The tubular architecture with multiple components can bring synergistic effects to improve the enzyme-like activity of molybdenum-based nanomaterials. Here, a facile polypyrrole (PPy)-protected hydrothermal sulfidation process was implemented to engineer MoS 2 /Ag 2 S heterointerfaces encapsulated in one-dimensional (1D) PPy nanotubes with MoO 3 @Ag nanorods as the selfsacrificing precursor. Notably, the sulfidation treatment led to the generation of MoS 2 nanosheets (NSs) and Ag 2 S nanoparticles (NPs) and the creation of a tubular structure with a "kill three birds with one stone" role. The Ag 2 S/MoS 2 @ PPy nanotubes showed the synergistic combined effects of Ag 2 S NPs, MoS 2 NSs, and the 1D tube-like nanostructure. Based on the synergistic effects from these multiple components and the tubular structure, Ag 2 S/MoS 2 @PPy nanocomposites were used as a colorimetric sensing platform for detecting H 2 O 2 . Moreover, the reduction of 4-nitrophenol (4-NP) revealed excellent catalytic activity in the presence of NaBH 4 and Ag 2 S/MoS 2 @PPy nanocomposites. This work highlights the effects of MoS 2 /Ag 2 S heterointerfaces and the hierarchical tubular structure in catalysis, thereby providing a new avenue for reducing 4-NP and the enzyme-like catalytic field.