In recent years, personalized fabrication has received considerable attention because of the widespread use of consumer‐level three‐dimensional (3D) printers. However, such 3D printers have drawbacks, such as long production time and limited output size, which hinder large‐scale rapid‐prototyping. In this paper, for the time‐ and cost‐effective fabrication of large‐scale objects, we propose a hybrid 3D fabrication method that combines 3D printing and the Zometool construction set, which is a compact, sturdy and reusable structure for infill fabrication. The proposed method significantly reduces fabrication cost and time by printing only thin 3D outer shells. In addition, we design an optimization framework to generate both a Zometol structure and printed surface partitions by optimizing several criteria, including printability, material cost and Zometool structure complexity. Moreover, we demonstrate the effectiveness of the proposed method by fabricating various large‐scale 3D models.