Metal-organic layers-catalyzed amplification of electrochemiluminescence signal and its application for immunosensor construction

An electrochemiluminescence immunosensor based on multipath signal catalytic amplification integrated in a Cu2+–PEI–Pt/AuNC nanocomposite

“…To further verify the advantage of this proposed ECL immunosensor, the performance contrast compared to the previous methods for AFP detection is listed in Table 1, and the contrast results showed an obvious performance improvement of this proposed ECL immunosensor. 17–26…”

“…To further verify the advantage of this proposed ECL immunosensor, the performance contrast compared to the previous methods for AFP detection is listed in Table 1, and the contrast results showed an obvious performance improvement of this proposed ECL immunosensor. [17][18][19][20][21][22][23][24][25][26] The selectivity, stability and reproducibility, as important performance indicators, were also studied. First, carcinoembryonic antigen (CEA) and β2-microglobulin (β2-MG), as interfering agents, were applied to assess the selectivity.…”

Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors

“…In this context, Zhang and colleagues prepared a novel and efficient ECL emitter AuNP@Ir–Zr-MOL and employed it as a signal label to develop an immunosensor for the accurate determination of CEAs. 47 The 2D lamellar Zr-MOL was prepared using a solvothermal technique, followed by the coordination of Ir( iii ) onto the Zr-MOL structure. To enhance the electrical conductivity of Ir–Zr-MOL for potential conjugation with biological antibodies, a nanocomposite known as AuNP@Ir–Zr-MOL was fabricated through the reduction of HAuCl 4 on the Ir–Zr-MOL surface using NaBH 4 .…”

Framework-Enhanced Electrochemiluminescence in Biosensing

“…On the other hand, MOFs were utilized as a coreactant accelerator to enhance the ECL of CdTe QDs through accelerating the generation of the sulfate radical anion (SO4 •− ) which is critical in producing excited states of QDs, further realizing an ultrasensitive bioanalysis of the cardiac troponin-I antigen [41]. Similarly, 2D Fe-Zr metal-organic layers were applied for the construction of an ECL immunosensor by utilizing their peroxidaselike activity, which could effectively enhance the ECL signal of luminol through H2O2 catalysis [42]. Additionally, Song et al designed a signal-amplified ECL sensor chip via the synergistic catalysis of Au-Pd bimetallic nanocrystals and mixed-valence Ce-based MOFs for the fast reduction of dissolved O2 (Figure 3b).…”