Metamorphosis of neutrophil transcriptional programme during <i>Leishmania</i> infection

DeSouza-Vieira, Thiago

doi:10.1111/pim.12922

Cited by 3 publications

(1 citation statement)

References 81 publications

(181 reference statements)

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“…In both acute and chronic inflammation, the genetic structures of neutrophils appear to undergo a reprogramming process due to the stimulation of external signals, resulting in dynamic transitions between subpopulations. 132 , 133 , 134 In inflammatory diseases, infection or ischemia can induce the production of G‐CSF, GM‐CSF, or other myelopoietic factors, which contribute to different functional neutrophils. 135 , 136 , 137 We will discuss what factors would contribute to neutrophil heterogeneity in the context of diseases.…”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.

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Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice

DeSouza-Vieira,

Pretti,

Lima Gomes

et al. 2024

PLoS Pathog

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Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release and phagocytosis. Enhanced neutrophil infiltration is associated with higher susceptibility to Leishmania infection, but neutrophil effector response contribution to this phenotype is uncertain. Here, we show that neutrophils from susceptible BALB/c mice (B/c) produce more NETs in response to Leishmania major than those from resistant C57BL/6 mice (B6), which are more phagocytic. The absence of neutrophil elastase contributes to phagocytosis regulation. Microarray analysis shows enrichment of genes involved in NET formation (mpo, pi3kcg, il1b) in B/c, while B6 shows upregulation of genes involved in phagocytosis and cell death (Arhgap12, casp9, mlkl, FasL). scRNA-seq in L. major-infected B6 showed heterogeneity in the pool of intralesional neutrophils, and we identified the N1 subset as the putative subpopulation involved with phagocytosis. In vivo, imaging validates NET formation in infected B/c ears where NETing neutrophils were mainly uninfected cells. NET digestion in vivo augmented parasite lymphatic drainage. Hence, a balance between NET formation and phagocytosis in neutrophils may contribute to the divergent phenotype observed in these mice.

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Host skin immunity to arthropod vector bites: from mice to humans

Lacsina,

Kissinger,

Doehl

et al. 2024

Front. Trop. Dis

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Infections caused by vector-borne pathogens impose a significant burden of morbidity and mortality in a global scale. In their quest for blood, hematophagous arthropods penetrate the host skin and may transmit pathogens by the bite. These pathogens are deposited along with saliva and a complex mixture of vector derived factors. Hematophagous arthopod vectors have evolved a complex array of adaptations to modulate the host immune response at the bite site with the primary goal to improve blood feeding, which have been exploited throughout evolution by these pathogens to enhance infection establishment in the host. While this paradigm has been firmly established in mouse models, comparable data from human studies are scarce. Here we review how the host skin immune response to vector bites in animal models is hijacked by microbes to promote their pathogenesis. We mainly explored four distinct vector-pathogen pairs of global health importance: sand flies and Leishmania parasites, Ixodes scapularis ticks and Borrelia burgdorferi, Aedes aegypti mosquitoes and arboviruses, and Anopheles gambiae mosquitos and Plasmodium parasites. Finally, we outline how critical it is for the field of vector biology to shift from rodent models to clinical studies focused on the interface of vector-pathogen-host immune system to push further the frontiers of knowledge of the field.

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Metamorphosis of neutrophil transcriptional programme during Leishmania infection

Cited by 3 publications

References 81 publications

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice

Host skin immunity to arthropod vector bites: from mice to humans

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