Metaplastic Breast Carcinoma with Unusual Presentation: Review of Three Cases

Perez, MI; Rodriguez, Isabel Viqueira; Royloa, Alberto Tello; Guisasola, J. Martínez

doi:10.1159/000441288

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Chondroid metaplasia is a relatively uncommon finding which has been described in different anatomical sites and conditions (both neoplastic and non-neoplastic), but is rarely reported in mesothelium 1 and even more occasionally in pleura. Chondroid metaplasia has been reported in tongue 2 , head and neck 3-5 , breast 6 7 , lung 8 and brain 9 . Formation of ectopic, metaplastic cartilage in the mesothelium is rare and only a few cases are reported in the literature 10-15 .…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Pleural chondroid metaplasia in a background of IgG4 plasma cell rich chronic inflammatory infiltrate: report of a rare case with review of literature

et al. 2019

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Summary Mesothelial reactive and degenerative changes secondary to inflammatory conditions, toxin exposure, neoplastic and non-neoplastic disease are often encountered in routine histopathology practice. Herein, we report a very rare case of pleural chronic inflammation with features suggestive for IgG4-related disease associated with the formation of a nest of mature, benign looking cartilage in the pleura of a middle age male patient. The review of the pertinent literature reveals that to date, only few cases of chondroid metaplasia or benign tumor (choristoma) are reported in mesothelium and only occasionally in this change is found in the pleura.

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Section: Discussion and Review Of Literaturementioning

confidence: 99%

Pleural chondroid metaplasia in a background of IgG4 plasma cell rich chronic inflammatory infiltrate: report of a rare case with review of literature

et al. 2019

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“…Lymph node status and lymphovascular invasion affects the outcome. Histological subtypes do not confer prognosis,13 and survival at 5 years is approximately 38%–65% 11 12…”

Section: Discussionmentioning

confidence: 99%

Rare case of metaplastic breast cancer in a man

et al. 2018

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Metaplastic breast cancer (MBC) in men is an extremely rare entity. MBC is typically very aggressive with a poor prognosis. In men, it has only been reported three times in the literature. We report a 47-year-old man who presented with right-sided breast erythema and nipple inversion. Mammogram revealed a 2.4 cm spiculated mass. Initial pathology was inconclusive; however, right-sided simple mastectomy showed invasive metaplastic carcinoma with adenosquamous histology. He received adjuvant chemotherapy with 4 cycles of dose dense Adriamycin and cyclophosphamide followed by 12 weeks of paclitaxel and chest wall radiation. Although oestrogen receptor status was 1%, tamoxifen was not given due to recent diagnosis of pulmonary embolism. Two years after treatment, he is currently living with no signs of recurrence. This case will serve as a useful addition to the current literature discussing successful diagnosis, treatment and prognosis of a man with MBC.

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“…Commonly MBC consists of epithelial (carcinomatous) and mesenchymal (sarcomatous) elements in a variable proportion [ 2 ]. MBC is regarded as ductal carcinoma that undergoes metaplasia into squamous cell, spindle cell and/or mesenchymal appearance [ 3 ]. Multiple immunohistochemical stainings are required for accurate diagnosis of these tumours because of their various histological patterns.…”

Section: Introductionmentioning

confidence: 99%

Human Metaplastic Breast Carcinoma and Decorin

Boström

Sainio

Eigėlienė

et al. 2017

Cancer Microenvironment

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Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM). However, little is known about the composition of the ECM and its constituents in MBC. Decorin is a ubiquitous ECM macromolecule known of its oncosuppressive activity. As such, it provides an intriguing molecule in the development of novel therapeutics for different malignancies such as MBC. In this study, decorin immunoreactivity and the effect of adenoviral decorin cDNA (Ad-DCN) transduction were examined in MBC. Multiple immunohistochemical stainings were used to characterize a massive breast tumour derived from an old woman. Furthermore, three-dimensional (3D) explant cultures derived from the tumour were transduced with Ad-DCN to study the effect of the transduction on the explants. The MBC tumour was shown to be completely negative for decorin immunoreactivity demonstrating that the malignant cells were not able to synthesize decorin. Ad-DCN transduction resulted in a markedly altered cytological phenotype of MBC explants by decreasing the amount of atypical cells and by inhibiting cell proliferation. The results of this study support approaches to develop new, decorin-based adjuvant therapies for MBC.Electronic supplementary materialThe online version of this article (doi:10.1007/s12307-017-0195-8) contains supplementary material, which is available to authorized users.

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Metaplastic Breast Carcinoma with Unusual Presentation: Review of Three Cases

Cited by 7 publications

References 17 publications

Pleural chondroid metaplasia in a background of IgG4 plasma cell rich chronic inflammatory infiltrate: report of a rare case with review of literature

Pleural chondroid metaplasia in a background of IgG4 plasma cell rich chronic inflammatory infiltrate: report of a rare case with review of literature

Rare case of metaplastic breast cancer in a man

Human Metaplastic Breast Carcinoma and Decorin

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