2023
DOI: 10.1039/d3mh00033h
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Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Abstract: Living probiotics secrete bioactive substances to accelerate wound healing, but the clinical application of antibiotics inhibits the survival of probiotics. Inspired by the chelation of tannic acid and ferric ions,...

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Cited by 17 publications
(13 citation statements)
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“…Schiff base hydrogel exhibited small pores distributed throughout its structure, facilitating the storage and diffusion of water molecules. I 2 /HP-β-CD hydrogel revealed an even distribution of the embedding materials on the hydrogel fibers, creating a moist and bactericidal environment that fosters a favorable setting for cell proliferation and differentiation . In addition, as shown in Figure f, the red blood cells exhibited a smooth and intact appearance when observed through inverted microscopy of the hydrogel extracts employed in the coagulation experiments.…”
Section: Resultsmentioning
confidence: 93%
See 1 more Smart Citation
“…Schiff base hydrogel exhibited small pores distributed throughout its structure, facilitating the storage and diffusion of water molecules. I 2 /HP-β-CD hydrogel revealed an even distribution of the embedding materials on the hydrogel fibers, creating a moist and bactericidal environment that fosters a favorable setting for cell proliferation and differentiation . In addition, as shown in Figure f, the red blood cells exhibited a smooth and intact appearance when observed through inverted microscopy of the hydrogel extracts employed in the coagulation experiments.…”
Section: Resultsmentioning
confidence: 93%
“…I 2 /HP-β-CD hydrogel revealed an even distribution of the embedding materials on the hydrogel fibers, creating a moist and bactericidal environment that fosters a favorable setting for cell proliferation and differentiation. 40 In addition, as shown in Figure 3f, the red blood cells exhibited a smooth and intact appearance when observed through inverted microscopy of the hydrogel extracts employed in the coagulation experiments. DAC can quickly absorb liquid in blood and capture proteins, platelets, and red blood cells.…”
Section: Synthesis and Characterization Of Hydrogelsmentioning
confidence: 81%
“…Lu et al 22 used heparin-poloxamer (HP) hydrogels to load Lactococcus lactis, which can continuously induce VEGF secretion, and achieve dynamic and continuous delivery of VEGF and lactic acid on chronic wound surfaces to accelerate wound repair. Zhou et al 23 developed a metal-phenolic self-assembled shielded probiotic that can regulate inflammation, angiogenesis, and tissue regeneration in the presence of antibiotics. Sun et al 24 prepared Lactobacillus reuteri (L. reuteri)-laden alginate microspheres (AlgMPs) and further synthesized the hydrogel dressing.…”
Section: Introductionmentioning
confidence: 99%
“…34,35 The exposed probiotics on wounds may cause attacks by the immune system, which is detrimental to viability of applied probiotics and even desired therapeutic effectiveness. 36 Thus, the core challenge in probiotic therapy remains to seek efficiently polymerized and microenvironmentally benign culture-delivery systems with sufficiently safe and long-term package activity.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, extensive delivery scaffolds have been established to support wound healing. , Hydrogels, in particular, have emerged as the most promising contenders for clinical applications. , This is due to their remarkable hydrophilicity, biocompatibility, and 3D porous structure to resemble the extracellular matrix, as well as generating a relatively uniform distribution of cells . Numerous infected wounds hydrogel dressings for packaging and delivering various antimicrobial substances are becoming highly sought after. However, large amounts of investigated dressings require 10–30 s to gel, which may pose a threat to the effectiveness of carried live cells or probiotics and significantly retard the convenience of operation. , Moreover, many cultivation and delivery systems lack adequate mechanical performance and protective structural design, severely limiting the long-term viability and leakage prevention of probiotics. , The exposed probiotics on wounds may cause attacks by the immune system, which is detrimental to viability of applied probiotics and even desired therapeutic effectiveness . Thus, the core challenge in probiotic therapy remains to seek efficiently polymerized and microenvironmentally benign culture-delivery systems with sufficiently safe and long-term package activity.…”
Section: Introductionmentioning
confidence: 99%