Metal-polyphenol nanodots loaded hollow MnO2 nanoparticles with a “dynamic protection” property for enhanced cancer chemodynamic therapy

Duan, Junlin; Liao, Tao; Xu, Xiangyu; Liu, Yun; Kuang, Ying; Li, Cao

doi:10.1016/j.jcis.2022.12.088

Cited by 36 publications

(16 citation statements)

References 57 publications

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“…Meanwhile, Mn 2+ can induce the Fenton‐like reaction to produce ·OH. [ 41 ] The novelty of this work is smart integration of two natural proteins for controlled and targeted delivery of an apoptotic agent (LAP) and an immune stimulator to tumor cells and dendritic cells, respectively. The pH‐responsive linker was another shining point, which enabled the identical pharmacokinetics and biodistribution of both cargos, and enhanced the tumor penetration of disassembled albumin and ferritin because tumor penetration of nanocarriers is favored by reduced particle size.…”

Section: Nanocarriers For Beta‐lapachone Deliverymentioning

confidence: 99%

Tailored Beta‐Lapachone Nanomedicines for Cancer‐Specific Therapy

Feng

Guo

Wang

et al. 2023

Adv Healthcare Materials

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Nanotechnology shows the power to improve efficacy and reduce the adverse effects of anticancer agents. As a quinone‐containing compound, beta‐lapachone (LAP) is widely employed for targeted anticancer therapy under hypoxia. The principal mechanism of LAP‐mediated cytotoxicity is believed due to the continuous generation of reactive oxygen species with the aid of NAD(P)H: quinone oxidoreductase 1 (NQO1). The cancer selectivity of LAP relies on the difference between NQO1 expression in tumors and that in healthy organs. Despite this, the clinical translation of LAP faces the problem of narrow therapeutic window that is challenging for dose regimen design. Herein, the multifaceted anticancer mechanism of LAP is briefly introduced, the advance of nanocarriers for LAP delivery is reviewed, and the combinational delivery approaches to enhance LAP potency in recent years are summarized. The mechanisms by which nanosystems boost LAP efficacy, including tumor targeting, cellular uptake enhancement, controlled cargo release, enhanced Fenton or Fenton‐like reaction, and multidrug synergism, are also presented. The problems of LAP anticancer nanomedicines and the prospective solutions are discussed. The current review may help to unlock the potential of cancer‐specific LAP therapy and speed up its clinical translation.

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Section: Nanocarriers For Beta‐lapachone Deliverymentioning

confidence: 99%

Tailored Beta‐Lapachone Nanomedicines for Cancer‐Specific Therapy

Feng

Guo

Wang

et al. 2023

Adv Healthcare Materials

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“…Lotus procyanidins have been shown to have potent antioxidant activity and have been shown to improve memory deficits and oxidative damage in polyamine-induced amnesic mice, SAMP8, and cognitively impaired aged rats. ,,, Probiotics are thought to contribute to the balance of gut microecology and gut health, − and both probiotics and lotus procyanidins have been shown to have memory-enhancing and gut-modulation effects. There is a two-way interaction between probiotics and lotus procyanidins. , Li et al found that lotus procyanidins did not affect the growth of Lactobacillus casei-01 at concentrations of 0.25 and 0.5 mg/mL in vitro .…”

Section: Interaction Of Lotus Procyanidins With Other Nutrient Compon...mentioning

confidence: 99%

Extraction Methods, Properties, Functions, and Interactions with Other Nutrients of Lotus Procyanidins: A Review

Wu,

Zhang,

Niu

et al. 2023

J. Agric. Food Chem.

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Lotus procyanidins, natural polyphenolic compounds isolated from the lotus plant family, are widely recognized as potent antioxidants that scavenge free radicals in the human body and exhibit various pharmacological effects, such as antiinflammatory, anticancer, antiobesity, and hypoglycemic. With promising applications in food and healthcare, lotus procyanidins have attracted extensive attention in recent years. This review provides a comprehensive summary of current research on lotus procyanidins, including extraction methods, properties, functions, and interactions with other nutrient components. Furthermore, this review offers an outlook on future research directions, providing ideas and references for the exploitation and utilization of lotus.

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“…13,14 However, overexpression of intracellular glutathione (GSH) in tumor cells, which has a strong scavenging effect on ROS, is an obstacle for CDT. [15][16][17] Thus, reducing the level of intracellular GSH is desirable to avoid tumor resistance and improve the efficacy of CDT. [18][19][20] Tai et al reported a novel bimetallic Cu(II) complex enhancing CDT by oxidizing GSH into glutathione (GSSG).…”

Section: Introductionmentioning

confidence: 99%