Metaplastic carcinomas of the breast. II. Spindle cell carcinoma

Wargotz, Eric S.; Deos, Phillip H.; Norris, Henry J.

doi:10.1016/0046-8177(89)90065-8

Cited by 306 publications

(292 citation statements)

References 17 publications

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“…33,36,37,[40][41][42][43][44] NGFR positivity was significantly higher in metaplastic breast carcinomas when compared to that of a population-based cohort of breast cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Representative sections of two adenomyoepitheliomas and 20 metaplastic breast carcinomas (reviewed by JSRF, FM and FCS and reclassified as seven spindle cell carcinomas, 33 two carcinomas with heterologous elements, 34 six carcinomas with squamous metaplasia 35 and five matrix-producing breast carcinomas 36 ) were analysed.…”

Section: Tumours With Myoepithelial Differentiationmentioning

confidence: 99%

“…In contrast, the epithelial cells of these two cases showed rather weak or focal expression. Metaplastic breast carcinomas, tumours known to harbour features of myoepithelial differentiation, 33 p75 expression in breast JS Reis-Filho et al not interpretable on the duplicate tissue cores. In all, 11 out of the remaining 223 cases (4.9%) showed NGFR immunoreactivity.…”

Section: Tumours With Myoepithelial Differentiationmentioning

confidence: 99%

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Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

et al. 2006

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Nerve growth factor receptor (NGFR) is a transmembrane glycoprotein without intrinsic tyrosine kinase activity, whose expression is not restricted to neural cells. NGFR is reported to act as a tumour suppressor, negatively regulating cell growth and proliferation. NGFR expression was immunohistochemically analysed in normal breast tissue and in 140 benign, biphasic and preinvasive breast lesions, in 22 tumours with myoepithelial differentiation and in two cohorts of breast cancer patients: a series of 245 invasive breast carcinomas studied with tissue microarrays and 37 high-grade invasive ductal carcinomas with basal-like immunophenotype. NGFR consistently displayed membrane reactivity in myoepithelial cells arranged as a continuous layer around normal ducts and lobular units, intralobular fibroblasts, vascular adventitia and nerve bundles. Myoepithelial cells of benign proliferations and pre-invasive lesions were consistently positive for NGFR. Scattered NGFRpositive cells were observed in solid areas of six out of nine cases of hyperplasia of usual type, whereas in flat atypia, lobular carcinoma in situ and virtually all cases of ductal carcinoma in situ (97.5%), NGFR was restricted to the myoepithelial layer. Positivity for NGFR was observed in 11 out of 245 (4.5%) breast carcinomas, nine out of 20 (45%) metaplastic breast carcinomas and 14 out of 37 (38%) basal-like breast carcinomas. NGFR expression in invasive tumours significantly correlated with that of cytokeratins 5/6 (Po0.05), 14 (Po0.0001) and 17 (Po0.0005) and EGFR (Po0.0001) and displayed an inverse correlation with oestrogen and progesterone receptors (both, Po0.0001). NGFR showed a statistically significant association with longer disease-free (Po0.05) and overall survival (Po0.01) in the cohort of patients with basal-like carcinomas. This study demonstrates the usefulness of NGFR as a new adjunct marker to identify myoepithelial cells in preinvasive lesions and myoepithelial differentiation in breast carcinomas. Furthermore, provisional data in a small number of basal-like breast carcinomas suggest that NGFR may identify a subgroup of basal-like breast carcinomas with good prognosis.

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“…33,36,37,[40][41][42][43][44] NGFR positivity was significantly higher in metaplastic breast carcinomas when compared to that of a population-based cohort of breast cancers.…”

Section: Discussionmentioning

confidence: 99%

Section: Tumours With Myoepithelial Differentiationmentioning

confidence: 99%

Section: Tumours With Myoepithelial Differentiationmentioning

confidence: 99%

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Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

et al. 2006

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“…Most reports divide metaplastic carcinomas into two broad categories: those that show squamous differentiation 4 and those that feature heterologous elements, such as, cartilage, bone, muscle, adipose tissue, vascular elements, and even melanocytes, among others 3,8 . Investigators at the Armed Forces Institute of Pathology categorize metaplastic carcinoma into five categories: squamous cell carcinomas 5 , spindle cell carcinomas 9 , carcinosarcoma 10 , matrix-producing carcinomas 4 , and carcinomas with osteoclastlike giant cells 11 . Squamous differentiation can range from well to poorly differentiated.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case on Metaplastic Squamous Cell Carcinoma of Breast

Jasani¹

2012

Int J of Biomed & Adv Res

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Metaplastic breast carcinomas represent a morphologically heterogeneous group of invasive breast cancers in which a variable portion of the glandular epithelial cells comprising the tumor have undergone transformation in an alternate cell type -either a nonglandular epithelial cell type or a mesenchymal cell type. Metaplastic carcinomas are uncommon lesions, representing less than < 5% of all invasive breast cancer. This is a case of 51 year old female with left breast swelling since 3 months. She underwent Modified Radical Mastectomy. The histopathological findings were in favour of diagnosis invasive metaplastic carcinoma of breast -squamous cell variant -well differentiated.

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“…What is emerging, however, is the view that many of these lesions show evidence of basal/ myoepithelial differentiation (Oberman, 1987;Wargotz et al, 1989;Foshini and Eusebi, 1998).…”

Section: Metaplastic Carcinomasmentioning

confidence: 99%

Aspects of molecular phenotype and its correlations with breast cancer behaviour and taxonomy

Hanby

2005

Br J Cancer

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The assessment of breast cancer morphology remains an important element in the evaluation of prognosis and therapeutic planning for this disease. The tumour morphology reflects the molecular profile that produced it and consequently each can be predictive of the other. The morphological attributes of a breast cancer, as assessed by histological examination, supply the breast cancer care team with invaluable prognostic and predictive information. Notwithstanding the great advances in molecular techniques available to study such tumours, morphology remains indispensable. Studies of most large cohorts of unselected breast cancers continue to show that grade, nodal status and tumour size remain the most powerful prognostic indicates in a multivariable analysis. It is these that are combined in the Nottingham Prognostic Index, the most widely used prognostic tool in use in the UK (Balslev et al, 1994). This is not to suggest that molecular events are not important, but morphology, the visual consequence of a chaotic interplay of multiple molecular alterations is readily analysed and interpreted. Interestingly, in order to comprehend the results of some cDNA array work, analysis has involved the elaboration of complex diagnostic representations of data -a neomorphological approach that surely reinvents the wheel.Tumour size and nodal status are very much temporal factors, whereas grade is very much a morphological attribute and is qualitative. In other words, grade is a reflection of the intrinsic qualities of a tumour and as a consequence, will give an indication of features such as to the rapidity of growth and probability of metastasis. In this review, I will concentrate on the relationship of the morphological attributes of breast cancer to underlying molecular events and give examples of how these relate both to long-established taxonomic categories, and to some emerging ones. I will also examine their relationship to predictive markers and to specific biological peculiarities. By molecular techniques, I will, elastically, also encompass some cytogenetic alterations.

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Metaplastic carcinomas of the breast. II. Spindle cell carcinoma

Cited by 306 publications

References 17 publications

Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

A Rare Case on Metaplastic Squamous Cell Carcinoma of Breast

Aspects of molecular phenotype and its correlations with breast cancer behaviour and taxonomy

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