Metallopolysaccharide-Based Smart Nanotheranostic for Imaging-Guided Precise Phototherapy and Sequential Enzyme-Activated Ferroptosis

Zhu, Chengyuan; Wang, Yiliang; Li, Zhilang; Sun, Wanying; Jiang, Bang‐Ping; Shen, Xing‐Can

doi:10.1021/acs.biomac.2c00018

Cited by 13 publications

(7 citation statements)

References 62 publications

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“…In order to effectively convert light into a substantial amount of heat energy, it is vital to have strong NIR absorption. − The GSH-responsive enhancement of absorption at 808 nm makes the transformation of HA@V 2 O 5 NPs to HA@VO x NPs possible to be applied for GSH-activated PTT. To prove this expectation, the GSH-activated photothermal property of HA@V 2 O 5 NPs was primarily assessed.…”

Section: Resultsmentioning

confidence: 99%

Glutathione-Activated In Situ Transformation of Nanosized Vanadium Oxides for Postoperative Precision Tumor Theranostics

Chen

Wang

Qiu

et al. 2023

ACS Sustainable Chem. Eng.

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It is highly desirable to precisely observe the realtime location of residual tumor tissues after surgery without interference and further realize postoperative tumor-specific therapy. Herein, glutathione (GSH)-activated in situ transformation of nanosized vanadium (V) oxides (V 2 O 5 ) to mixed valence vanadium oxides (VO x ) was carried out to realize postoperative precision tumor theranostics. Especially, hyaluronic acid-hybridized V 2 O 5 nanoparticles (HA@V 2 O 5 NPs) were in-situtransformed to HA-hybridized VO x NPs via the reduction of GSH overexpressed in residual tumor. The transformation of V 2 O 5 to VO x could not only generate near-infrared absorption but also endow VO x with the ability to catalyze hydrogen peroxide to produce hydroxyl radicals. By combining receptor-mediated targeting (RMT) toward tumor cells of HA and GSH-activated in situ transformation, HA@V 2 O 5 NPs could be applied to precisely determine the location of residual tumor tissues in real time via photoacoustic (PA) observation without interference of inflammation after surgery and further realize postoperative tumor-specific photothermal/chemodynamic eradication of them. Therefore, the present work opens the way to utilize the combination strategy of RMT and GSH-activated in situ transformation of inorganic metal oxides to meet the need of postoperative precision tumor theranostics.

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Section: Resultsmentioning

confidence: 99%

Glutathione-Activated In Situ Transformation of Nanosized Vanadium Oxides for Postoperative Precision Tumor Theranostics

Chen

Wang

Qiu

et al. 2023

ACS Sustainable Chem. Eng.

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“…This imaging phenomenon is synergistic with anticancer therapy and allows different multiplexing techniques required for personalized therapy development. Zhu et al have developed a metallopolysaccharide‐based smart nanotheranostic system that explains the features and synergistic function of the imaging‐guided precise phototherapy and sequential enzyme‐activated ferroptosis (C. Zhu, Wang, et al, 2022).…”

Section: Nanomedicine‐based Anticancer Therapymentioning

confidence: 99%

Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐ and radioresistances

Kola

Nagesh

Roy

et al. 2023

WIREs Nanomed Nanobiotechnol

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The alarming increase in the number of breast cancer patients worldwide and the increasing death rate indicate that the traditional and current medicines are insufficient to fight against it. The onset of chemo-and radioresistances and cancer stem cell-based recurrence make this problem harder, and this hour needs a novel treatment approach. Competent nanoparticle-based accurate drug delivery and cancer nanotheranostics like photothermal therapy, photodynamic therapy, chemodynamic therapy, and sonodynamic therapy can be the key to solving this problem due to their unique characteristics. These innovative formulations can be a better cargo with fewer side effects than the standard chemotherapy and can eliminate the stability problems associated with cancer immunotherapy. The nanotheranostic systems can kill the tumor cells and the resistant breast cancer stem cells by novel mechanisms like local hyperthermia and reactive oxygen species and prevent tumor recurrence. These theranostic systems can also combine with chemotherapy or immunotherapy approaches. These combining approaches can be the future of anticancer therapy, especially to overcome the breast cancer stem cells mediated chemo-and radioresistances. This review paper discusses several novel theranostic systems and smart nanoparticles, their mechanism of action, and their modifications with time. It explains their relevance and market scope in the current era.

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“…Phototheranostic agents that are activated by laser irradiation have attracted considerable attention in the field of cancer diagnosis and treatment. − Under near-infrared (NIR) light irradiation, they can convert absorbed photons into local hyperthermia or generate reactive oxygen species (ROS) for photothermal therapy (PTT) and photodynamic therapy (PDT). − Through radiative and nonradiative processes, photon absorption can also achieve fluorescence and photoacoustic imaging. − Because of its passive and active targeting effects, phototheranostics allows for regionally focused tumor treatment. − However, due to limited tissue penetration and irregular tumor shapes, conventional phototheranostic agents frequently exhibit limited efficacy in the treatment of regionally focused tumors. − It is difficult to completely eliminate abnormally shaped malignant tumors using phototheranostics because some residual tumors remain, making the patient vulnerable to metastasis and recurrence. Therefore, practitioners urgently require the development of novel phototheranostics for precise and highly efficient phototherapy with post-treatment monitoring and imaging-guided programmed therapy for the elimination of residual tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Copper-Nitrogen-Coordinated Carbon Dots: Transformable Phototheranostics from Precise PTT/PDT to Post-Treatment Imaging-Guided PDT for Residual Tumor Cells

Zhang

Yang

Ruan

et al. 2023

ACS Appl. Mater. Interfaces

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Phototheranostics has attracted considerable attention in the fields of cancer diagnosis and treatment. However, the complete eradication of solid tumors using traditional phototheranostics is difficult because of the limited depth and range of laser irradiation. New phototheranostics enabling precise phototherapy and post-treatment imaging-guided programmed therapy for residual tumors is urgently required. Accordingly, this study developed a novel transformable phototheranostics by assembling hyaluronic acid (HA) with copper-nitrogen-coordinated carbon dots (CDs). In this transformable nanoplatform, named copper-nitrogen-CDs@HA, the HA component enables the specific targeting of cluster determinant (CD) 44-overexpressing tumor cells. In the tumor cells, redox glutathione converts Cu(II) (cupric ions) into Cu(I) (cuprous ions), which confers the novel transformable functionality to phototheranostics. Both in vitro and in vivo results reveal that the near-infrared-light-photoactivated CuII-N-CDs@HA could target CD44-overexpressing tumor cells for precise synergistic photothermal therapy and photodynamic therapy. This study is the first to observe that CuII-N-CDs@HA could escape from lysosomes and be transformed in situ into CuI-N-CDs@HA in tumor cells, with the d9 electronic configuration of Cu(II) changing to the d10 electronic configuration of Cu(I), which turns on their fluorescence and turns off their photothermal properties. This transformable phototheranostics could be used for post-treatment imaging-guided photodynamic therapy on residual tumor cells. Thus, the rationally designed copper-nitrogen-coordinated CDs offer a simple in situ transformation strategy for using multiple-stimulus-responsive precise phototheranostics in post-treatment monitoring of residual tumor cells and imaging-guided programmed therapy.

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Metallopolysaccharide-Based Smart Nanotheranostic for Imaging-Guided Precise Phototherapy and Sequential Enzyme-Activated Ferroptosis

Cited by 13 publications

References 62 publications

Glutathione-Activated In Situ Transformation of Nanosized Vanadium Oxides for Postoperative Precision Tumor Theranostics

Glutathione-Activated In Situ Transformation of Nanosized Vanadium Oxides for Postoperative Precision Tumor Theranostics

Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐ and radioresistances

Copper-Nitrogen-Coordinated Carbon Dots: Transformable Phototheranostics from Precise PTT/PDT to Post-Treatment Imaging-Guided PDT for Residual Tumor Cells

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