Metal-Organic Frameworks for Bioimaging: Strategies and Challenges

Liu, Yanfei; Ji, Ting; Liu, Zhenbao

doi:10.7150/ntno.63458

Cited by 42 publications

(19 citation statements)

References 144 publications

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“…Metal–organic frameworks (MOFs) are a type of porous material with the characteristics of both organic molecules and inorganic compounds, which has many advantages, such as high stability, structural diversity, and strong designability. , These fascinating properties make MOFs extremely valuable in the fields of catalysis, , bioimaging, , gas storage and separation, , and so forth. Particularly, its unique luminescence behavior provides an excellent platform for the fluorescence sensing of biomarkers, , harmful gases, , anions and cations, , organic small molecules, , and other substances. , With the increasing application scope of MOFs in various fields, the application potential of chiral MOFs has gradually attracted the attention of researchers.…”

Section: Introductionmentioning

confidence: 99%

Zirconium Metal Organic Framework-Based Hybrid Sensors with Chiral and Luminescent Centers Fabricated by Postsynthetic Modification for the Detection and Recognition of Tryptophan Enantiomers

Yi-ping

Yan

2022

Inorg. Chem.

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By immobilizing the chiral center L-histidine (L-His) into a Zr-based metal−organic framework (MOF) through postsynthetic ligand exchange, a chiral compound MOF-His has been prepared. On this basis, MOF-His is hybridized with Eu 3+ ions to obtain the final responsive compound Eu@MOF-His. It is worth noting that the bifunctional material exhibits enantioselective luminescence properties for tryptophan enantiomers. The experimental results demonstrate that tryptophan enantiomers can effectively quench the red-light emission of Eu 3+ ions, and also, the quenching rates are various, which may originate from the differences in the interaction between analytes and chiral recognition sites. In addition, Eu@MOF-His can realize the sensing of tryptophan enantiomers in serum. Concurrently, the compound possesses reusability, high sensitivity, and fast response speed, which means that it has the potential to serve as an excellent fluorescent sensor for detecting and identifying tryptophan enantiomers.

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Section: Introductionmentioning

confidence: 99%

Zirconium Metal Organic Framework-Based Hybrid Sensors with Chiral and Luminescent Centers Fabricated by Postsynthetic Modification for the Detection and Recognition of Tryptophan Enantiomers

Yi-ping

Yan

2022

Inorg. Chem.

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“…As a new type of porous material, several nanoscale MOF (NMOF) has been tried to be used for cancer therapy by improving photothermal therapy (PTT), photodynamic therapy (PDT), radiotherapy (RT), and immunotherapy effects ( Bieniek et al, 2021 ; Mallakpour et al, 2022 ). At the same time, the contrasts of multi-modality images can be enhanced with the administration of NMOF, such as MRI, CT, ultrasound (US), and photoacoustic imaging (PAI), which is meaningful for interventional therapy and monitoring disease progression ( Wang, 2017 ; Bao et al, 2020 ; Liu et al, 2022 ). Additionally, benefitting from the abundant modification sites and stable structure, NMOF can be easily modified with a functional group for the synergetic enhancement.…”

Section: Introductionmentioning

confidence: 99%

Nano-Metal–Organic Framework Decorated With Pt Nanoparticles as an Efficient Theranostic Nanoprobe for CT/MRI/PAI Imaging-Guided Radio-Photothermal Synergistic Cancer Therapy

Mao

Qin

et al. 2022

Front. Bioeng. Biotechnol.

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The multifunctional theranostic nanoplatforms, which can realize changing the contrasts of medical images and enhance cancer therapies simultaneously, have attracted tremendous attention from chemists and medicine in past decades. Herein, a nanoscale metal–organic framework-based material was first synthesized and then decorated with platinum (NMOF545@Pt) successfully for multimodal imaging-guided synergistic cancer therapy. The obtained NMOF545@Pt is advantageous in shortening the longitudinal relaxation time (T1), enhancing photoacoustic effects, and elevating X-ray absorption efficiently. Thus, the enchantments of tripe imaging modalities, computed tomography (CT)/magnetic resonance imaging (MRI)/photoacoustic imaging (PAI), were realized with NMOF545@Pt administration simultaneously and can be cleared from the mice. Meanwhile, in vitro and in vivo experiments demonstrate that the synthesized NMOF545@Pt can dramatically increase photothermal therapy (PTT) and radiotherapy (RT) efficacy. Convincing evidence proves that tumor growth can be wholly inhibited without noticeable side effects or organ damage. The results demonstrated the promise of multifunctional nanocomposites NMOF545@Pt to improve biomedical imaging and synergistic tumor treatments.

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“…improves computed tomography (CT). Hf-UiO-66, PCN-224 improves thermal imaging [3,57]. MOFs show better performance in drug carrying and delivering than other carriers.…”

Section: Biomedical Industrymentioning

confidence: 98%

Advances with Metal Organic Framework based nanomaterials in 4th industrial revolution

Nipu¹,

Neogi²,

Choudhury³

2022

Proceedings of International Exchange and Innovation Conference on Engineering &Amp; Sciences (IEICES)

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Metal Organic Frameworks (MOFs) are expected to become a major player in different industrial sector as a result of biological performance, photocatalysis, adsorption and absorption behavior, capacitance, improved anodic performance in energy storage. In biomedical industries, MOFs utilize antimicrobial characteristics and biosensing, bioimaging, therapeutic, drug delivery capabilities. MOF can be used as a food safety and food packaging agent since they prevent microbes. By photocatalysis MOF can contribute to wastewater treatment. MOFs adsorption and absorption characteristics can remediate groundwater. Improved capacitance and anodic behavior of MOF will contribute to energy storage device improvement. MOFs are also capable of separating gases from mixtures. Thus, MOF will play vital role in biomedical, food, water-treatment industry, oil-gas industry, and energy storage industry. Energy, environment, biomedical applications make MOF important in 4 th industrial revolution. This study will focus on special properties along with different industrial application and show the effectiveness of MOF in 4 th industrial application.

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Metal-Organic Frameworks for Bioimaging: Strategies and Challenges

Cited by 42 publications

References 144 publications

Zirconium Metal Organic Framework-Based Hybrid Sensors with Chiral and Luminescent Centers Fabricated by Postsynthetic Modification for the Detection and Recognition of Tryptophan Enantiomers

Zirconium Metal Organic Framework-Based Hybrid Sensors with Chiral and Luminescent Centers Fabricated by Postsynthetic Modification for the Detection and Recognition of Tryptophan Enantiomers

Nano-Metal–Organic Framework Decorated With Pt Nanoparticles as an Efficient Theranostic Nanoprobe for CT/MRI/PAI Imaging-Guided Radio-Photothermal Synergistic Cancer Therapy

Advances with Metal Organic Framework based nanomaterials in 4th industrial revolution

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