Metals and neurodegenerative diseases. A systematic review

Cicero, Calogero Edoardo; Mostile, Giovanni; Vasta, Rosario; Rapisarda, Venerando; Signorelli, Salvatore Santo; Ferrante, Margherita; Nicoletti, Alessandra

doi:10.1016/j.envres.2017.07.048

Cited by 209 publications

(132 citation statements)

References 172 publications

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“…The second model was additionally adjusted for BMI, smoking status, alcohol intake, residence area, vascular score, copper, lead, mercury and zinc. Lead and mercury are considered as suspected neurotoxicants [1]; serum copper and zinc concentrations might be considered as potential markers for AD [35]. PCBs, OC pesticides, total plasma lipids, education, BMI, vascular score, copper, lead, mercury and zinc were treated as continuous variables and introduced in the model on usual linear scale.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging

et al. 2019

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Background: Little attention has been paid to neurotoxicants on the risk of dementia. Exposure to known neurotoxicants such as polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is suspected to have adverse cognitive effects in older populations. Objective: To assess whether plasma concentrations of PCBs and OC pesticides are associated with the risk of cognitive decline, Alzheimer's disease (AD) and of all-cause dementia in the Canadian older population. Methods: Analyses were based on data from the Canadian Study of Health and Aging, a 3-phase, 10-year populationbased study of individuals aged 65+ years. Analyses included 669 clinically assessed subjects, of which 156 developed dementia including 108 incident cases of AD. Subjects were screened at each phase with the 100-point Modified Mini-Mental State Examination (3MS), a measurement of global cognitive function. Statistical analyses included Cox proportional hazards model when the outcome was dementia or AD, and a repeated-measure mixed model when the outcome was the 3MS score. (Continued on next page)

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Section: Discussionmentioning

confidence: 99%

“…Background There is increasing evidence suggesting the role of environmental factors in the development of dementia or Alzheimer's disease (AD) [1][2][3]. One systematic review including a meta-analysis reported a positive association between pesticide exposure and AD [4].…”

Section: Abstract: Alzheimer's Disease Dementia Cognitive Decline mentioning

confidence: 99%

Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging

et al. 2019

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“…With regard to the exposure to metals, systematic evidence includes mostly lead [22, 23, 40, 41], but also iron, selenium, manganese [22, 41], mercury [41] and aluminium [26]. Occupational exposure to lead has been found to be associated with the occurrence of ALS.…”

Section: Introductionmentioning

confidence: 99%

“…Cicero et al [41] performed a systematic review of observational case-control studies that assessed the association between metals and neurodegenerative diseases. In the case of ALS, they reviewed 20 studies dated between 1976 and 2017 and concluded that evidence was insufficient to support a causal relationship between exposure to metals and ALS [41]. …”

Section: Introductionmentioning

confidence: 99%

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

et al. 2018

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Background: It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent. Our objective here was to investigate the association between long-term exposure to environmental factors and the occurrence of ALS in Catalonia, Spain, and to provide evidence that spatial clusters of ALS related to these environmental factors exist. Methods: We carried out a nested case-control study constructed from a retrospective population-based cohort, covering the entire region. Environmental variables were the explanatory variables of interest. We controlled for both observed and unobserved confounders. Results: We have found some spatial clusters of ALS. The results from the multivariate model suggest that these clusters could be related to some of the environmental variables, in particular agricultural chemicals. In addition, in high-risk clusters, besides corresponding to agricultural areas, key road infrastructures with a high density of traffic are also located. Conclusion: Our results indicate that some environmental factors, in particular those associated with exposure to pesticides and air pollutants as a result of urban traffic, could be associated with the occurrence of ALS.

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“…Several genetic and environmental factors have been proposed to play a role in the ALS pathogenesis. Among environmental factors, metals seem to play a relevant role [7]. Volcanoes are a major source of metals [8] and Mount Etna is the largest active volcano in Europe.…”

mentioning

confidence: 99%

Amyotrophic lateral sclerosis spatial epidemiology in the Mount Etna region, Italy

Boumédiène

Vasta

Rascunà

et al. 2019

Euro J of Neurology

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Metals and neurodegenerative diseases. A systematic review

Cited by 209 publications

References 172 publications

Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging

Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

Amyotrophic lateral sclerosis spatial epidemiology in the Mount Etna region, Italy

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