Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity

Lima, Maíra de Assis; Silva, Suély Vieira da; Serrano-Garrido, Orlando; Hülsemann, Maren; Santos-Neres, Luana; Rodrı́guez-Manzaneque, Juan Carlos; Hodgson, Louis; Freitas, Vanessa M.

doi:10.1016/j.cellsig.2020.109827

Cited by 13 publications

(9 citation statements)

References 46 publications

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“…ADAMTS15 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family and has been shown to function as a tumour suppressor by decreasing cell migration and invasion. 32 Similar to TP53, the tumour suppressor ADAMTS15 was also significantly upregulated in APA patients, which further confirmed the phenomenon that tumour suppressor genes were upregulated in APA. CCND1 is another hub mRNA identified in the MEG3 based ceRNA link.…”

Section: Discussionsupporting

confidence: 63%

Identification of potential lncRNA‐miRNA‐mRNA regulatory network contributing to aldosterone‐producing adenoma

Bao

2022

J Cellular Molecular Medi

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Primary aldosteronism (PA) is the most common cause of endocrine hypertension. 1 It is a heterogeneous group of disorders characterized by hypertension and aldosterone overproduction relatively autonomous from the renin-angiotensin system. The prevalence of PA is around 5% in patients with hypertension in primary care 2 and up to 20% in patients with resistant hypertension. 3 Compared with patients having primary hypertension harbouring matched CV risk profiles, patients with PA are likely to have increased risk of CV and cerebrovascular events, as well as the increased rate of metabolic syndrome. 4

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Section: Discussionsupporting

confidence: 63%

Identification of potential lncRNA‐miRNA‐mRNA regulatory network contributing to aldosterone‐producing adenoma

Bao

2022

J Cellular Molecular Medi

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“…ADAMTS12 acts as a cancer promoter in colorectal cancer via activating the Wnt/β-catenin signaling pathway in vitro [ 22 ]. On the contrary, ADAMTS1 is an additional tumor suppressed protein, which was markedly decreased in lung, ovarian, and breast cancer [ 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

The Novel Protein ADAMTS16 Promotes Gastric Carcinogenesis by Targeting IFI27 through the NF-κb Signaling Pathway

Zhou

Jiang

et al. 2022

IJMS

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A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAMTS16) has been reported to be involved in the pathogenesis of solid cancers. However, its role in gastric cancer (GC) is unclear. In this study, the role of ADAMTS16 in gastric cancer was investigated. The effects of ADAMTS16 on cell migration, invasion, and proliferation were investigated by functional experiments in vivo and in vitro. Downstream signal pathways of ADAMTS16 were confirmed by using bioinformatics analysis, co-immunoprecipitation, and immunofluorescence. Meanwhile, bioinformatics analysis, qRT-PCR, western blot, and dual-luciferase reporter gene analysis assays were used to identify ADAMTS16 targets. The expression of ADAMTS16 in GC was analyzed in public datasets. The expression of ADAMTS16 and its correlations with the clinical characteristics of GC were investigated by immunohistochemistry. Ectopic ADAMTS16 expression significantly promoted tumor cell migration, invasion, and growth. Bioinformatics analysis and western blot showed that ADAMTS16 upregulated the IFI27 protein through the NF-κb pathway, which was confirmed by immunofluorescence and western blot. Dual-luciferase reporter gene analysis identified a binding site between P65 and IFI27 that may be directly involved in the transcriptional regulation of IFI27. IFI27 knockdown reversed the promoting effect of ADAMTS16 on cell invasion, migration, and proliferation indicating that ADAMTS16 acts on GC cells by targeting the NF-κb/IFI27 axis. ADAMTS16 was associated with poor prognosis in clinical characteristics. ADAMTS16 promotes cell migration, invasion, and proliferation by targeting IFI27 through the NF-κB pathway and is a potential progressive and survival biomarker of GC.

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“…ADAMTS12 acts as a cancer promoter in colorectal cancer via activating the Wnt/β-catenin signaling pathway in vitro (21). On the contrary, ADAMTS1 is an additional tumor suppressed protein, which was markedly decreased in lung, ovarian and breast cancer (22)(23)(24).…”

Section: High Expression Adamts16 Is Associated With Poorer Clinical ...mentioning

confidence: 99%

The novel protein ADAMTS16 promotes gastric carcinogenesis by targeting IFI27 through the NF-κb signaling pathway

Zhou

Jiang

et al. 2022

Preprint

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Background A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAMTS16) has been reported to be involved in the pathogenesis of solid cancers. However, its role in gastric cancer (GC) is unclear. In this study, the role of ADAMTS16 in gastric cancer was investigated.Methods The effects of ADAMTS16 on cell migration, invasion and proliferation were investigated by functional experiments in vivo and vitro. Targets of ADAMTS16 were identified using bioinformatics analysis co-immunoprecipitation, immunofluorescence and dual-luciferase reporter gene analysis assays. The expression of ADAMTS16 in GC was analyzed in public datasets. The expression of ADAMTS16 and its correlations with the clinical characteristics of GC were investigated by immunohistochemistry.Results Ectopic ADAMTS16 expression significantly promoted tumor cell migration, invasion, and growth. Bioinformatics analysis and western blotting showed that ADAMTS16 upregulated the IFI27 protein through the NF-κb pathway, which was confirmed by immunofluorescence and western blot. Dual-luciferase reporter gene analysis identified a binding site between P65 and IFI27 that may be directly involved in the transcriptional regulation of IFI27. IFI27 knockdown reversed the promoting effect of ADAMTS16 on cell invasion,migration and proliferation indicating that ADAMTS16 acts on GC cells by targeting the NF-κb/IFI27 axis. ADAMTS16 was associated with poor prognosis in clinical characteristics.Conclusions ADAMTS16 promotes cell migration, invasion and proliferation by targeting IFI27 through the NF-κB pathway and is a potential progressive and survival biomarker of GC.

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Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity

Cited by 13 publications

References 46 publications

Identification of potential lncRNA‐miRNA‐mRNA regulatory network contributing to aldosterone‐producing adenoma

Identification of potential lncRNA‐miRNA‐mRNA regulatory network contributing to aldosterone‐producing adenoma

The Novel Protein ADAMTS16 Promotes Gastric Carcinogenesis by Targeting IFI27 through the NF-κb Signaling Pathway

The novel protein ADAMTS16 promotes gastric carcinogenesis by targeting IFI27 through the NF-κb signaling pathway

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