Metallophytes for organic synthesis: towards new bio-based selective protection/deprotection procedures

Abstract

We propose for the first time using metal hyperaccumulating plants for the construction of a repertoire of protection and deprotection conditions in a concept of orthogonal sets. Protection of alcohol, carbonyl, carboxyl, and amino groups are considered. The ecocatalysts derived from metal-rich plants allow selective, mild, eco-friendly, and efficient protection or deprotection reactions. The selectivity is controlled by the choice of the metal, which is hyperaccumulated by the metallophyte.

From Conventional Lewis Acids to Heterogeneous Montmorillonite K10: Eco‐Friendly Plant‐Based Catalysts Used as Green Lewis Acids

“…The yellow solution is concentrated under vacuum then filtered through a pad of Celite if a purification step is necessary. The resulting solid residue, stored in a desiccator, may be used as an ecocatalyst or may be supported on silica or MK10 …”

“…Depending on the nature of the reaction, the crude catalysts were mixed (or not) with MK10 or SiO 2 as heterogeneous supports. Representative protection/deprotection reactions are summarized in Table …”

CC bond formation strategy through ecocatalysis: Insights from structural studies and synthetic potential

“…The first results have shown that ecocatalysts could present performances and selectivities which are significantly higher than those observed with classical homogeneous and heterogeneous catalysts [25][26][27]. They can be used as catalysts or reagents in the synthesis of molecules with high added value in fine and industrial chemistry (cosmetics, drugs and oligomers with biological interests, highly functionalized aromatic heterocycles, and biopesticides) [28][29][30]. As an example, we reported metallic species phytoextracted from Mn hyperaccumulators which allow the development of substitutive reagents to oxidants forbidden by REACH [31].…”

Benefits of Ryegrass on Multicontaminated Soils Part 2: A Green Process to Provide Idrocilamide

“…This corresponds to a mass of fresh shoot biomass of about 30 kg. In previous studies [58,59], heterogeneous catalysts from hyperaccumulators were used several times without any loss of catalytic activity. In the current study, Zn-BioCat was also reused 4 times, and it conserved its efficiency.…”