Metallaphotoredox-Catalyzed C−H Activation: Regio-Selective Annulation of Allenes with Benzamide

Li, Tianlei; Li, Jishun; Zhu, Zhihong; Chen, Yu-Yuan; Li, Xueyao; Yang, Qi; Xia, Jie; Zhang, Wenxuan; Zhang, Chao; PAN, Wiedong; Wu, Song

doi:10.21203/rs.3.rs-62788/v1

Cited by 6 publications

(17 citation statements)

References 41 publications

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“…To solve clinical problems with the utility of PET/CT as quantitative criteria, different indicators are used: SUV max , metabolic tumor volume (MTV), total lesion glycolysis (TLG), average ratio of the tumor-to-background radioactivity (TBR), standardized uptake peak value determined within the VOI of the fixed size (SUV peak ), etc. [13][14][15][16][17][18]. The most common one among them is SUV max , which is determined by the semiquantitative method [15].…”

Section: Discussionmentioning

confidence: 99%

“…phantom was scanned four times on each of the tested scanners: a Discovery 690 (General Electric, USA), a Biograph mCT 128 (Siemens, Germany), and a Biograph mCT 40 (Siemens) using the clinical protocols used for patients. Before each new scan, 18 F was added to the total volume of the phantom to create a different ratio of the sphere-main volume. The analysis of the phantom images consisted of measuring radioactivity in the main volume of the phantom and in the spheres, as well as calculating the ratios of sphere-main volume.…”

Section: Methodsmentioning

confidence: 99%

“…The radioactivity of 18 F was measured using a verified Curiementor 4 dose calibrator (PTW-Freiburg, Germany) with a relative 5% error in activity measuring. For each sphere, the volumes of interest were determined using automatic delineation in order to measure the maximum value of activity concentration.…”

Section: Methodsmentioning

confidence: 99%

“…The preparation of patients prior to the scan was standardized. The study was limited to scanning one anatomical region -the thoracic region -and started 70-90 min after intravenous administration of 18 F-FDG with the activity of 110 MBq per unit of the patient's body surface area. The scan protocol consisted of a topogram, helical CT scan without contrast enhancement for attenuation correction, and PET scan.…”

Section: Methodsmentioning

confidence: 99%

“…The aim of this study was to estimate the accuracy of the evaluation of the standardized uptake values of 18 F-fluorodeoxyglucose ( 18 F-FDG) in lung lesions when performing positron emission tomography combined with computed tomography (PET/CT), based on phantom studies performed for different PET/CT scanners.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Accuracy of Standardized Uptake Values of 18F-fluorodeoxyglucose in Lung Lesions Based on Phantom Studies

Тлостанова¹,

Чипига²

2021

Sovrem Tehnol Med

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The aim of the study was to estimate the accuracy of standardized uptake values of 18 F-fluorodeoxyglucose ( 18 F-FDG) in lung lesions during positron emission tomography combined with computed tomography (PET/CT) imaging, based on phantom studies performed for different PET/CT scanners.Materials and Methods. The analysis of the PET/CT with 18 F-FDG data was performed for 86 patients newly diagnosed with the lung lesions: malignant tumors (n=37), benign tumors and inflammatory diseases (n=49). The criteria for inclusion in the study were developed considering the recommendations of the Fleischner Society (2017). The characteristics of the lesions on CT met the following requirements: a round shape or close to it; total size of 8 to 30 mm; solid or subsolid structure (with the exception of lesion with ground-glass opacity); a solid part size of ≥8 mm. All the patients had no signs of pleurisy, lymphadenopathy, or cancer history. PET/CT imaging with 18 F-FDG was performed with three scanners: Discovery 690 (General Electric, USA), Biograph mCT 128 (Siemens, Germany), and Biograph mCT 40 (Siemens); the preparation of patients prior to the scan was standardized. To determine the reference accumulation of a radiopharmaceutical in the pathological lesion, four scans of a specialized NEMA IEC PET Body Phantom Set (USA) were performed for each scanner. For each unit, the recovery coefficients (RCs) of radioactivity, maximum and recovered (corrected) standardized uptake values (SUVs) were determined. Statistical relationship between the size of lesions, SUV max and SUV correct was evaluated. Data processing was performed using MedCalc v. 19.2.0 software.Results. During the phantom study, the underestimation of the radioactivity was determined in the spheres with the diameters of 10 and 13 mm, overestimation was observed in the sphere with the diameter of 28 mm. Both underestimation and overestimation of radioactivity were determined for the spheres with a diameter of 17 and 22 mm.SUV max differed from the reference values for 85 patients (98.8%). The underestimation of these values was found for 63 patients (73.2%) due to the partial volume effect. The greatest underestimation was observed for the patients with 8 mm diameter lesions. Depending on the scanner, the underestimation of the SUV max in these patients reached up to 54-73%. For 9 patients (25%) with malignant tumors of 9-12 mm, the utility of RC made it possible to avoid false negative results. For the lesions with a diameter of 30 mm, an overestimation of SUV max up to 22% was determined due to the negative influence of the reconstruction algorithms.Conclusion. The use of RC eliminates the influence of the partial volume effect and reconstruction methods on the accuracy of estimating the SUV max in lung lesions, which ensures reproducibility, increase in the information content of the method, as well as the comparability of the results of PET/CT with 18 F-FDG obtained on the different models of PET/CT units with different technological characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Accuracy of Standardized Uptake Values of 18F-fluorodeoxyglucose in Lung Lesions Based on Phantom Studies

Тлостанова¹,

Чипига²

2021

Sovrem Tehnol Med

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Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Wang

Chen

Sun

et al. 2023

J of Separation Science

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Neuraminidase is an important target in the treatment of the influenza A virus.Screening natural neuraminidase inhibitors from medicinal plants is crucial for drug research. This study proposed a rapid strategy for identifying neuraminidase inhibitors from different crude extracts (Polygonum cuspidatum, Cortex Fraxini, and Herba Siegesbeckiae) using ultrafiltration combined with mass spectrometry guided by molecular docking. Firstly, the main component library of the three herbs was established, followed by molecular docking between the components and neuraminidase. Only the crude extracts with numbers of potential neuraminidase inhibitors identified by molecular docking were selected for ultrafiltration. This guided approach reduced experimental blindness and improved efficiency. The results of molecular docking indicated that the compounds in Polygonum cuspidatum demonstrated good binding affinity with neuraminidase. Subsequently, ultrafiltration-mass spectrometry was employed to screen for neuraminidase inhibitors in Polygonum cuspidatum. A total of five compounds were fished out, and they were identified as trans-polydatin, cispolydatin, emodin-1-O-β-D-glucoside, emodin-8-O-β-D-glucoside, and emodin.The enzyme inhibitory assay showed that they all had neuraminidase inhibitory effects. In addition, the key residues of the interaction between neuraminidase and fished compounds were predicted. In all, this study could provide a strategy for the rapid screening of the potential enzyme inhibitors from medicinal herbs.

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Opposing Effects of Side-Chain Flexibility and Hydrogen Bonding on the Thermal, Mechanical, and Rheological Properties of Supramolecularly Cross-Linked Polyesters

et al. 2018

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We report the design of a series of polyesters containing pendant secondary amide groups to probe the cumulative effects of hydrogen bonding and chain flexibility on their thermal, mechanical, and rheological properties. Reported studies on polymers with secondary amide groups have usually focused on the effect of hydrogen bonding interactions on the mechanical, selfassembly, or self-healing properties, whereas the effect of chain flexibility has often been overlooked. In an effort to probe the cumulative effects of hydrogen bonding and chain flexibility, in this work polyesters were designed with either one or two pendant secondary amide-propyl groups and compared to a control polyester with one pendant ester-propyl group. The results show that hydrogen bonding increases glass transition temperature (T g ), Young's modulus, and polymer brittleness. But at higher temperature (T g + 50 °C), rheometry shows that the polyester containing two amide groups has the shortest chain relaxation time and the lowest zero-shear rate viscosity (η 0 ). These results are counterintuitive, since the polymer with two hydrogen bonding amide groups was expected to relax more slowly and have higher viscosity. Our results demonstrate the opposing effects of side-chain flexibility and hydrogen bonding interactions can be used as a strategy to design materials with desired rheological properties.

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Metallaphotoredox-Catalyzed C−H Activation: Regio-Selective Annulation of Allenes with Benzamide

Cited by 6 publications

References 41 publications

Evaluation of the Accuracy of Standardized Uptake Values of 18F-fluorodeoxyglucose in Lung Lesions Based on Phantom Studies

Evaluation of the Accuracy of Standardized Uptake Values of 18F-fluorodeoxyglucose in Lung Lesions Based on Phantom Studies

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Opposing Effects of Side-Chain Flexibility and Hydrogen Bonding on the Thermal, Mechanical, and Rheological Properties of Supramolecularly Cross-Linked Polyesters

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