Metal oxide nanoparticles for the decontamination of toxic chemical and biological compounds

Denet, Elodie; Espina-Benitez, Maria Betzabeth; Pitault, Isabelle; Pollet, T.; Blaha, Didier; Bolzinger, Marie‐Alexandrine; Rodríguez-Nava, Verónica; Briançon, Stéphanie

doi:10.1016/j.ijpharm.2020.119373

Cited by 31 publications

(19 citation statements)

References 81 publications

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“…Comparing with previous reports of MO NPs, ZnO NPs had 0.1-57.9% survival rates against E. coli (10 6 ), conversely at 0.01-1 mg/mL [41]. MgO NPs at 100 mg/mL were bactericidal against E. coli after 1-h incubation despite no antibacterial performance against S. aureus within 3-h incubation [42]. In addition, CuO NPs at 25 and 50 µg/mL showed 87% and 92% growth inhibition rates against E. coli after 16-h incubation although the growth inhibition rates were not significantly reduced at approximately 2.11% for both concentrations after 1-h incubation [43].…”

Section: Discussioncontrasting

confidence: 46%

Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Jin

2021

Pharmaceutics

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Antimicrobial activity of multiscale metal oxide (MO) particles against Escherichia coli (E. coli) and M13 bacteriophage (phage) was investigated under dual ultraviolet (UV) irradiation. Zinc oxide (ZnO), magnesium oxide (MgO), cuprous oxide (Cu2O), and cupric oxide (CuO) were selected as photocatalytic antimicrobials in MO particles. Physicochemical properties including morphology, particle size/particle size distribution, atomic composition, crystallinity, and porosity were evaluated. Under UV-A and UV-C irradiation with differential UV-C intensities, the antimicrobial activity of MO particles was monitored in E. coli and phage. MO particles had nano-, micro- and nano- to microscale sizes with irregular shapes, composed of atoms as ratios of chemical formulae and presented crystallinity as pure materials. They had wide-range specific surface area levels of 0.40–46.34 m2/g. MO particles themselves showed antibacterial activity against E. coli, which was the highest among the ZnO particles. However, no viral inactivation by MO particles occurred in phage. Under dual UV irradiation, multiscale ZnO and CuO particles had superior antimicrobial activities against E. coli and phage, as mixtures of nano- and microparticles for enhanced photocatalytic antimicrobials. The results showed that the dual UV-multiscale MO particle hybrids exhibit enhanced antibiotic potentials. It can also be applied as a next-generation antibiotic tool in industrial and clinical fields.

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Section: Discussioncontrasting

confidence: 46%

Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Jin

2021

Pharmaceutics

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“…Metal oxide NPs such as iron oxide (Fe 3 O 4 ), zinc oxide (ZnO), copper oxide (CuO), magnesium oxide (MgO) and titanium dioxide (TiO 2 ) are known to have antibacterial properties over both Gram positive and Gram negative bacteria [ 68 , 69 , 70 ]. Their mode of action is based on ROS release through the Fenton reaction, intrinsic photocatalytic activity and the release of metallic ions [ 71 , 72 ].…”

Section: Presentation Of Npsmentioning

confidence: 99%

Nanomaterials as a Successor of Antibiotics in Antibiotic-Resistant, Biofilm Infected Wounds?

Nowak

Barańska‐Rybak

2021

Antibiotics

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Chronic wounds are a growing problem for both society and patients. They generate huge costs for treatment and reduce the quality of life of patients. The greatest challenge when treating a chronic wound is prolonged infection, which is commonly caused by biofilm. Biofilm makes bacteria resistant to individuals’ immune systems and conventional treatment. As a result, new treatment options, including nanomaterials, are being tested and implemented. Nanomaterials are particles with at least one dimension between 1 and 100 nM. Lipids, liposomes, cellulose, silica and metal can be carriers of nanomaterials. This review’s aim is to describe in detail the mode of action of those molecules that have been proven to have antimicrobial effects on biofilm and therefore help to eradicate bacteria from chronic wounds. Nanoparticles seem to be a promising treatment option for infection management, which is essential for the final stage of wound healing, which is complete wound closure.

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“…Wagner et al developed self-decontamination paints for military vehicles based on TiO 2 for the hydrolysis of VX, GD and HD [ 57 ]. The antibacterial activity of metal oxide NPs is also well-known [ 58 ]. ZnO and MgO have been proved to inhibit the growth of Pseudomonas aeruginosa and Staphylococcus aureus ( S. aureus ) [ 59 ], Xanthomonas oryzae pv.…”

Section: Nanoparticlesmentioning

confidence: 99%

Protective Multifunctional Fibrous Systems Based on Natural Fibers and Metal Oxide Nanoparticles

2021

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In recent years, an unprecedented increase in the development of products and technologies to protect the human being has been observed. Now, more than ever, the world population is exposed to several threats, harmful to their well-being and health. Chemical and biological hazardous agents stand out as one of the biggest threats, not only for the military forces, but also for the civilians. Consequently, it’s essential to develop personal protective systems that are able to protect their user, not only passively, but actively, being able to detect, adsorb, degrade and decontaminate pesticides, pollutants, microorganisms and most importantly: chemical/biological warfare agents. One recent strategy for the development of active fibrous structures with improved functions and new properties is their functionalization with nanoparticles (NPs), especially metal oxides. Although their known effectiveness in the decomposition of harmful agents, the NPs could also include other functionalities in the same structure using low quantities of material, without adding extra weight, which is of huge importance for a soldier in the battlefield. The use of natural fibers as the substrate is also very interesting, since this material is a much sustainable alternative when compared to synthetic ones, also providing excellent properties.

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Metal oxide nanoparticles for the decontamination of toxic chemical and biological compounds

Cited by 31 publications

References 81 publications

Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Nanomaterials as a Successor of Antibiotics in Antibiotic-Resistant, Biofilm Infected Wounds?

Protective Multifunctional Fibrous Systems Based on Natural Fibers and Metal Oxide Nanoparticles

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