Metallic Nanocluster-Based Sniffing Device for Identification of Malignancy in Gastric Cancer Tissues

Sharifi, Hoda; Tashkhourian, Javad; Geramizadeh, Bita; Ghohestani, Elham; Zangouri, Vahid; Asadian, Fatemeh; Hemmateenejad, Bahram

doi:10.1021/acsanm.3c00029

Cited by 8 publications

(3 citation statements)

References 62 publications

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“…To get a better understanding of any data set, an unsupervised method (PCA) is often complimented with a supervised method (PLS-DA) . PLS-DA, unlike PCA, considers the labels of the observations, and PLS-DA is particularly helpful in the selection of features of the array in addition to dimension reduction.…”

Section: Resultsmentioning

confidence: 99%

Identification and Quantification of Aqueous Disinfectants Using an Array of Carbon Nanotube-Based Chemiresistors

Akbar,

Sharif,

Selvaganapathy

et al. 2023

ACS Appl. Eng. Mater.

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Disinfection of water is essential to prevent the growth of pathogens, but at high levels, it can cause harm to human health. Therefore, accurate monitoring of disinfectant concentrations in water is essential to ensure safe drinking water. The use of multiple disinfectants at different stages in water treatment plants makes it necessary to also identify the type and concentrations of all of the disinfectant species present. Here, we demonstrate an effective approach to identify and quantify multiple disinfectants (using the example of free chlorine and potassium permanganate) in water using single-walled carbon nanotube (SWCNT)-based reagent-free chemiresistive sensing arrays. Facile fabrication of chemiresistive devices makes them a popular choice for the implementation of sensor arrays. Our sensing array consists of functionalized and unfunctionalized (blank) SWCNT sensors to distinguish the disinfectants. The distinct responses from the different sensors at varying concentrations and pH can be fitted to the mathematical model of a Langmuir adsorption isotherm separately for each sensor. Blank and functionalized sensors respond through different mechanisms that result in varying responses that are concentration-and pH-dependent. Chemometric techniques such as principal component analysis (PCA) and partial least-squares-discriminant analysis (PLS-DA) were used to analyze the sensor data. PCA showed an excellent separation of the analytes over five different pHs (5.5, 6.5, 7.5, 8.5, and 9.5). PLS-DA provided excellent separability as well as good predictability with a Q 2 of 94.26% and an R 2 of 95.67% for the five pH regions of the two analytes. This proof-of-concept solid-state chemiresistive sensing array can be developed for specific disinfectants that are commonly used in water treatment plants and can be deployed in water distribution and monitoring facilities. We have demonstrated the applicability of chemiresistive devices in a sensor array format for the first time for aqueous disinfectant monitoring.

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Section: Resultsmentioning

confidence: 99%

Identification and Quantification of Aqueous Disinfectants Using an Array of Carbon Nanotube-Based Chemiresistors

Akbar,

Sharif,

Selvaganapathy

et al. 2023

ACS Appl. Eng. Mater.

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“…Nanoarray analysis can distinguish GC patients from the control group with 73% sensitivity, 98% specificity, and 92% accuracy. Sharifi et al [106] developed an electronic nose device containing eight fluorescent metal nanoclusters (NCs) sensing elements fixed on a paper substrate to detect VOCs released by the human body. After entering the headspace of the tissue, the emitted VOC reacts with the NC, causing the fluorescence intensity of the NC to change.…”

Section: Gastric Disease Sensing and Detectionmentioning

confidence: 99%

Application of Sensing Devices in the Detection of Oral, Pulmonary, and Gastrointestinal Diseases

Yu,

Mou,

Zhang

et al. 2024

Chemosensors

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Biomedical sensing technology is developing at a tremendous pace and is expected to become an effective clinical tool for the diagnosis and monitoring of human health. The development of sensing devices has successfully transformed the specific sensor prototype designed in the laboratory into a commercially feasible clinical disease detection device. Recently, sensing devices have been accelerated and extended to various fields beyond disease detection, including the measurement of gastrointestinal physiological parameters such as pH, VOC detection, small-molecule gas sensing, and noninvasive screening of oral and lung diseases such as oral cancer, gastric cancer, and other major diseases. In this review, the applications of sensors and electronic nose devices in the diagnosis and monitoring of oral, pulmonary, and gastrointestinal diseases are reviewed, as well as the design and application of sensor materials in disease markers and in situ detection. This article also introduces the practical application of sensing devices in human disease detection, critically analyzes their detection mechanisms and clinical utility, and discusses their future development in medicine. We believe that this review will help readers, especially practitioners in the medical field, provide ideas for the development of sensing devices.

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“…Not only environmental pollutants, protein engineered QDs based sensor arrays also used for discrimination of VOCs emitted from diseased tissue sample. [69] Apart from small molecules and polymers, supramolecular host molecules are also engineered on QDs surface for sensing of pollutants. Calixarene and cyclodextrin units were grafted on CdSe/ZnS QDs and AuNCs for detection of explosive nitroaromatics [70] where the quenching mechanism was attributed to primary inner filter effect (IFE) (Figure 14a).…”

Section: Detection Of Small Moleculesmentioning

confidence: 99%

Surface‐Engineered Nanomaterials for Optical Array Based Sensing

Behera,

2023

ChemPlusChem

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Array based sensing governed by optical methods provides fast and economic way for detection of wide variety of analytes where the ideality of detection processes depends on the sensor element‘s versatile mode of interaction with multiple analytes in an unbiased manner. This can be achieved by either the receptor unit having multiple recognition moiety, or their surface property should possess tuning ability upon fabrication called surface engineering. Nanomaterials have a high surface to volume ratio, making them viable candidates for molecule recognition through surface adsorption phenomena, which makes it ideal to meet the above requirements. Most crucially, by engineering a nanomaterial's surface, one may produce cross‐reactive responses for a variety of analytes while focusing solely on a single nanomaterial. Depending on the nature of receptor elements, in the last decade the array‐based sensing has been considering as multimodal detection platform which operates through various pathway including single channel, multichannel, binding and indicator displacement assay, sequential ON‐OFF sensing, enzyme amplified and nanozyme based sensing etc. In this review we will deliver the working principle for Array‐based sensing by using various nanomaterials like nanoparticles, nanosheets, nanodots and self‐assembled nanomaterials and their surface functionality for suitable molecular recognition.

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Metallic Nanocluster-Based Sniffing Device for Identification of Malignancy in Gastric Cancer Tissues

Cited by 8 publications

References 62 publications

Identification and Quantification of Aqueous Disinfectants Using an Array of Carbon Nanotube-Based Chemiresistors

Identification and Quantification of Aqueous Disinfectants Using an Array of Carbon Nanotube-Based Chemiresistors

Application of Sensing Devices in the Detection of Oral, Pulmonary, and Gastrointestinal Diseases

Surface‐Engineered Nanomaterials for Optical Array Based Sensing

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