Metallic Nanoparticles: General Research Approaches to Immunological Characterization

Gatto, Francesca; Bardi, Giuseppe

doi:10.3390/nano8100753

Cited by 23 publications

(15 citation statements)

References 136 publications

(144 reference statements)

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“…Nanoparticles have been considered as valuable means in medicinal discipline by the reason of their high surface area to volume ratio and consequence versatility [ 34 , 35 ]. Indeed, nanoparticle-based biomaterials can interact with several biomolecules [ 36 ], resulting in being employed to several biomedical areas—e.g., drug delivery, tissue engineering, and dentistry [ 37 ]. Although there are several studies applying calcium silicate nanoparticle-based sealers in root canal treatment [ 38 , 39 ], there are few studies exploring the bioactivity of calcium silicate nanoparticle-incorporated sealers.…”

Section: Introductionmentioning

confidence: 99%

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

Kim

Lee

et al. 2020

Nanomaterials

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Calcium silicate-based bioactive glass has received significant attention for use in various biomedical applications due to its excellent bioactivity and biocompatibility. However, the bioactivity of calcium silicate nanoparticle-incorporated bioactive dental sealer is not much explored. Herein, three commercially available bioactive root canal sealers (Endoseal MTA (EDS), Well-Root ST (WST), and Nishika Canal Sealer BG (NBG)) were compared with a resin-based control sealer (AH Plus (AHP)) in terms of physical, chemical, and biological properties. EDS and NBG showed 200 to 400 nm and 100 to 200 nm nanoparticle incorporation in the SEM image, respectively, and WST and NBG showed mineral deposition in Hank’s balanced salt solution after 28 days. The flowability and film thickness of all products met the ISO 3107 standard. Water contact angle, linear dimensional changes, and calcium and silicate ion release were significantly different among groups. All bioactive root canal sealers released calcium ions, while NBG released ~10 times more silicon ions than the other bioactive root canal sealers. Under the cytocompatible extraction range, NBG showed prominent cytocompatibility, osteogenecity, and angiogenecity compared to other sealers in vitro. These results indicate that calcium silicate nanoparticle incorporation in dental sealers could be a potential strategy for dental periapical tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

Kim

Lee

et al. 2020

Nanomaterials

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“…In this sense, understanding which physicochemical properties are coupled with adverse effects is critical for designing safer and more effective nanomaterials for cancer treatment. This so-called "Safe(r)-by-Design" approach requires the implementation of safety evaluation early in the development of nanomaterials [247], together with understanding their toxicokinetics and modulation of the immune system [248][249][250].…”

Section: Biosafety Of Soft Nanocarriersmentioning

confidence: 99%

Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives

Buociková

Ríos-Mondragón

Pilalis

et al. 2020

Cancers

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Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. Although the efficacy of the first-generation epigenetic drugs (epi-drugs) in solid tumor management has been disappointing, there is an increasing body of evidence showing that epigenome modulation, in synergy with other therapeutic approaches, could play an important role in cancer treatment, reversing acquired therapy resistance. However, the epigenetic therapy of solid malignancies is not straightforward. The emergence of nanotechnologies applied to medicine has brought new opportunities to advance the targeted delivery of epi-drugs while improving their stability and solubility, and minimizing off-target effects. Furthermore, the omics technologies, as powerful molecular epidemiology screening tools, enable new diagnostic and prognostic epigenetic biomarker identification, allowing for patient stratification and tailored management. In combination with new-generation epi-drugs, nanomedicine can help to overcome low therapeutic efficacy in treatment-resistant tumors. This review provides an overview of ongoing clinical trials focusing on combination therapies employing epi-drugs for breast cancer treatment and summarizes the latest nano-based targeted delivery approaches for epi-drugs. Moreover, it highlights the current limitations and obstacles associated with applying these experimental strategies in the clinics.

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“…Gold nanoparticles of 10 nm inhibited the expression of CD86, CD83, MHC II, and IL-12p70 induced by LPS treatment in DCs [119]. It is hypothesized that immune cells can recognize nanoparticles due to the presence of surface-adsorbed biomolecules, or recognize specific structures of the nanomaterial, which are designated as nanoparticle-associated molecular patterns (NAMPs) [120,121]. Similar to pristine nanoparticles, nanoparticle-antigen conjugates are shown to enhance the maturation of APCs.…”

Section: Maturation Of Apcsmentioning

confidence: 99%

Nanotechnology-Based Vaccines for Allergen-Specific Immunotherapy: Potentials and Challenges of Conventional and Novel Adjuvants under Research

2020

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The increasing prevalence of allergic diseases demands efficient therapeutic strategies for their mitigation. Allergen-specific immunotherapy (AIT) is the only causal rather than symptomatic treatment method available for allergy. Currently, AIT is being administered using immune response modifiers or adjuvants. Adjuvants aid in the induction of a vigorous and long-lasting immune response, thereby improving the efficiency of AIT. The successful development of a novel adjuvant requires a thorough understanding of the conventional and novel adjuvants under development. Thus, this review discusses the potentials and challenges of these adjuvants and their mechanism of action. Vaccine development based on nanoparticles is a promising strategy for AIT, due to their inherent physicochemical properties, along with their ease of production and ability to stimulate innate immunity. Although nanoparticles have provided promising results as an adjuvant for AIT in in vivo studies, a deeper insight into the interaction of nanoparticle–allergen complexes with the immune system is necessary. This review focuses on the methods of harnessing the adjuvant effect of nanoparticles by detailing the molecular mechanisms underlying the immune response, which includes allergen uptake, processing, presentation, and induction of T cell differentiation.

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Metallic Nanoparticles: General Research Approaches to Immunological Characterization

Cited by 23 publications

References 136 publications

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives

Nanotechnology-Based Vaccines for Allergen-Specific Immunotherapy: Potentials and Challenges of Conventional and Novel Adjuvants under Research

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