapy of local infection, [16] as well as surface-anchored HKUST-1 on cotton material for tunable antibacterial copper delivery. [2b] More recently, HKUST-1 has been proven to be durable and effective for generating antithrombotic NO.…”